Lifestyle, Cognition, and Disability Outcomes in Multiple Sclerosis: A Comprehensive Cohort Study DOI Open Access
Kenia Repiso Campanholo,

Graziella Aguiar santos Faria,

Milena Sales Pitombeira

et al.

Sclerosis, Journal Year: 2024, Volume and Issue: 2(4), P. 394 - 404

Published: Dec. 18, 2024

Background/Objectives: People with multiple sclerosis (MS) often experience sensory, psychomotor, and cognitive impairment, sphincter disturbances, fatigue, which can affect their ability to perform work-related tasks, self-care, daily activities. This study aimed analyze the lifestyle changes, function, disability outcomes over a seven-year follow-up period, exploring potential associations predictive markers. Methods: At end of 32 participants returned for clinical reassessment Twenty-Five-Foot Walk Test, Nine-Hole Peg Brief Repeatable Neuropsychological Battery. Lifestyle data were acquired via interviews regarding sleep quality, reading habits, technology use, physical activity levels, household responsibilities, participation in leisure cultural Results: The occupational profile did not demonstrate significant but 11 (34%) showed accumulation, number relapses increased (p = 0.001). Over time, improvement was observed verbal episodic memory worsening psychomotor speed. Better performance mental agility associated higher levels 0.021) use 0.039). In addition, better cognition (verbal p 0.038 processing speed 0.015) (upper limbs 0.017 lower 0.003) functional 0.022) maintenance Conclusions: changes more prominent memory, speed, good mainly treatment strategies should include pharmacological interventions.

Language: Английский

Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 871 - 899

Published: May 18, 2024

Language: Английский

Citations

4
Cognitive disorders in patients with neuroimmunological disease DOI
Miguel Restrepo-Martínez, Vaughan Bell, Jesús Ramírez‐Bermúdez

et al.

Current Opinion in Psychiatry, Journal Year: 2025, Volume and Issue: 38(2), P. 126 - 133

Published: Jan. 24, 2025

Purpose of review Autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS), and autoimmune encephalitis can directly indirectly affect brain function, leading to cognitive dysfunction or well characterized neurocognitive syndromes. However, these are often poorly in the literature. Here, we evidence on clinical manifestations, risk factors, their assessment outcomes, for underlying mechanisms associated biomarkers, if available. Recent findings Significant advances have been made disorders with four categories disease: due connective tissue diseases, demyelinating CNS, encephalitis, cerebrovascular disease origin. Summary should be considered critical causal factors new cases disorder, especially young patients. These mediated by immune system reactions involving antibody production, T-cell-mediated damage, demyelination. Although prognosis seems favourable most conditions after immunotherapy, magnitude therapeutic effect immunotherapy functioning remains unclear.

Language: Английский

Citations

0
Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy DOI Creative Commons

Jiajia Wang,

Xiaona Xia, Bin Zhang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 18, 2024

Objectives To explore the relationship between glymphatic dysfunction and cognitive impairment in unilateral temporal lobe epilepsy (TLE). Methods This study retrospectively included 38 patients with TLE 26 age- gender-matched healthy controls (HCs). The diffusion tensor image analysis along perivascular space (DTI-ALPS) index, choroid plexus volume (CPV), assessment were obtained for each participant. Neuropsychological test batteries Montreal Cognitive Assessment (MoCA), Minimum Mental State Examination, Arithmetic Test (AT), Digit Symbol Substitution (DSST), Span (DST), Boston Naming Test, Block design, Phonological Fluency (PFT), Semantic Verbal (SVF). Results Compared to HCs, had lower scores of MoCA, AT, DSST, DST, PFT SVF (all p < 0.05) values mean DTI-ALPS index (1.491 ± 0.142 vs. 1.642 0.123, 0.001). Significantly observed ipsilateral hemisphere than contralateral (1.466 0.129 1.517 0.175, = 0.013) TLE. Correlation analyses found that performance was significantly or borderline associated function ( FDR-corrected 0.05 all 0.057 CPV) patients. Linear regression showed increased CPV decreased independent risk factors semantic fluency 0.05). Furthermore, mediation mediator role enlargement (indirect effect: β −0.182, 95%CI −0.486 −0.037). Conclusion These findings reveal important Decreased are impairment. may fully mediate CP performance. insights provide a radiological foundation further investigations into mechanism system pathophysiology.

