Synthesis of a New Class of β-Carbonyl Selenides Functionalized with Ester Groups with Antioxidant and Anticancer Properties—Part II

Molecules, Journal Year: 2024, Volume and Issue: 29(12), P. 2866 - 2866

Published: June 16, 2024

A series of phenyl β-carbonyl selenides with o-ester functionality substituted on the oxygen atom chiral and achiral alkyl groups was synthesized. All compounds are first examples this type organoselenium derivatives an ester substituent in ortho position. The obtained were tested as antioxidants anticancer agents to see influence bioactivity by replacing o-amide group group. best results antioxidant agent observed for O-((1R,2S,5R)-(−)-2-isopropyl-5-methylcyclohexyl)-2-((2-oxopropyl)selanyl)benzoate. most cytotoxic derivative against breast cancer MCF-7 cell lines O-(methyl)-2-((2-oxopropyl)selanyl)benzoate human promyelocytic leukemia HL-60 O-(2-pentyl)-2-((2-oxopropyl)selanyl)benzoate.

Language: Английский

Promising aryl selenoate derivatives as antileishmanial agents and their effects on gene expression

Antimicrobial Agents and Chemotherapy, Journal Year: 2024, Volume and Issue: 68(4)

Published: March 18, 2024

Leishmaniasis remains one of the main public health problems worldwide, with special incidence in poorest populations. Selenium and its derivatives can be potent therapeutic options against protozoan parasites. In this work, 17 aryl selenoates were synthesized screened three species

Language: Английский