Natural Products from Cyanobacteria: Focus on Beneficial Activities

Marine Drugs, Journal Year: 2019, Volume and Issue: 17(6), P. 320 - 320

Published: May 30, 2019

Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities the diversity of natural products they synthesize, support cyanobacterial success in colonization their respective ecological niches. Although cyanobacteria well-known for toxin production relative deleterious consequences, also produce a large variety molecules exhibit beneficial properties with high potential various fields (e.g., synthetic analog dolastatin 10 is used against Hodgkin's lymphoma). The present review focuses on activities described so far. Based an analysis 670 papers, it appears more than 90 genera have been observed compounds potentially which most them belong orders Oscillatoriales, Nostocales, Chroococcales, Synechococcales. rest (i.e., Pleurocapsales, Chroococcidiopsales, Gloeobacterales) remain poorly explored terms molecular bioactivity. metabolites possessing bioactivities different chemical classes (alkaloids, depsipeptides, lipopeptides, macrolides/lactones, peptides, terpenes, polysaccharides, lipids, polyketides, others) 14 major kinds However, no direct relationship between class bioactivity these has demonstrated. We further selected specifically 47 molecule families according uses pharmacology, cosmetology, agriculture, or other specific interest. With this up-to-date review, we attempt new perspectives rational discovery novel

Language: Английский

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The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

Molecules, Journal Year: 2018, Volume and Issue: 23(12), P. 3283 - 3283

Published: Dec. 11, 2018

Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease and Huntington’s present a major health issue financial burden for care systems around the world. The impact of these diseases will further increase over next decades due to increasing life expectancies. No cure is currently available treatment conditions; only drugs, which merely alleviate symptoms. Oxidative stress has long been associated with neurodegeneration, whether as cause or part downstream results caused by other factors. Thus, use antioxidants counter cellular oxidative within nervous system suggested potential option neurological disorders. Over last decade, significant research focused on natural target stress. However, clinical trial have lacked success patients knowledge that extracts show positive molecular activities in addition antioxidant activity, however, led their prevention treatment/management neurodegenerative diseases. This review cover several vitro vivo studies, well trials, highlight antioxidants.

Language: Английский

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Glutathione peroxidase 4: a new player in neurodegeneration?

Molecular Psychiatry, Journal Year: 2016, Volume and Issue: 22(3), P. 328 - 335

Published: Oct. 25, 2016

Language: Английский

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Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs

Frontiers in Neuroscience, Journal Year: 2020, Volume and Issue: 14

Published: June 9, 2020

Central nervous system (CNS) disorders especially neurodegenerative are the major challenge for public health and demand great attention of researchers to protect people against them. In past few decades, different treatment strategies have been adopted, but their therapeutic efficacy insufficient only shown partial mitigation symptoms further associated with severe adverse effects. Blood-brain barrier (BBB) blood-cerebrospinal fluid (BSCFB) guard CNS from harmful substances pose as challenges in delivering drugs into complications such Alzheimer’s disease, Parkinson’s Huntington’s stroke, epilepsy, brain tumors, multiple sclerosis, encephalitis, many more. Nanotechnology has come out an exciting promising new platform treating neurological potential overcome problems related conventional approaches. Molecules can be nanoengineered carry specific functions cross blood-brain barrier, target cell or signaling pathway, respond endogenous stimuli, act a vehicle gene delivery, support nerve regeneration survival. present review, role nanocarrier systems liposomes, micelles, solid lipid nanoparticles, dendrimers, nanoemulsions delivery various neurotherapeutic agents discussed, besides this, mechanism action, nanoformulation neuroprotective like curcumin, edaravone, growth factors Alzheimer’s, Parkinsonism, stroke tumors reviewed.

Language: Английский

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SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

Molecular Neurobiology, Journal Year: 2018, Volume and Issue: 55(10), P. 7987 - 8000

Published: Feb. 28, 2018

The gut-brain axis is a bidirectional communication network functionally linking the gut and central nervous system (CNS). Based on this, rational manipulation of intestinal microbiota represents novel attractive therapeutic strategy for treatment CNS-associated disorders. In this study, we explored properties probiotic formulation (namely SLAB51) in counteracting brain oxidative damages associated with Alzheimer's disease (AD). Specifically, transgenic AD mice (3xTg-AD) were treated SLAB51 effects protein oxidation, neuronal antioxidant defence repair systems monitored, particular focus role SIRT1-related pathways. We demonstrated that markedly reduced stress by activating SIRT1-dependent mechanisms, thus representing promising adjuvant treatment.

Language: Английский

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