Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

A copper-mediated C-H thiolation reaction of benzylamines has been developed using a transient directing group strategy. In this reaction, picolinaldehyde was used as the catalyst, which forms imine in situ with to facilitate activation. This method not only provides straightforward route aryl sulfides but also represents one rare examples first-row transition metal-mediated functionalization via approach. The work highlights potential cost-effective copper catalysts enabling challenging C-S bond formations, advancing field sustainable functionalization.

Language: Английский