Nasal Rinsing with Probiotics—Microbiome Evaluation in Patients with Inflammatory Diseases of the Nasal Mucosa DOI Open Access
Eliza Brożek-Mądry,

Laura Ziuzia-Januszewska,

Oliwier Misztal

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(10), P. 3341 - 3341

Published: May 11, 2025

Background/Objectives: The evidence regarding the efficacy of probiotics in chronic rhinosinusitis (CRS) is very limited, prompting EPOS2020 steering group to advise against their use CRS treatment. Therefore, further research evaluate impact on microbial communities particularly important. This study aimed assess influence probiotic nasal rinses microbiota profiles patients with primary CRS, granulomatosis polyangiitis (GPA), and septal perforation (NSP) using 16S rRNA sequencing. Methods: Thirty-six mucosal diseases, including sixteen eleven GPA, nine NSP, were randomly assigned either a receiving containing Lactobacillus plantarum Bifidobacterium animalis, or control saline. Metagenomic analysis targeting V3–V4 hypervariable region gene was performed characterize bacterial archaeal populations. Results: At genus level, most abundant co-colonizers included Staphylococcus, Streptococcus, Haemophilus. After one month rinsing, decrease abundance genera Finegoldia (p = 0.010), Haemophilus 0.020), Streptococcus 0.027), Staphylococcus 0.033), Micrococcus 0.035), Corynebacterium 0.049), Gemella 0.055), Rubrobacter Pseudonocardia 0.058) observed. Conversely, species animalis increased. Moreover, increases Dolosigranulum Stenotrophomonas observed, although they did not reach statistical significance. Conclusions: Probiotic may contribute restoring homeostasis by reducing associated inflammatory dysbiosis warranting clinical benefits.

Language: Английский

Nasal Rinsing with Probiotics—Microbiome Evaluation in Patients with Inflammatory Diseases of the Nasal Mucosa DOI Open Access
Eliza Brożek-Mądry,

Laura Ziuzia-Januszewska,

Oliwier Misztal

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(10), P. 3341 - 3341

Published: May 11, 2025

Background/Objectives: The evidence regarding the efficacy of probiotics in chronic rhinosinusitis (CRS) is very limited, prompting EPOS2020 steering group to advise against their use CRS treatment. Therefore, further research evaluate impact on microbial communities particularly important. This study aimed assess influence probiotic nasal rinses microbiota profiles patients with primary CRS, granulomatosis polyangiitis (GPA), and septal perforation (NSP) using 16S rRNA sequencing. Methods: Thirty-six mucosal diseases, including sixteen eleven GPA, nine NSP, were randomly assigned either a receiving containing Lactobacillus plantarum Bifidobacterium animalis, or control saline. Metagenomic analysis targeting V3–V4 hypervariable region gene was performed characterize bacterial archaeal populations. Results: At genus level, most abundant co-colonizers included Staphylococcus, Streptococcus, Haemophilus. After one month rinsing, decrease abundance genera Finegoldia (p = 0.010), Haemophilus 0.020), Streptococcus 0.027), Staphylococcus 0.033), Micrococcus 0.035), Corynebacterium 0.049), Gemella 0.055), Rubrobacter Pseudonocardia 0.058) observed. Conversely, species animalis increased. Moreover, increases Dolosigranulum Stenotrophomonas observed, although they did not reach statistical significance. Conclusions: Probiotic may contribute restoring homeostasis by reducing associated inflammatory dysbiosis warranting clinical benefits.

Language: Английский

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