Targeting Cancer Stem Cells in Gynecological Malignancies: Emerging Advanced Therapeutic Approaches

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Cancer stem cells (CSCs) are a crucial subpopulation in gynecological tumors, defined by their self-renewal, differentiation potential, and resistance to conventional therapies. These central tumor initiation, progression, metastasis, recurrence, making them key targets for innovative therapeutic strategies. This chapter will explore the molecular mechanisms that regulate CSCs, focusing on signaling pathways such as Wnt, Notch, Hedgehog, which critical CSC maintenance survival. It also examine emerging approaches aimed at eradicating including pathway inhibitors, immune-based strategies, combinatorial treatments. By targeting these hold promise of overcoming achieving more reliable clinical responses cancers. Further, this delves into challenges future directions translating CSC-targeted therapies practice.

Language: Английский

Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are among the most significant health concerns worldwide, characterized by neuronal dysfunction, oxidative stress, neuroinflammation, protein misfolding. Epigallocatechin gallate, a green tea polyphenol, has been reported to possess multifaceted neuroprotective properties. It reduces stress through free radical scavenging, activation of antioxidant enzymes, stabilization mitochondrial function. also inhibits neuroinflammation modulation key signaling pathways. suppresses amyloid-beta aggregation in Alzheimer’s alpha-synuclein fibrillation thus attenuating toxic accumulation. Its activity induction autophagy promotion synaptic plasticity supports survival However, low bioavailability metabolic instability hinder its translation into clinic. Strategies nanoparticle encapsulation, structural modifications, combination therapies being explored overcome these challenges. Future research could establish epigallocatechin gallate as viable candidate for managing neurodegenerative disorders.

Language: Английский

Clinical diagnosis and treatment of abdominal inflammatory myofibroblastic tumors

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 17, 2025

This study aims to summarize the clinicopathological characteristics, treatment methods, and prognosis of these patients. The goal is enhance our understanding disease provide insights for standardized diagnosis abdominal inflammatory myofibroblastic tumors(IMT). retrospective cohort included clinical data 26 patients with IMT admitted First Hospital Jilin University between January 2015 December 2023. manifestations, pathological features, prognoses were analyzed. Among patients, 6 had hepatic IMT, 2 splenic 1 wall all detected incidentally as painless masses during routine exams. Six mesenteric reported distension, pain, nausea, vomiting, low-grade fever. Of five gastric three gastrointestinal bleeding, one distension fever, dysphagia. Four small intestine cases asymptomatic obstruction symptoms. colon rectal presented intermittent hematochezia. Surgery was performed in 24 metastases received palliative therapy. During follow-up, relapsed; therapy, two surgery. At last 20 disease-free, 3 living tumors, died. Abdominal IMTs are rare, tumors favorable prognoses. Pathological examination essential diagnosis, surgery primary treatment. Adjuvant therapy depends on tumor location risk factors. Close follow-up necessary due potential recurrence metastasis.

Language: Английский