Quantitative Analysis of Drug from Bulk as Well as Formulation DOI Open Access
Omkar S. Deshmukh,

Sonali Mehendre,

Smita Nayak

et al.

International Journal for Research in Applied Science and Engineering Technology, Journal Year: 2023, Volume and Issue: 11(8), P. 1057 - 1069

Published: Aug. 13, 2023

Abstract: A simple, precise, accurate method was developed for the estimation of molnupiravir by RP HPLC. Chromatographic conditions used are stationary phase Hemochrom C18 (4.6mm x 250mm 5μm), mobile methanol 5 minutes then 0.1% orthophosphoric acid and in a ratio 50:50 from – 20 min. The flow rate maintained at 1.0 ml/min, detection wavelength 235 nm, column temperature set to 30. C diluent were water (50:50) finalized as an optimized method. System suitability parameters studied injecting standard six times results well under acceptance limits. Theretention time 10 validated linearity, accuracy, precision, specificity, limit quantification, detection, robustness. quantificationwas found be 0.5 μg/ml 1.5 respectively recovery capsule 98.72 %. proposed successfully applied quantitative determination formulation.

Language: Английский

Quantitative Analysis of Drug from Bulk as Well as Formulation DOI Open Access
Omkar S. Deshmukh,

Sonali Mehendre,

Smita Nayak

et al.

International Journal for Research in Applied Science and Engineering Technology, Journal Year: 2023, Volume and Issue: 11(8), P. 1057 - 1069

Published: Aug. 13, 2023

Abstract: A simple, precise, accurate method was developed for the estimation of molnupiravir by RP HPLC. Chromatographic conditions used are stationary phase Hemochrom C18 (4.6mm x 250mm 5μm), mobile methanol 5 minutes then 0.1% orthophosphoric acid and in a ratio 50:50 from – 20 min. The flow rate maintained at 1.0 ml/min, detection wavelength 235 nm, column temperature set to 30. C diluent were water (50:50) finalized as an optimized method. System suitability parameters studied injecting standard six times results well under acceptance limits. Theretention time 10 validated linearity, accuracy, precision, specificity, limit quantification, detection, robustness. quantificationwas found be 0.5 μg/ml 1.5 respectively recovery capsule 98.72 %. proposed successfully applied quantitative determination formulation.

Language: Английский

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