Key spirometric parameters for post-tuberculosis sequelae in patients after new coronavirus infection DOI
Goar S. Balasaniants,

S. Abdrakhmanova,

Л. Т. Гильмутдинова

et al.

Bulletin of the Russian Military Medical Academy, Journal Year: 2024, Volume and Issue: 26(4), P. 597 - 606

Published: Dec. 16, 2024

The study evaluated key spirometric parameters in patients with post-tuberculosis (post-TB) lung sequelae after recovery from a new coronavirus infection. main group incliuded 14 clinically cured respiratory tuberculosis who had recovered the infection and, recovery, were sent to Glukhovskaya sanatorium for treatment 2020-2021. control included 52 residual post-TB sequelae, did not have and treated at during same period. groups comparable terms of epidemiological clinical criteria, except sequelae: 13 cases (92.9%) minor 1 case (7.1%) major 36 (69.2%) 16 (30.8%) cases, respectively. Pulmonary function tests vital capacity, forced expiratory volume second, second/forced capacity. Tests performed admission month. At stage group, capacity second on average below predicted level (80%) compared improved slightly. In initial indicators significantly higher, rates lungs 2nd examination, levels approached, 1st they reached norm. baseline, low ventilatory correlated symptoms, as 42.8% 55.7% controls reported shortness breath. However, treatment, more often showed 60%: 7.7% 17.3% 11.5% while mostly slight or moderate decrease these parameters. Therefore, has negative impact functional system, but also contribute development disorders.

Language: Английский

Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the 2nd International Post-Tuberculosis Symposium DOI
Sara C. Auld, Amy K. Barczak, William R. Bishai

et al.

American Journal of Respiratory and Critical Care Medicine, Journal Year: 2024, Volume and Issue: 210(8), P. 979 - 993

Published: Aug. 14, 2024

Post-tuberculosis (post-TB) lung disease is increasingly recognized as a major contributor to the global burden of chronic disease, with recent estimates indicating that over half TB survivors have impaired function after successful completion treatment. However, pathologic mechanisms contribute post-TB are not well understood, thus limiting development therapeutic interventions improve long-term outcomes TB. This report summarizes work Pathogenesis and Risk Factors Committee for Second International Post-Tuberculosis Symposium, which took place in Stellenbosch, South Africa, April 2023. The committee first identified six areas high translational potential: 1) tissue matrix destruction, including role metalloproteinase dysregulation neutrophil activity; 2) fibroblasts profibrotic 3) granuloma fate cell death pathways; 4) mycobacterial factors, pathogen burden; 5) animal models; 6) impact key clinical risk HIV, diabetes, smoking, malnutrition, alcohol. We share findings from literature review those areas, highlighting knowledge gaps where further research needed.

Language: Английский

Citations

4
A year in review – evaluating the launch of IJTLD OPEN DOI Creative Commons

H. D. Blackbourn,

Giovanni Battista Migliori

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 1 - 2

Published: Jan. 1, 2025

One year on from the launch of our new open access (OA) journal, IJTLD OPEN, we review its impact. Similar to flagship IJTLD, articles published in OPEN span a range topics related lung health and majority focus TB low- middle-income countries (LMICs). Interestingly, there has been no lag period readers accessing content, with downloads for soon matching exceeding those IJTLD. This demonstrates that OA is helping us achieve goal improving knowledge dissemination LMICs, where restricted subscription journals. Citation analysis first few issues also suggests this higher level leading being cited at an accelerated rate.

Language: Английский

Citations

0
The prevalence and pattern of post tuberculosis lung disease including pulmonary hypertension from an Australian TB service; a single-centre, retrospective cohort study DOI Creative Commons
Anthony Byrne,

Yasmeen Al‐Hindawi,

M. Plit

et al.

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

Language: Английский

Citations

0
A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2025 Update for Clinicians and Scientists DOI Creative Commons

Christoph Lange,

Graham Bothamley, Gunar Günther

et al.

Pathogens and Immunity, Journal Year: 2025, Volume and Issue: 10(2), P. 1 - 45

Published: March 2, 2025

In the field of tuberculosis and non-tuberculous mycobacterial (NTM) disease we are looking back on an exciting year 2024 with more than 10,000 publications listed in PubMed. Our aim, to review scientific literature 2024, is challenged by enormous number publications. Therefore, if your article not included or favorite mycobacteriology covered, please forgive us. "Year Review" very much clinically oriented lesser emphasis basic science, microbiology, biotechnology. Members steering committee Tuberculosis Network European Trials group (TBnet; www.tbnet.eu) report 139 fields epidemiology, prevention, diagnosis, treatment NTM diseases published that found particularly important. We separately for children adults provide a brief overview newer technologies diagnostic pipeline. Furthermore, summarize priorities research, development, implementation, all which represent perspective our combined clinical experience. This Year Review provides concise summary relevant highlights 2024.

