Glymphatic dysfunction in moyamoya disease: the influence of arterial stenosis and ventricular enlargement DOI Creative Commons
Duo Xu, Linglin Yang, Biao Jiang

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121143 - 121143

Published: March 1, 2025

The glymphatic system is a vascular-dependent network, involving cerebrospinal fluid circulation, that facilitates waste clearance from the brain. Although dysfunction has been implicated in various neurologic diseases, its influencing factors are still not fully understood. We aimed to evaluate moyamoya disease (MMD) and explore associations with arterial stenosis ventricular size. Patients MMD healthy controls were prospectively recruited undergo multi-modal MRI scans. divided into three subgroups based on initial symptoms: hemorrhagic, ischemic, other. used diffusion tensor image analysis along perivascular space (DTI-ALPS) index, magnetic resonance angiography, 3D T1-weighted images clearance, relationships between stenosis, size, ALPS index analyzed using multivariable linear regression analyses. Compared (n=39), patients (n=55) exhibited reduced (p<0.001) increased volumes of lateral ventricles (p<0.001), third ventricle fourth (p=0.013). In MMD, (standardized β=-0.283, p=0.013), volume β=-0.504, p<0.001), their interaction β=-0.606, p<0.001) all significantly associated analysis. Among subgroups, hemorrhagic subgroup had lowest (p=0.085) largest Our findings demonstrated enlarged decreased both alone synergistically enlargement would be exacerbated MMD. This evidence provides new insights mechanisms underlying impairment

Language: Английский

Glymphatic dysfunction in moyamoya disease: the influence of arterial stenosis and ventricular enlargement DOI Creative Commons
Duo Xu, Linglin Yang, Biao Jiang

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121143 - 121143

Published: March 1, 2025

The glymphatic system is a vascular-dependent network, involving cerebrospinal fluid circulation, that facilitates waste clearance from the brain. Although dysfunction has been implicated in various neurologic diseases, its influencing factors are still not fully understood. We aimed to evaluate moyamoya disease (MMD) and explore associations with arterial stenosis ventricular size. Patients MMD healthy controls were prospectively recruited undergo multi-modal MRI scans. divided into three subgroups based on initial symptoms: hemorrhagic, ischemic, other. used diffusion tensor image analysis along perivascular space (DTI-ALPS) index, magnetic resonance angiography, 3D T1-weighted images clearance, relationships between stenosis, size, ALPS index analyzed using multivariable linear regression analyses. Compared (n=39), patients (n=55) exhibited reduced (p<0.001) increased volumes of lateral ventricles (p<0.001), third ventricle fourth (p=0.013). In MMD, (standardized β=-0.283, p=0.013), volume β=-0.504, p<0.001), their interaction β=-0.606, p<0.001) all significantly associated analysis. Among subgroups, hemorrhagic subgroup had lowest (p=0.085) largest Our findings demonstrated enlarged decreased both alone synergistically enlargement would be exacerbated MMD. This evidence provides new insights mechanisms underlying impairment

Language: Английский

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