Oil-Encapsulated Nanoplastics from Plastic Disposable Food Containers Induce Rapid Cell Death through Cell Membrane Disruption DOI
Chao Jiang,

Ruwen Xie,

Gulimire Yilihan

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract The rise of food delivery culture has resulted in millions tons food-contact plastic containers being used each year, yet the risks micro(nano)plastics (MNPs) released during storage oil-rich foods are still not well understood. Here, we investigated MNP release from polypropylene (PP) and polyethylene (PE)-coated under simulated takeout scenarios. When exposed to cooking oil microwave heating, up 125-fold more MNPs 471-fold heavy metals compared water exposure, with significantly altered physicochemical properties. Oil-derived PP NPs, uniquely encapsulated films positive surface charge (+7.37 mV). oil-derived NPs may enhance their interaction negatively charged cell membranes, leading rapid death within 5 minutes at a concentration 100 μg/mL through membrane disruption. Transcriptomic analysis revealed that oil-PP triggered substantially extensive gene expression changes than water-derived particularly pathways related acute cellular stress mitochondrial energy metabolism. Global exposure assessments highlight annual human intake 3.35 g food. Based on integrated molecular endpoints, established benchmark dose lower limit (BMDL) 1.18 for NPs. abundance biological samples exceeds BMDL thresholds, suggesting significant health risks. Our findings reveal previously unknown mechanisms toxicity underscore urgent need stricter regulation packaging foods.

Language: Английский

Bronchoalveolar lavage fluid (BALF): Clinical applications for present and future DOI
Jie Mei, Yinong Chen, Huixiang Tian

et al.

The Innovation Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100115 - 100115

Published: Jan. 1, 2025

<p>Lungs are exposed to a wide range of complex internal and external environmental factors, creating pulmonary microenvironment that remains challenging detect interpret. Bronchoalveolar lavage fluid (BALF) contains an abundance cells, microorganisms, active substances, thus is considered be clinically promising body detection substance representative the microenvironment. The combination experimental strategies with emerging omics technologies has advanced identification interpretation microscopic components in BALF, underscoring its applications clinical detection. In summary, this review provides systematic overview development understanding discusses possible diagnosis, prediction, intervention, highlights role deciphering BALF.</p>

Language: Английский

Citations

0
Oil-Encapsulated Nanoplastics from Plastic Disposable Food Containers Induce Rapid Cell Death through Cell Membrane Disruption DOI
Chao Jiang,

Ruwen Xie,

Gulimire Yilihan

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract The rise of food delivery culture has resulted in millions tons food-contact plastic containers being used each year, yet the risks micro(nano)plastics (MNPs) released during storage oil-rich foods are still not well understood. Here, we investigated MNP release from polypropylene (PP) and polyethylene (PE)-coated under simulated takeout scenarios. When exposed to cooking oil microwave heating, up 125-fold more MNPs 471-fold heavy metals compared water exposure, with significantly altered physicochemical properties. Oil-derived PP NPs, uniquely encapsulated films positive surface charge (+7.37 mV). oil-derived NPs may enhance their interaction negatively charged cell membranes, leading rapid death within 5 minutes at a concentration 100 μg/mL through membrane disruption. Transcriptomic analysis revealed that oil-PP triggered substantially extensive gene expression changes than water-derived particularly pathways related acute cellular stress mitochondrial energy metabolism. Global exposure assessments highlight annual human intake 3.35 g food. Based on integrated molecular endpoints, established benchmark dose lower limit (BMDL) 1.18 for NPs. abundance biological samples exceeds BMDL thresholds, suggesting significant health risks. Our findings reveal previously unknown mechanisms toxicity underscore urgent need stricter regulation packaging foods.

Language: Английский

Citations

0