Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(10), P. 4071 - 4081
Published: Jan. 1, 2022
A
copper
decorated
covalent
organic
framework
has
been
prepared
and
identified
as
an
efficient
heterogeneous
photocatalyst
for
the
phosphorylation
of
terminal
alkynes.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(20), P. 14136 - 14148
Published: April 20, 2024
An
unprecedented
chiral
bisphosphine-catalyzed
asymmetric
Staudinger/aza-Wittig
reaction
of
2,2-disubstituted
cyclohexane-1,3-diones
is
reported,
enabling
the
facile
access
a
broad
range
cis-3a-arylhydroindoles
in
high
yields
with
excellent
enantioselectivities.
The
key
to
success
this
work
relies
on
first
application
bisphosphine
DuanPhos
reaction.
effective
reductive
system
has
been
established
address
challenging
PV═O/PIII
redox
cycle
associated
catalyst.
In
addition,
comprehensive
experimental
and
computational
investigations
were
carried
out
elucidate
mechanism
Leveraging
newly
developed
chemistry,
enantioselective
total
syntheses
several
crinine-type
Amaryllidaceae
alkaloids,
including
(+)-powelline,
(+)-buphanamine,
(+)-vittatine,
(+)-crinane,
have
accomplished
remarkable
conciseness
efficiency.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(2), P. 1083 - 1090
Published: Jan. 4, 2024
A
metal-free
and
thiol-free
organophosphorus-catalyzed
method
for
forming
thioethers
was
disclosed,
driven
by
PIII/PV═O
redox
cycling.
In
this
work,
one-step
dehydroxylative
thioetherification
of
alcohols
fulfilled
with
various
hypervalent
organosulfur
compounds.
This
established
strategy
features
an
excellent
functional
group
tolerance
broad
substrate
scope,
especially
inactivated
alcohols.
The
scale-up
reaction
further
transformation
the
product
were
also
successful.
Additionally,
offers
a
protecting-group-free
step-efficient
approach
synthesizing
peroxisome
proliferator-activated
receptor
agonists
which
exhibited
promising
potential
treating
osteoporosis
in
mammals.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
An
efficient
organophosphorus-catalyzed
thiocarbonylation
reaction
of
disulfides
with
carboxylic
acids
under
air
conditions
was
described.
Various
functional
groups
on
and
can
be
tolerated
the
present
conditions,
affording
thioesters
in
good
to
excellent
yields.
This
method
exhibited
chemoselectivity
applied
for
late-stage
functionalization
drug
molecules
containing
a
acid
group.
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
The
ongoing
discovery
of
highly
reactive
ambiphilic
main-group
species
has
significantly
advanced
the
development
chemistry,
particularly
in
realms
small
molecule
activation
and
catalysis.
Theoretically,
compounds
featuring
smaller
HOMO–LUMO
gaps
gain
stronger
ambiphilicity
higher
reactivity.
In
this
work,
we
fundamentally
demonstrate
that
Me3Sb
holds
smallest
gap
among
trimethylpnictines,
indicating
its
outstanding
ambiphilicity.
Correspondingly,
superior
reactivity
toward
deoxygenation
electron-deficient
nitroarenes
been
unambiguously
revealed
through
control
experiments.
Furthermore,
unprecedented
SbIII/SbVO
cycling
between
trialkylstibines
their
oxides
established
for
catalytic
transformation
into
azoxyarenes/azoarenes.
This
study
opens
a
new
chapter
organoantimony
derivatives
fields
redox
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 12921 - 12931
Published: Sept. 21, 2022
A
simple
visible-light-initiated
strategy
has
been
established
for
the
construction
of
organophosphorus
compounds
via
aerobic
multicomponent
reaction
α-diazoesters,
cyclic
ethers,
and
P(O)H
under
air.
number
phosphonates
phosphinates
could
be
efficiently
isolated
in
moderate
to
good
yields
without
use
photosensitizers
metal
reagents.
This
advantages
mild
condition,
operation,
eco-friendly
energy,
functional-group
tolerance,
gram-scale
synthesis.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(9), P. 6224 - 6236
Published: April 20, 2022
An
efficient
copper-catalyzed
aerobic
oxidative
cross-dehydrogenative
coupling
reaction
for
the
synthesis
of
multisubstituted
phosphorylhydrazides
from
N,N-disubstituted
hydrazines
and
hydrogen
phosphoryl
compounds
is
accomplished.
The
proceeds
under
mild
conditions
without
addition
any
external
oxidants
bases.
This
work
reported
here
represents
a
direct
P(═O)-N-N
bond
formation
with
advantages
being
operationally
simple,
good
functional
group
tolerance,
high
atom
step
economy.
Furthermore,
selected
exhibit
potential
inhibitory
activity
against
tumor
cells,
which
can
be
used
in
field
screening
anticancer
agents
as
new
chemical
entities.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(13), P. 8628 - 8635
Published: June 9, 2023
A
green
method
to
construct
C-S
bonds
using
sulfonyl
chlorides
and
alcohols/acids
via
a
PIII/PV═O
catalytic
system
is
reported.
The
organophosphorus-catalyzed
umpolung
reaction
promotes
us
propose
the
"dual-substrate
deoxygenation"
strategy.
Herein,
we
adopt
strategy,
which
achieves
deoxygenation
of
synthesize
thioethers/thioesters
driven
by
redox
cycling.
represents
an
operationally
simple
approach
stable
phosphine
oxide
as
precatalyst
shows
broad
functional
group
tolerance.
potential
application
this
protocol
demonstrated
late-stage
diversification
drug
analogues.