Language: Английский

Citations

0
The role of neutrophil response in lung damage and post-tuberculosis lung disease: a translational narrative review DOI Creative Commons
Ana Paula Santos, Luciana Silva Rodrigues, Nils Rother

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 7, 2025

It is estimated that more than 150 million individuals alive in 2020 had survived tuberculosis (TB). A portion of this large population continues to experience chronic respiratory abnormalities, with or without symptoms, due previous active pulmonary TB. This condition known as Post-TB Lung Disease (PTLD), involves a complex interaction between pathogen, host and environmental factors. These interactions are believed drive hyperinflammatory process the lungs during TB, resulting tissue damage, which may lead radiological sequelae, impaired function, clinical such cough, dyspnea, hemoptysis, infections. Such complications impose significant health, financial, social burdens, remain poorly understood inadequately addressed by health care systems. Given heterogeneity immune cells their products infiltrating airways lung parenchyma acute inflammation caused Mycobacterium infection, it evident TB immunopathology multifactorial. Among various components involved, neutrophils have recently emerged critical contributors deleterious response against leading severe damage. In translational narrative review, we aim summarize role primary - proteases (such elastase), matrix metalloproteinases extracellular traps (NETs) We highlight new concepts emerging evidence neutrophil involvement disease, translating these insights from "bench bedside" facilitate dialogue fundamental researchers practitioners. Additionally, present potential targets for future treatment strategies could mitigate even prevent PTLD.

Language: Английский

Citations

0
Post-tuberculosis lung disease: towards prevention, diagnosis, and care DOI
Jamilah Meghji, Sara C. Auld,

Gregory P. Bisson

et al.

The Lancet Respiratory Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Beyond a cure for TB: confronting the hidden burden of post-TB lung disease DOI Creative Commons
Yousra Kherabi,

D. R. Silva,

Rosella Centis

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(5), P. 248 - 250

Published: May 9, 2025

Although much attention is given to diagnosis and treatment for TB, recent evidence highlights the suffering that occurs after patients are ‘cured’. This issue of IJTLD Open includes two studies improve our understanding long-term impact TB. First, a study in Kenya, Uganda, Zambia Zimbabwe evaluated feasibility assessing referring TB comorbidities, risk factors disabilities within national programmes. Second, who successfully completed China sheds light on sequelae The combined findings reinforce need integrate care strategies into programmes address these health challenges.

Language: Английский

Citations

0
Guidelines for the diagnosis and management of post-TB lung disease: a call to action DOI Creative Commons
Denise Rossato Silva, Sandra Inwentarz

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(3), P. 101 - 102

Published: March 1, 2024

Language: Английский

Citations

2
An item bank to measure health-related quality of life among young children (0-5-years-old) affected by respiratory illnesses – expert stakeholders and end-users from the Western Cape, South Africa DOI Creative Commons
Michaile G. Anthony,

Margaret van Niekerk,

Anneke C. Hesseling

et al.

Health and Quality of Life Outcomes, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 29, 2024

Abstract Background Health-related quality of life (HRQoL) is a crucial patient-centred outcome for developing policy. However, there lack appropriate HRQoL measures young children (0-5-years), who are particularly vulnerable to respiratory illnesses like pulmonary tuberculosis (PTB) and other infections, especially in low- middle-income countries (LMICs). We aimed develop disease-specific item bank with acute chronic illnesses. Methods An exploratory sequential design three phases was used bank. The content validity the evaluated by local international experts specialising child health. group included paediatric pulmonologists, researchers expertise illnesses, scale development. Cognitive interviews 37 caregivers TB, pneumonia, adenovirus infection, lower tract reactive airway disease, protracted bronchitis Cape Town, South Africa, consultations 22 stakeholders were conducted final revisions. progressively refined at each phase study. Findings Delphi recommended dividing into two age groups (0-2-years 3-5-years) using 5-point Likert scale. Overall, 41 items (42%) met predetermined > 70% threshold inclusion confirmed that domains relevant. Minor modifications made five cohort 1 (0-2-years) seven 2 (3-5-years), 8 (13%) 14 (22%) excluded. Phase 3 emphasised importance including all expanding cover early childhood development, play, social interactions, care routines. includes versions both incorporates these refinements. Conclusion developed as first step comprehensive tool an LMIC. Input from creating banks tailored developmental differences between 0 3-5-year groups. Their contributions ensured effectively captures age-appropriate aspects HRQoL. Future studies should focus on assessing reliability banks.

Language: Английский

Citations

1
TB survivors: why curing TB is sometimes not enough DOI
Emanuele Pontali, Rosella Centis

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(12), P. 531 - 532

Published: Dec. 1, 2024

It is now well understood that the effect of TB does not always end when a patient completes successful course treatment. Successful treatment by definition microbiological cure, but people may continue to suffer consequences for months or years after For example, ongoing health challenges can present in form post-TB lung disease (PTLD), and there high incidence TB-related symptoms associated with disability other domains. We discuss an article this issue

Language: Английский

Citations

1