Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease

Archives of Neurology, Journal Year: 2012, Volume and Issue: 69(10), P. 1310 - 1310

Published: July 17, 2012

Background: A blood-based test that could be used as a screen for Alzheimer disease (AD) may enable early intervention and better access to treatment.Objective: To apply multiplex immunoassay panel identify plasma biomarkers of AD using samples from the Alzheimer's Disease Neuroimaging Initiative cohort.Design: Cohort study. Setting:The Biomarkers Consortium Plasma Proteomics Project.Participants: at baseline 1 year were analyzed 396 (345 year) patients with mild cognitive impairment, 112 (97 AD, 58 (54 healthy control subjects.Main Outcome Measures: Multivariate univariate statistical analyses examine differences across diagnostic groups relative apolipoprotein E (ApoE) genotype.Results: Increased levels eotaxin 3, pancreatic polypeptide, N-terminal protein B-type brain natriuretic peptide observed in patients, confirming similar changes reported cerebrospinal fluid MCI.Increases tenascin C decreases IgM ApoE also observed.All participants Apo ε3/ε4 or ε4/ε4 alleles showed distinct biochemical profile characterized by low C-reactive high cortisol, interleukin 13, B, gamma interferon levels.The use improved specificity differentiating controls, lowest whose impairment had progressed dementia.Conclusions: biomarker results confirm studies reporting increased polypeptide impairment.Incorporation yielded sensitivity specificity, supporting their usefulness screening tool.The genotype was associated unique irrespective diagnosis, highlighting importance on blood profiles.

Language: Английский

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Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia

Current Psychiatry Reviews, Journal Year: 2009, Volume and Issue: 5(2), P. 73 - 92

Published: April 29, 2009

The baby boom generation is approaching the age of greatest risk for cognitive impairment and dementia. There growing interest in strategies to modify environment midlife increase probability maintaining health late life. Several potentially modifiable factors have been studied relation dementia life, but methodological limitations observational research resulted some inconsistencies across studies. most promising are cardiovascular health, engaging mental, physical, social activities, using alcohol moderation, abstaining from tobacco use, following a heart-healthy diet. Other that may influence occupational attainment, depression, personality, exposure general anesthesia, head injury, postmenopausal hormone therapy, non-steroidal anti-inflammatory medications, nutritional supplements such as antioxidants. Some long-term studies initiated or earlier, randomized controlled trials, examined effects specific promotion behaviors on Overall, these provide limited support reduction at this time. Recommendations challenges developing effective reduce burden future discussed. Keywords: Lifestyle, cognition, Alzheimer's disease, epidemiology

Language: Английский

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Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis

JAMA Neurology, Journal Year: 2018, Volume and Issue: 75(3), P. 328 - 328

Published: Jan. 16, 2018

Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with remains unknown.

Language: Английский

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Brain-wide slowing of spontaneous alpha rhythms in mild cognitive impairment

Frontiers in Aging Neuroscience, Journal Year: 2013, Volume and Issue: 5

Published: Jan. 1, 2013

The neurophysiological changes associated with Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI) include an increase in low frequency activity, as measured electroencephalography or magnetoencephalography (MEG). A relevant property of spectral measures is the alpha peak, which corresponds to dominant rhythm. Here we studied spatial distribution MEG resting state peak amplitude values a sample 27 MCI patients 24 age-matched healthy controls. Power spectra were reconstructed source space linearly constrained minimum variance beamformer. Then, 88 Regions Interest (ROIs) defined per ROI subject was identified. Statistical analyses performed at every ROI, accounting for age, sex educational level. Peak significantly decreased (p< 0.05) MCIs many posterior ROIs. average over all ROIs 9.68±0.71 Hz controls 9.05±0.90 normalized (2.57±0.59)•10-2 (2.70±0.49)•10-2 MCIs. Age gender also found play role since its higher females than males correlated negatively age frontal Furthermore, examined dependence parameters hippocampal volume, commonly used marker early structural AD-related damage. positively volume Overall, these findings indicate pathological slowing MCI.

Language: Английский

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P300 and Neuropsychological Assessment in Mild Cognitive Impairment and Alzheimer Dementia

Frontiers in Neurology, Journal Year: 2012, Volume and Issue: 3

Published: Jan. 1, 2012

Only a small proportion of individuals with Mild Cognitive Impairment (MCI) will convert to dementia. Methods currently available identify risk for conversion do not combine enough sensitivity and specificity, which is even more problematic in low-educated populations. Current guidelines suggest the use combined markers dementia enhance prediction accuracy assessment methods. The present study adhered this proposal investigated specificity electrophysiological component P300 standard neuropsychological tests assess patients Alzheimer's disease (AD) MCI recruited from low-income country. battery comprised memory, attention, language, praxis executive functions. was recorded using classical visual odd-ball paradigm. Three variables were found achieve values above 80% (Immediate Delayed recall word list – CERAD latency P300) both AD. When they entered model together (i.e., approach) increased 96% remained high (80%). Our preliminary findings that sensitive tasks analysis may offer very useful method preclinical AD, particularly populations low socioeconomic educational levels. results provide platform justification employ resources related parameters into biological marker

