Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2023, Volume and Issue: 1(7)

Published: Aug. 27, 2023

According to the World Health Organization (WHO), coronavirus infection (COVID-19, (COronaVIrus Disease 2019) is an infectious disease caused by SARS-CoV-2 virus [1]. virus, Severe Acute Respiratory Syndrome-related 2. Initially considered pulmonary - respiratory pathology, then it turned out be poly-systemic, with multi-inflammation of many other organs, and central nervous system. Multisystem inflammatory syndrome in adults (MIS-A) [2], liver [3]. In pediatrics children (MIS-C) or PMIS-TS (Pediatric MIS temporarily associated infection) [4,5], SARS-COV-2/ COVID-19 induce Kawasaki-Like [6]. Neurological manifestations [7], recurrence meningitis without involvement [8]. Brain damage COVID primarily neurological, as a material signaling pathway COVID-infection cerebral vessels. This important, from release these patients, additional stress, suffering, stigmatization society, their isolation, intimidation, coercion (bullying) violation restriction rights. Since, concomitantly lesions cognitive deficits are component post-acute consequences (PASC), where role kynurenine significant temporary impairment [9]. The main for breakdown tryptophan amino acid, which synthesis serotonin impossible, controls cycles sleep wakefulness, precursor hormone melatonin patients COVID-19, imbalance T-helpers 1 2 leads cytokine storm that can contribute myocardial [10]. conditioned immunocompromising (IC) CHAOS [C]ardiovascular Compromise: shock; [H]omeostasis; [A]poptosis; [O]rgan Dysfunction; [S]uppression Immune System development Systemic response (SIRS) Multiple Organ Dysfunction Syndrome (MODS) [11,12]. With pronounced multiple symptoms: Electro Ion Membrane Distress (Syndrome Maria & Irina Vasilieva) [13,14] membrane electrical electromembrane paralysis; Capillary Leak Syndrome; Microcirculatory-Mitochondrial Syndrom [15,16]. Also described: Overlap mechanisms transient global amnesia [17]; Hypokalemia-stroke mimic [18]; Differential diagnosis cacosmia dysgeusia pandemic [19].

Language: Английский

Total Quality Management as Predictor of Artificial Intelligence Ensures Competitive Marketing

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2023, Volume and Issue: 1(8)

Published: Nov. 7, 2023

In the modern world Total Quality Management (TQM) respecting past ensures triumph of future and Artificial Intelligence. Fulfilling absence in universal medical journal multi-organ supportive therapy (MOST) replacement models central nervous system, immune energy system functions, have been completed by describing extracorporeal intracorporeal prosthetics functions. Prosthetics, assistive support, function contributed to foundation Intelligence (AI) creation robot as an intellect-technocrat combination. Using Da Vinci with four arms, surgeons Spain performed a lung transplant [3], relevant timely also complications COVID-19 SARS-CoV-2. As result, reduced discrepancy between predominance human technocratic intellectual factors product useful humanity. At AI is TQM recognized scientific community context alternative medicine promoter science. Thanks US development over 40 years transgenic pig organ transplantation, model conceived Moldova (1984), donor organs. The prized successfully assimilated competitive marketing, which already included, essential social financial role. IA was supported Antonio Guterres, Secretary General United Nations, Ursula von der Leyen, President European Commission. Thus has considered at level Union, Japan, China others. head Commission, Leyen from Great Britain First Safety Summit world, named 4 conditions for ensuring safety use AI. 1) A thriving independent equipped evaluate systems, funding access best supercomputers; 2) Development internationally procedure standards testing. 3) standard whereby every significant incident caused errors or misuse reported accounted for. 4) Establishment reliable international notification system.

Language: Английский

Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2024, Volume and Issue: 2(4)

Published: May 22, 2024

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores role Acute Vascular Distress Syndrome (AVDS) in development MIS both adults (MIS-A) and children (MIS-C), providing a comprehensive overview modern research treatment approaches for severe coronavirus infections. Methods Materials: synthesizes findings from multiple studies clinical reports analyze mechanisms SARS-CoV-2 induces AVDS subsequently MIS. Key materials molecular cellular data, case studies, protocols. Diagnostic tools such as PCR serological testing, well various biomarkers like neurofilament light chain galectin-3, are discussed elucidate their roles identifying managing cases. Results: interaction between host endothelial cells, mediated ACE2 receptors, triggers cascade responses leading AVDS. is characterized dysfunction, cytokine storms, mitochondrial distress, collectively contribute pathogenesis Clinical evidence indicates that critical factor severity COVID-19, with widespread implications organ systems, including central peripheral nervous systems. Conclusion: Understanding offers valuable insights into pathophysiology COVID-19. Effective management requires multifaceted approach, combining antiviral therapies, immunomodulators, supportive treatments extracorporeal membrane oxygenation (ECMO). Future should focus on targeted therapies mitigate damage improve patient outcomes

Language: Английский