Targeting Prostate Cancer with Rambutan Peel-Derived Compounds via Network Pharmacology DOI Creative Commons
Wiji Utami, Trina Ekawati Tallei,

Grace L. A. Turalaki

et al.

Malacca Pharmaceutics, Journal Year: 2025, Volume and Issue: 3(1), P. 42 - 49

Published: March 27, 2025

Prostate cancer is a prevalent malignancy in men, originating the prostate gland and often driven by genetic alterations hormonal dysregulation. Rambutan (Nephelium lappaceum L.) peel, byproduct of fruit consumption, has demonstrated potential anticancer activity. This study employed network pharmacology-based silico approach to evaluate therapeutic rambutan peel extract treatment. Bioactive compounds were identified through database searches, their biological activities predicted using PASS Online. Pharmacokinetic toxicity profiles assessed ADMETLab 3.0 Protox safety drug-like properties. Potential target proteins via SwissTargetPrediction GeneCards, while protein-protein interaction networks constructed STRING. The pharmacological visualized Cytoscape elucidate molecular mechanisms action. analysis 28 bioactive extract, with 11 demonstrating activity against (Pa > 0.5). These deemed safe based on Lipinski's Rule Five (Ro5) categorized within classes V VI. was found 501 associated cancer, including key pathways involved resistance EGFR tyrosine kinase inhibitors. Network pharmacology highlighted several genes, SRC, GNAI1, PIK3CA, PIK3CD, MAPK1, MAPK3, AKT1, GNAI3, PRKCA, HSP90AA1. Among these, SRC exhibited highest centrality score, underscoring its pivotal role disrupting tumorigenic metastatic signaling pathways, suppressing cell proliferation, enhancing responses. findings suggest that holds promise as natural agent for warranting further experimental clinical validation.

Language: Английский

Targeting Prostate Cancer with Rambutan Peel-Derived Compounds via Network Pharmacology DOI Creative Commons
Wiji Utami, Trina Ekawati Tallei,

Grace L. A. Turalaki

et al.

Malacca Pharmaceutics, Journal Year: 2025, Volume and Issue: 3(1), P. 42 - 49

Published: March 27, 2025

Prostate cancer is a prevalent malignancy in men, originating the prostate gland and often driven by genetic alterations hormonal dysregulation. Rambutan (Nephelium lappaceum L.) peel, byproduct of fruit consumption, has demonstrated potential anticancer activity. This study employed network pharmacology-based silico approach to evaluate therapeutic rambutan peel extract treatment. Bioactive compounds were identified through database searches, their biological activities predicted using PASS Online. Pharmacokinetic toxicity profiles assessed ADMETLab 3.0 Protox safety drug-like properties. Potential target proteins via SwissTargetPrediction GeneCards, while protein-protein interaction networks constructed STRING. The pharmacological visualized Cytoscape elucidate molecular mechanisms action. analysis 28 bioactive extract, with 11 demonstrating activity against (Pa > 0.5). These deemed safe based on Lipinski's Rule Five (Ro5) categorized within classes V VI. was found 501 associated cancer, including key pathways involved resistance EGFR tyrosine kinase inhibitors. Network pharmacology highlighted several genes, SRC, GNAI1, PIK3CA, PIK3CD, MAPK1, MAPK3, AKT1, GNAI3, PRKCA, HSP90AA1. Among these, SRC exhibited highest centrality score, underscoring its pivotal role disrupting tumorigenic metastatic signaling pathways, suppressing cell proliferation, enhancing responses. findings suggest that holds promise as natural agent for warranting further experimental clinical validation.

Language: Английский

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