The impact of heavy metals exposure on male fertility: a scoping review of human studies

Journal of Basic and Clinical Physiology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Introduction Male infertility is a critical global health issue, with environmental and occupational exposure to heavy metals, such as lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), impacting male reproductive health. This scoping review aims evaluate the effects of metal on semen parameters. Content study adhered 2020 PRISMA framework. A broad literature search was performed January 2025, using Embase, PUBMED, Scopus. comprehensive PubMed, Scopus 12, combination Medical Subject terms keywords. Summary Of 1,709 identified studies, 21 met inclusion criteria were analyzed. Findings indicate that negatively impacts sperm concentration, motility, morphology, primarily through oxidative stress enzymatic inhibition. Cadmium disrupts blood-testis barrier acrosomal function, leading abnormalities. Arsenic linked stress, apoptosis, impaired motility. Outlook The cumulative evidence supports strong association between infertility. underscores need for stricter safety regulations policies mitigate exposure.

Language: Английский

Does the Quality and Readability of Information Related to Varicocele Obtained from ChatGPT 4.0 Remain Consistent Across Different Models of Inquiry?

The World Journal of Men s Health, Journal Year: 2025, Volume and Issue: 43

Published: Jan. 1, 2025

Language: Английский

Global Andrology Forum (GAF) Clinical Guidelines on the Management of Non-obstructive Azoospermia: Bridging the Gap between Controversy and Consensus

The World Journal of Men s Health, Journal Year: 2025, Volume and Issue: 43

Published: Jan. 1, 2025

Language: Английский