Bioinformatics approach reveals the critical role of inflammation-related genes in age-related hearing loss DOI Creative Commons
Xi Gu, Chenyu Chen, Yuqing Chen

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Age-related hearing loss (ARHL) is the most prevalent sensory impairment in elderly. However, pathogenesis of ARHL remains unclear. This study was aimed to explore potential inflammation-related genes and suggest novel therapeutic targets for this condition. Initially, a total 105 Inflammatory related differentially expressed (IRDEGs) were obtained by overlapping from GSE49522 GSE49543 datasets with genes. The IRDEGs mainly enriched MAPK, PI3K-Akt, Hippo JAK-STAT pathways analysis Gene Ontology Kyoto Encyclopedia Genes Genomes. We then identified 10 key including Alox5ap, Chil1, Clec7a, Dysf, Fcgr3, etc. using Least absolute shrinkage selection operator regression converted them into human ROC curve indicated that Alox5ap expression presented high accuracy distinguishing between different groups. By CIBERSORT algorithm, 8 humanized correlated infiltration abundance 3 immune cells. Finally, it showed significantly more effective compared other variables diagnostic model ARHL. suggests inflammation might play role development ARHL, providing deeper understanding underlying causes disease.

Language: Английский

Bioinformatics approach reveals the critical role of inflammation-related genes in age-related hearing loss DOI Creative Commons
Xi Gu, Chenyu Chen, Yuqing Chen

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Age-related hearing loss (ARHL) is the most prevalent sensory impairment in elderly. However, pathogenesis of ARHL remains unclear. This study was aimed to explore potential inflammation-related genes and suggest novel therapeutic targets for this condition. Initially, a total 105 Inflammatory related differentially expressed (IRDEGs) were obtained by overlapping from GSE49522 GSE49543 datasets with genes. The IRDEGs mainly enriched MAPK, PI3K-Akt, Hippo JAK-STAT pathways analysis Gene Ontology Kyoto Encyclopedia Genes Genomes. We then identified 10 key including Alox5ap, Chil1, Clec7a, Dysf, Fcgr3, etc. using Least absolute shrinkage selection operator regression converted them into human ROC curve indicated that Alox5ap expression presented high accuracy distinguishing between different groups. By CIBERSORT algorithm, 8 humanized correlated infiltration abundance 3 immune cells. Finally, it showed significantly more effective compared other variables diagnostic model ARHL. suggests inflammation might play role development ARHL, providing deeper understanding underlying causes disease.

Language: Английский

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