Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Abstract
Carbonyl‐bearing
furans,
certain
pyrroles,
and
thiophenes
were
alkylated
using
alcohols
in
an
acidic
medium.
Some
5‐alkylated
derivatives
of
2‐furoic
acid
with
various
adamantyls‐,
cycloalkyl‐,
other
2°‐
3°‐alkyl
substituents
synthesized
as
a
biomass‐derived
chemical
platform.
Side
reaction
resulted
the
substitution
carboxylic
group,
leading
to
formation
1,5‐dialkyl
furans.
In
alkylation
acyl
formyl
furan,
either
mono‐
or
di‐alkyl
products
obtained,
depending
on
functional
group
present
furan
nucleus.
Pyrroles
(or
thiophenes)
related
groups
exclusively
near‐exclusively)
yielded
mono‐alkyl
products.
The
resultant
5‐substituted
carbonyl
furans
can
be
used
building
blocks
synthetic
equivalents
for
1
C
4
synthons,
demonstrated
by
series
reactions
involving
5‐adamantan‐1‐yl‐2‐furoic
acid.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 369 - 369
Published: Jan. 3, 2025
The
synthetic
approach
based
on
a
sequence
of
Buchwald–Hartwig
cross-coupling
and
annulation
through
intramolecular
oxidative
cyclodehydrogenation
has
been
used
for
the
construction
novel
4-alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline
derivatives.
For
first
time,
these
polycyclic
compounds
were
evaluated
antimycobacterial
activity,
including
extensively
drug-resistant
strains.
A
reasonable
bacteriostatic
effect
against
Mycobacterium
tuberculosis
H37Rv
was
demonstrated.
plausible
mechanism
activity
heterocyclic
analogues
indolo[2,3-b]quinoxalines
advanced
basis
their
molecular
docking
data.
A
novel
ANRORC
type
rearrangement/intermolecular
cyclocondensation
cascade
of
5,6-dicyano-3-(2-oxo-2-ethyl)pyrazin-2(1
H
)-ones
with
hydrazine
hydrate
is
disclosed,
providing
an
efficient
strategy
synthesizing
2-(pyrazol-3-yl)imidazo[4,5-
d
]pyridazines.
ChemistryOpen,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
The
synthesis
of
pyrimido[2,1-f][1,2,4]triazines
was
performed
in
four
steps.
Compounds
obtained
by
acylation
the
starting
amino
esters
thieno[2,3-b]pyridines
were
reacted
with
various
amines.
resulting
derivatives
underwent
cyclization
presence
hydrazine
hydrate
leading
to
new
aminomethyl
thieno[3,2-d]pyrimidines.
Further
latter
resulted
unique
heterocyclic
systems:
pyrido[3'',2'':4',5']thieno[3',2':4,5]pyrimido[2,1-f][1,2,4]triazines.
uniqueness
these
systems
lies
fact
that
even
combination
last
two
cycles
represents
a
system.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(7), P. 1401 - 1401
Published: March 21, 2025
An
efficient
access
to
novel
2-substituted
1H-imidazole
derivatives
was
developed
based
on
acid-mediated
denitrogenative
transformation
of
5-amino-1,2,3-triazole
available
through
dipolar
azide−nitrile
cycloaddition
(DCR).
The
proposed
approach
includes
intramolecular
cyclization
5-amino-4-aryl-1-(2,2-diethoxyethyl)
1,2,3-triazoles
followed
by
triazole
ring
opening
and
insertion
in
situ
formed
carbene
intermediate
into
the
O-H
bond
different
alcohols
under
acidic
conditions.
Chemistry,
Journal Year:
2025,
Volume and Issue:
7(2), P. 53 - 53
Published: April 1, 2025
As
examples
of
“Click
Chemistry”,
the
reaction
1-(oxiran-2-ylmethyl)piperidine
with
several
1,2,4-triazoles
derivatives
was
studied.
a
result,
shows
that
oxirane
ring
opens
regiospecifically,
according
to
Krasusky’s
rule,
without
using
catalyst.
The
basic
nitrogen
present
in
has
catalytic
(anchimer)
effect.