Language: Английский

Citations

1
White matter lesion load and location in relation to cognitive impairment in relapsing–remitting multiple sclerosis DOI Creative Commons
M. Ezzeldin, Eman M. Khedr, Ahmed Nasreldein

et al.

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Journal Year: 2024, Volume and Issue: 60(1)

Published: April 15, 2024

Abstract Background In relapsing–remitting multiple sclerosis (RRMS) the connection between cognitive impairment (CI) and white matter lesion load (WM-LL) location is still unclear. This study aimed to identify relationship CI in RRMS patients WM-LL locations using a fully automated platform. were evaluated 90 with Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) Automated MRI volumetric measures of distribution. Regression analysis BICAMS as dependent variable different clinical radiological parameters was performed. Results Data obtained from who had mean age 32.74 ± 8.43 years female-to-male ratio 3:1. The (± SD) rating scores subtests 28.07 11.78 Symbol Digit Modalities Test (SDMT), 42.32 12.46 California Verbal Learning Test-II (CVLT-II), 16.13 8.17 Visuospatial Memory Test-Revised (BVMT-R). According criteria, 29 cases (32.2%) CI. significantly correlated age, education level, relapse frequency, disease duration, time start disease-modifying therapies. Whole periventricular associated After controlling sex, education, logistic regression revealed that total best predictor together duration illness education. cut-off value 12.85 cc predicted Conclusions are anatomical predictors probably due effect on anterior commissural fibers while demographic

Language: Английский

Citations

0
Clinical, immunological and neuroimaging spectrum of CNS lupus: can we reliably differentiate it from MS? DOI Creative Commons
Anna Wójcicka-Frankiewicz, Mikołaj A. Pawlak, Alicja Kalinowska-Łyszczarz

et al.

Neurologia i Neurochirurgia Polska, Journal Year: 2024, Volume and Issue: 58(6), P. 557 - 568

Published: Dec. 27, 2024

Language: Английский

Citations

0
Facts and myths about aggressive relapsing-remitting multiple sclerosis — current state of knowledge and future perspectives DOI Creative Commons
Klara Dyczkowska, Alicja Kalinowska-Łyszczarz

Neurologia i Neurochirurgia Polska, Journal Year: 2024, Volume and Issue: 58(6), P. 548 - 556

Published: Dec. 27, 2024

Language: Английский

Citations

0
Lifestyle, Cognition, and Disability Outcomes in Multiple Sclerosis: A Comprehensive Cohort Study DOI Open Access
Kenia Repiso Campanholo,

Graziella Aguiar santos Faria,

Milena Sales Pitombeira

et al.

Sclerosis, Journal Year: 2024, Volume and Issue: 2(4), P. 394 - 404

Published: Dec. 18, 2024

Background/Objectives: People with multiple sclerosis (MS) often experience sensory, psychomotor, and cognitive impairment, sphincter disturbances, fatigue, which can affect their ability to perform work-related tasks, self-care, daily activities. This study aimed analyze the lifestyle changes, function, disability outcomes over a seven-year follow-up period, exploring potential associations predictive markers. Methods: At end of 32 participants returned for clinical reassessment Twenty-Five-Foot Walk Test, Nine-Hole Peg Brief Repeatable Neuropsychological Battery. Lifestyle data were acquired via interviews regarding sleep quality, reading habits, technology use, physical activity levels, household responsibilities, participation in leisure cultural Results: The occupational profile did not demonstrate significant but 11 (34%) showed accumulation, number relapses increased (p = 0.001). Over time, improvement was observed verbal episodic memory worsening psychomotor speed. Better performance mental agility associated higher levels 0.021) use 0.039). In addition, better cognition (verbal p 0.038 processing speed 0.015) (upper limbs 0.017 lower 0.003) functional 0.022) maintenance Conclusions: changes more prominent memory, speed, good mainly treatment strategies should include pharmacological interventions.

Language: Английский

Citations

0