Halogen Radical-Enabled Dearomatization of N-Arylpropiolamides via Photoinduced Sequential Halogenation/Spirocyclization/Oxidation Process DOI
Wenkun Luo,

Huiling Jiang,

Weiwei Luo

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Here we report a strategy that eliminates the need for photocatalysts and external additives, which provides an operable mild method halogen radical-enabled dearomatization of N-arylpropiolamides under oxygen atmosphere at room temperature. The is applicable to wide range substrates, extending beyond limited scope p-methoxyl N-phenylpropynamides. Furthermore, several functional synthetic intermediates anticancer bioactive molecules were successfully derived from 3-halogenated azaspiro[4.5]trienones.

Language: Английский

Visible-light-mediated oxidant-free tandem acylmethylation/ipso-spirocyclization of N-arylpropiolamides: Access to 3-acylmethyl azaspiro[4,5]trienones DOI

Binfeng Zhu,

Guokai Li, Mingzhu Li

et al.

Molecular Catalysis, Journal Year: 2025, Volume and Issue: 582, P. 115120 - 115120

Published: May 2, 2025

Language: Английский

Citations

0
Electrochemical Trifluoromethylation/Spirocyclization of N-Benzylacrylamides to Construct Trifluoromethylated 2-Azaspiro[4.5]decanes DOI
Zhou Lan, Hong He,

De-Qiao Yang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(3), P. 981 - 981

Published: Jan. 1, 2024

Language: Английский

Citations

1
Electrochemical Synthesis of Phosphorylated Azaspiro[4.5]di/trienones through Dearomative Spirocyclization DOI

Xiaocong Zhou,

Jian Wang, Dumei Ma

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(57), P. 7351 - 7354

Published: Jan. 1, 2024

Cp 2 Fe-mediated electrochemical synthesis of a diverse array phosphorylated azaspiro[4.5]di/trienones has been developed, which demonstrated broad substrate scope and good diastereoselectivity.

Language: Английский

Citations

0
Halogen Radical-Enabled Dearomatization of N-Arylpropiolamides via Photoinduced Sequential Halogenation/Spirocyclization/Oxidation Process DOI
Wenkun Luo,

Huiling Jiang,

Weiwei Luo

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Here we report a strategy that eliminates the need for photocatalysts and external additives, which provides an operable mild method halogen radical-enabled dearomatization of N-arylpropiolamides under oxygen atmosphere at room temperature. The is applicable to wide range substrates, extending beyond limited scope p-methoxyl N-phenylpropynamides. Furthermore, several functional synthetic intermediates anticancer bioactive molecules were successfully derived from 3-halogenated azaspiro[4.5]trienones.

Language: Английский

Citations

0