Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights DOI Open Access
Deborah Agostini, Alessia Bartolacci,

Rossella Rotondo

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1325 - 1325

Published: April 11, 2025

Homocysteine, a sulfur-containing amino acid, is an intermediate product during the metabolism of methionine, vital acid. An elevated concentration homocysteine in plasma, named hyperhomocysteinemia, has been significantly related to onset several diseases, including diabetes, multiple sclerosis, osteoporosis, cancer, and neurodegenerative disorders such as dementia, Alzheimer’s Parkinson’s diseases. interaction between metabolic pathways gut microbiota reported, specific microbial signatures have found individuals experiencing hyperhomocysteinemia. Furthermore, some evidence suggests that modulation may exert influence on levels disease progression. Conventional approaches for managing hyperhomocysteinemia typically involve dietary interventions alongside administration supplements B vitamins betaine. The present review aims synthesize recent advancements understanding targeted at mitigating with particular emphasis role these strategies. emerging therapeutic potential reported Indeed, better complex species help finding novel strategies counteract

Language: Английский

Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights DOI Open Access
Deborah Agostini, Alessia Bartolacci,

Rossella Rotondo

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1325 - 1325

Published: April 11, 2025

Homocysteine, a sulfur-containing amino acid, is an intermediate product during the metabolism of methionine, vital acid. An elevated concentration homocysteine in plasma, named hyperhomocysteinemia, has been significantly related to onset several diseases, including diabetes, multiple sclerosis, osteoporosis, cancer, and neurodegenerative disorders such as dementia, Alzheimer’s Parkinson’s diseases. interaction between metabolic pathways gut microbiota reported, specific microbial signatures have found individuals experiencing hyperhomocysteinemia. Furthermore, some evidence suggests that modulation may exert influence on levels disease progression. Conventional approaches for managing hyperhomocysteinemia typically involve dietary interventions alongside administration supplements B vitamins betaine. The present review aims synthesize recent advancements understanding targeted at mitigating with particular emphasis role these strategies. emerging therapeutic potential reported Indeed, better complex species help finding novel strategies counteract

Language: Английский

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