Language: Английский

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Alzheimer’s Disease: A Clinical Practice-Oriented Review

Frontiers in Neurology, Journal Year: 2012, Volume and Issue: 3

Published: Jan. 1, 2012

Investigation in the field of Alzheimer´s disease (AD), commonest cause dementia, has been very active recent years and it may be difficult for clinician to keep up with all innovations aware implications they have clinical practice. The authors, thus, reviewed literature on theme order provide an updated overview, intended support decision-making aspects diagnosis management. This article begins focus concept AD its pathogenesis. Afterwards, epidemiology non-genetic risk factors are approached. Genetics, including genetic guidelines testing, mentioned next. Recommendations AD, recently proposed criteria, then reviewed. Data variants is presented. First approach patient dealt next, followed by neuropsychological evaluation. Biomarkers, namely MRI, SPECT, FDG PET, PiB CSF tau Aβ analysis, as well available data their diagnostic accuracy, also discussed. Factors predicting rate progression briefly mentioned. Finally, non-pharmacological pharmacological treatments, established emerging drugs, addressed.

Language: Английский

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The Mediating Effect of Depression in Religiosity and Cognitive Function among Chinese Muslim Elderly

Neuropsychiatry, Journal Year: 2018, Volume and Issue: 08(03)

Published: Jan. 1, 2018

The current study examined the association between religiosity and mild cognitive impairment (MCI), along with mediating role of depression, in Chinese Muslim elderly sample. 1,347 community Muslims aged 55 years or older were recruited Ningxia, China. Mini- Mental State Exam, Geriatric Depression Scale, Duke University Religion Index administered. Structural equation modeling (SEM) was used to detect mediation effect. Approximately 21.3% participants reported experiencing severe depressive symptoms 25.7% met criteria for MCI. Religiosity associated a lower risk MCI (OR=0.83, P<0.05), while depression greater (OR=1.70, P<0.01). SEM analysis revealed that significantly mediated an effect ratio 0.33 (explaining 33.0% total variance). In summary, related functioning partly due its inverse relationship Muslims.

Language: Английский

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Different Patterns of Theory of Mind Impairment in Mild Cognitive Impairment

Journal of Alzheimer s Disease, Journal Year: 2015, Volume and Issue: 45(2), P. 581 - 597

Published: March 18, 2015

Theory of Mind refers to the ability infer other’s mental states, their beliefs, intentions, or knowledge. To date, only two studies have reported presence impairment in mild cognitive (MCI). In present study,we evaluated 20 MCI patients and compared them with 25 healthy control participants using tasks. The first task was a false belief paradigm as frequently used literature, second one referential communication task,assessing real situation interaction which had never been before this population. results showed that presented difficulties inferring another person’s beliefs about reality attributing knowledge real-life interaction. Two different patterns emerged among patients. comparison group, some demonstrated isolated episodicmemory impairment, while others were impaired both tasks impacting episodic memory executive functioning. is thus altered very early stages even social interaction, could impact precociously relationships daily life.

Language: Английский

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Dual task-related gait changes in patients with mild cognitive impairment

Functional Neurology, Journal Year: 2015, Volume and Issue: unknown

Published: Jan. 1, 2015

Mild cognitive impairment (MCI) entails a high risk of developing Alzheimer's dementia.In MCI patients gait impairment, which increases the falls and institutionalization, is an early motor sign.A dualtask (DT) paradigm might improve observation this phenomenon.The aim study was to investigate motor-cognitive interference in sample group matched healthy controls submitted DT conditions.To end, three different tasks were used: counting backwards, short story recall phonemic fluency task.Overall, patients, compared with participants, performed worse on showed some degree impairment.In conditions, both groups significant disruption independently concomitant task.As regards performance, backwards worsened during dual tasking, while improved groups.Overall, our results suggest that use does not detection MCI.Our findings enhanced walking have interesting implications for rehabilitation memory function.

Language: Английский

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Variation in Variables that Predict Progression from MCI to AD Dementia over Duration of Follow-up

American journal of Alzheimer's disease, Journal Year: 2013, Volume and Issue: unknown

Published: Jan. 1, 2013

The purpose of this paper is to investigate the relative utility using neuroimaging, genetic, cerebrospinal fluid (CSF), and cognitive measures predict progression from mild impairment (MCI) Alzheimer's disease (AD) dementia over a follow-up period.The studied subjects were 139 persons with MCI enrolled in Disease Neuroimaging Initiative.Predictors AD included brain volume, ventricular hippocampal APOE ε4 two alleles, Aβ 42 , p-tau 181 /Aβ memory, language, executive function.We employ combination Cox regression analyses time-dependent receiver operating characteristic (ROC) methods assess prognostic performance stability candidate biomarkers.In demographic-adjusted multivariable model, seven measuresbrain Memory composite, Executive function composite -predicted AD. Time-dependent ROC revealed that model had an area under curve 0.832, 0.788, 0.794, 0.757 at 12, 18, 24, 36 months respectively.Supplemental models time origin set differentially 24 showed six significant predictors 12 whereas only memory predicted 18 months.The authors concluded baseline volumetric MRI selectively AD, remaining predictive even late period.These findings may inform case selection for clinical trials.

Language: Английский

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