International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11435 - 11435
Published: Oct. 24, 2024
The
cycloaddition
of
nitrile
oxides
and
nitrilimines
to
one
or
both
the
C=C
double
bonds
caryophyllene
is
described.
possibility
introducing
five-membered
fused
spiro-linked
heterocycles
into
structure
sesquiterpenes
by
1,3-dipolar
reactions
was
demonstrated.
As
a
result
these
reactions,
pharmacophore
fragments
isoxazoline
pyrazoline
are
introduced
caryophyllene,
which
leads
an
increase
in
conformational
rigidity
molecule.
A
complete
stereochemical
assignment
adducts
carried
out.
study
antiviral
cytotoxic
activity
for
some
heterocyclic
derivatives
synthesized
this
work
revealed
relatively
high
biological
previously
little-studied
at
exocyclic
C=CH
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 369 - 369
Published: Jan. 3, 2025
The
synthetic
approach
based
on
a
sequence
of
Buchwald–Hartwig
cross-coupling
and
annulation
through
intramolecular
oxidative
cyclodehydrogenation
has
been
used
for
the
construction
novel
4-alkyl-4H-thieno[2′,3′:4,5]pyrrolo[2,3-b]quinoxaline
derivatives.
For
first
time,
these
polycyclic
compounds
were
evaluated
antimycobacterial
activity,
including
extensively
drug-resistant
strains.
A
reasonable
bacteriostatic
effect
against
Mycobacterium
tuberculosis
H37Rv
was
demonstrated.
plausible
mechanism
activity
heterocyclic
analogues
indolo[2,3-b]quinoxalines
advanced
basis
their
molecular
docking
data.
A
novel
ANRORC
type
rearrangement/intermolecular
cyclocondensation
cascade
of
5,6-dicyano-3-(2-oxo-2-ethyl)pyrazin-2(1
H
)-ones
with
hydrazine
hydrate
is
disclosed,
providing
an
efficient
strategy
synthesizing
2-(pyrazol-3-yl)imidazo[4,5-
d
]pyridazines.
ChemistryOpen,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
The
synthesis
of
pyrimido[2,1-f][1,2,4]triazines
was
performed
in
four
steps.
Compounds
obtained
by
acylation
the
starting
amino
esters
thieno[2,3-b]pyridines
were
reacted
with
various
amines.
resulting
derivatives
underwent
cyclization
presence
hydrazine
hydrate
leading
to
new
aminomethyl
thieno[3,2-d]pyrimidines.
Further
latter
resulted
unique
heterocyclic
systems:
pyrido[3'',2'':4',5']thieno[3',2':4,5]pyrimido[2,1-f][1,2,4]triazines.
uniqueness
these
systems
lies
fact
that
even
combination
last
two
cycles
represents
a
system.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(7), P. 1401 - 1401
Published: March 21, 2025
An
efficient
access
to
novel
2-substituted
1H-imidazole
derivatives
was
developed
based
on
acid-mediated
denitrogenative
transformation
of
5-amino-1,2,3-triazole
available
through
dipolar
azide−nitrile
cycloaddition
(DCR).
The
proposed
approach
includes
intramolecular
cyclization
5-amino-4-aryl-1-(2,2-diethoxyethyl)
1,2,3-triazoles
followed
by
triazole
ring
opening
and
insertion
in
situ
formed
carbene
intermediate
into
the
O-H
bond
different
alcohols
under
acidic
conditions.
Chemistry,
Journal Year:
2025,
Volume and Issue:
7(2), P. 53 - 53
Published: April 1, 2025
As
examples
of
“Click
Chemistry”,
the
reaction
1-(oxiran-2-ylmethyl)piperidine
with
several
1,2,4-triazoles
derivatives
was
studied.
a
result,
shows
that
oxirane
ring
opens
regiospecifically,
according
to
Krasusky’s
rule,
without
using
catalyst.
The
basic
nitrogen
present
in
has
catalytic
(anchimer)
effect.
