Harnessing the Power of Vitexin as a Vitamin D Receptor Agonist in Colorectal Cancer: A New Frontier DOI Creative Commons
Manahil Mubeen,

Hafsa Ali,

Sitwat Zehra

et al.

Balkan Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Colorectal cancer (CRC) presents an enormous burden on cancerrelated deaths and ranks third in cancer-associated mortality both men women worldwide. 1CRC develops when stem cells at the base of colon's crypts experience genetic epigenetic alterations.Normal become cancerous because these changes, which disrupts delicate balance between oncogenes tumor suppressor genes. 1 Surgery, chemotherapy, radiation, immunotherapy, targeted therapy are routine therapies for CRC.Nonetheless, depending CRC subtype, prognosis following chemotherapy varies considerably. 2More than 20% incidences linked to long-term inflammation often observed patients with inflammatory bowel disease (IBD).This type CRC, called colitis-associated colorectal (CAC), is common IBD.

Language: Английский

Harnessing the Power of Vitexin as a Vitamin D Receptor Agonist in Colorectal Cancer: A New Frontier DOI Creative Commons
Manahil Mubeen,

Hafsa Ali,

Sitwat Zehra

et al.

Balkan Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Colorectal cancer (CRC) presents an enormous burden on cancerrelated deaths and ranks third in cancer-associated mortality both men women worldwide. 1CRC develops when stem cells at the base of colon's crypts experience genetic epigenetic alterations.Normal become cancerous because these changes, which disrupts delicate balance between oncogenes tumor suppressor genes. 1 Surgery, chemotherapy, radiation, immunotherapy, targeted therapy are routine therapies for CRC.Nonetheless, depending CRC subtype, prognosis following chemotherapy varies considerably. 2More than 20% incidences linked to long-term inflammation often observed patients with inflammatory bowel disease (IBD).This type CRC, called colitis-associated colorectal (CAC), is common IBD.

Language: Английский

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