Unmet Needs and Opportunities for Australian Innovation and Clinical Research to Improve Quality of Life and Outcomes in Patients With Peripheral Artery Disease DOI Creative Commons
Belinda Parmenter, Mary M. Kavurma, Toby Richards

et al.

Heart Lung and Circulation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Peripheral arterial disease (PAD) is characterised by atherosclerotic stenosis or occlusion of arteries that leads to reduced blood flow the limbs. PAD associated with a very high rate cardiovascular morbidity and mortality making health economic burden substantial. Despite high-quality evidence international guidelines recommending conservative medical management risk factors, exercise lifestyle interventions, surgical revascularisation (open endovascular) remains main treatment for PAD. Alarmingly, up one-third patients do not receive best therapy after surgery despite supporting this reduces events. Due considerable presents, manuscript aims identify gaps in care clinical research across Australia proposes potential collaborative solutions. In Australia, there significant disparity between rural/regional metropolitan communities. These are exacerbated inequitable access services particularly First Nation Australians, culturally linguistically diverse groups those living regional remote areas. This review identifies unmet needs multifaceted, spanning from improved understanding mechanisms, diagnostic tools stratification personalised therapy, paucity rehabilitation therapies symptoms prevention complications. Furthermore, opportunities national registries optimise trial quality outcomes. Strategies should be applied improve implementation optimal which will life, reduce costs, prevent secondary complications, limb loss, Australia's population.

Language: Английский

Unmet Needs and Opportunities for Australian Innovation and Clinical Research to Improve Quality of Life and Outcomes in Patients With Peripheral Artery Disease DOI Creative Commons
Belinda Parmenter, Mary M. Kavurma, Toby Richards

et al.

Heart Lung and Circulation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Peripheral arterial disease (PAD) is characterised by atherosclerotic stenosis or occlusion of arteries that leads to reduced blood flow the limbs. PAD associated with a very high rate cardiovascular morbidity and mortality making health economic burden substantial. Despite high-quality evidence international guidelines recommending conservative medical management risk factors, exercise lifestyle interventions, surgical revascularisation (open endovascular) remains main treatment for PAD. Alarmingly, up one-third patients do not receive best therapy after surgery despite supporting this reduces events. Due considerable presents, manuscript aims identify gaps in care clinical research across Australia proposes potential collaborative solutions. In Australia, there significant disparity between rural/regional metropolitan communities. These are exacerbated inequitable access services particularly First Nation Australians, culturally linguistically diverse groups those living regional remote areas. This review identifies unmet needs multifaceted, spanning from improved understanding mechanisms, diagnostic tools stratification personalised therapy, paucity rehabilitation therapies symptoms prevention complications. Furthermore, opportunities national registries optimise trial quality outcomes. Strategies should be applied improve implementation optimal which will life, reduce costs, prevent secondary complications, limb loss, Australia's population.

Language: Английский

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