Mast cells: key players in digestive system tumors and their interactions with immune cells

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 15, 2025

Abstract Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health the pathophysiology various illnesses, including allergies, cardiovascular diseases autoimmune diseases. Recent studies tumor-related research have demonstrated that mast exert substantial influence on tumor cell behavior microenvironment, exhibiting pro- anti-tumor effects. Specifically, not only secrete mediators related to pro-tumor function such as trypsin-like enzymes, chymotrypsin, vascular endothelial growth factor histamine, but also progression cystatin C IL-17F. This dual renders them an under-recognized very promising target for immunotherapy. Digestive system tumors, characterized by high morbidity associated mortality rates globally, increasingly recognized healthcare burden. paper examines cell-derived development tumors digestive system. It explores prognostic significance patients with gastrointestinal cancers at different stages disease. Additionally, article investigates interactions between cells, well potential relationships among intratumoral bacteria, within microenvironment. The aim is propose new strategies immunotherapy targeting cells.

Language: Английский

Expanding the scope of mast cell disease: Does mast cell‐derived TNF play a role in immune‐mediated chronic illness and autoimmunity?

Rheumatology & autoimmunity, Journal Year: 2024, Volume and Issue: 4(4), P. 218 - 225

Published: Dec. 1, 2024

Abstract Increasing evidence underscores the vital significance of diverse mast cell mediators in inflammatory illness, yet diagnostic criteria for activation syndrome still focus predominantly on a solitary mediator, tryptase. Therapeutic interventions, conversely, tend to prioritize histamine, prostaglandins, and leukotrienes. This article, via review both experimental clinical findings, spotlights mechanisms action an important mediator – tumor necrosis factor (TNF), elucidates intricate linkages between dysfunction, chronic autoimmunity. After providing overview role cell‐derived TNF illnesses viral infections, we hypothesize interplay mitochondrial microglial activation, hypothalamic‐pituitary‐adrenal axis pathways cells treatments such as high‐dose melatonin low‐dose naltrexone.

Language: Английский