Visible-Light-Induced Divergent C–H Esterification/Alkylation of Quinoxalin-2(1H)-ones with Aldehydes under Mild Conditions
Hong Yu,
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Jun Xu,
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Chen An
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et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
27(10), P. 2526 - 2531
Published: March 5, 2025
Herein,
we
introduce
an
efficient
and
straightforward
strategy
for
the
selective
C-H
esterification
alkylation
of
quinoxalin-2(1H)-ones
with
aldehydes.
A
key
feature
our
study
is
ability
to
perform
both
using
different
types
The
reaction
system
highly
compatible
a
range
aldehydes,
yielding
C3-esterified
C3-alkylated
products
in
moderate-to-good
yields.
applicability
this
approach
further
enhanced
by
its
scalability
through
continuous-flow
synthesis,
late-stage
modification
significant
molecules,
product
derivatization.
Our
mechanistic
investigations
reveal
radical
relay
mechanism,
triggered
hydrogen
atom
transfer
process.
Language: Английский
Photo-induced aerobic cross-coupling of quinoxalin-2(1H)-ones with electron-rich thiophenes
Organic & Biomolecular Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Herein,
an
efficient
aerobic
cross-coupling
of
quinoxazolines
with
electron-rich
thiophenes
was
presented.
It's
easy
and
effective
access
to
3-thiophenyl
quinoxalinones
without
external
photo-catalyst
or
transition-metal
catalyst.
Language: Английский