Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis
Ivan Šoša,
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Loredana Labinac,
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Manuela Perković
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et al.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 2837 - 2837
Published: March 21, 2025
There
is
a
significant,
rather
than
just
anecdotal,
connection
between
the
liver
and
eyes.
This
evident
in
noticeable
cases
such
as
jaundice,
where
sclera
has
yellow
tint.
But
this
can
be
seen
through
even
more
subtle
indicators,
molecules
known
hepatokines.
relationship
not
merely
anecdotal;
some
studies,
it
referred
to
“liver–eye
axis”.
Ubiquitous
environmental
contaminants,
microplastics
(MPs),
enter
bloodstream
human
body
conjunctival
sac,
nasolacrimal
duct,
upper
respiratory
tract
mucosa.
Once
absorbed,
these
substances
accumulate
various
organs
cause
harm.
Toxic
from
surface
of
eye
lead
local
oxidative
damage
by
inducing
apoptosis
corneal
cells,
irregularly
shaped
microparticles
exacerbate
effect.
Even
other
toxicants
ocular
may
absorbed
into
distributed
throughout
body.
Environmental
toxicology
presents
challenge
because
many
pollutants
same
route
that
used
certain
medications.
Previous
research
indicated
accumulation
MPs
play
major
role
development
chronic
disease
humans.
It
crucial
investigate
whether
buildup
potential
fibrosis,
or
simply
consequence
conditions
cirrhosis
portal
hypertension.
Language: Английский
Age-Related Differences in the Mouse Corneal Epithelial Transcriptome and Their Impact on Corneal Wound Healing
Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(5), P. 21 - 21
Published: May 13, 2024
Aging
is
a
risk
factor
for
dry
eye.
We
sought
to
identify
changes
in
the
aged
mouse
corneal
epithelial
transcriptome
and
determine
how
age
affects
sensitivity,
re-epithelialization,
barrier
reformation
after
debridement.
Language: Английский
Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure
Aging,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 26, 2024
The
objective
of
this
study
was
to
investigate
the
senescent
phenotypes
human
corneal
endothelial
cells
(hCEnCs)
upon
treatment
with
ultraviolet
(UV)-A.
Language: Английский
Gene expression signatures of human senescent corneal and conjunctival epithelial cells
Aging,
Journal Year:
2023,
Volume and Issue:
15(18), P. 9238 - 9249
Published: Sept. 28, 2023
This
study
aimed
to
investigate
the
senescent
phenotypes
of
human
corneal
and
conjunctival
epithelial
cells.
Language: Английский