In Silico Study on the Inhibition of Sitogluside from Clove Plant (Syzygium aromaticum) on Interleukin 2 in B and T Cell Proliferation DOI Open Access
Linda Rosalina, Devi Purnamasari,

Rismi Verawati

et al.

Pharmacognosy Journal, Journal Year: 2023, Volume and Issue: 15(4), P. 575 - 580

Published: Aug. 15, 2023

This research discusses an in-silico study of sitogluside found in the clove plant (Syzygium aromaticum) as a potential inhibitor B and T cell proliferation through interaction with Interleukin-2. utilizes methods such Swiss Target Prediction, Pymol, Pyrex, Protein Plus, Lipinski's Rule to predict biological activity pharmacokinetic characteristics sitogluside. From docking simulation results, exhibited strong interactions interleukin-2 RMSD values 0, 1.637, 2.299, Binding Affinities -5.7, -5.5, indicating its effectiveness inhibitor. In addition, fulfills rule molecular mass 520, 4 hydrogen bond donors acceptors, log P value 2.3, molar reactivity 133, high for good bioavailability systems. These results suggest that from holds new therapy inhibiting proliferation, however further is needed validate these findings explore clinical treatments.

Language: Английский

In Silico Study on the Inhibition of Sitogluside from Clove Plant (Syzygium aromaticum) on Interleukin 2 in B and T Cell Proliferation DOI Open Access
Linda Rosalina, Devi Purnamasari,

Rismi Verawati

et al.

Pharmacognosy Journal, Journal Year: 2023, Volume and Issue: 15(4), P. 575 - 580

Published: Aug. 15, 2023

This research discusses an in-silico study of sitogluside found in the clove plant (Syzygium aromaticum) as a potential inhibitor B and T cell proliferation through interaction with Interleukin-2. utilizes methods such Swiss Target Prediction, Pymol, Pyrex, Protein Plus, Lipinski's Rule to predict biological activity pharmacokinetic characteristics sitogluside. From docking simulation results, exhibited strong interactions interleukin-2 RMSD values 0, 1.637, 2.299, Binding Affinities -5.7, -5.5, indicating its effectiveness inhibitor. In addition, fulfills rule molecular mass 520, 4 hydrogen bond donors acceptors, log P value 2.3, molar reactivity 133, high for good bioavailability systems. These results suggest that from holds new therapy inhibiting proliferation, however further is needed validate these findings explore clinical treatments.

Language: Английский

Citations

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