Long non-coding rnas as key modulators of the immune microenvironment in hepatocellular carcinoma: implications for Immunotherapy DOI Creative Commons
Siqi Zhao, Fei Chen, Lingyu Hu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Hepatocellular carcinoma (HCC) represents a major global health challenge, characterized by its complex immune microenvironment that plays pivotal role in tumor progression and therapeutic response. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of various biological processes, including gene expression cell function. This review explores the multifaceted roles lncRNAs modulating HCC. We discuss how influence infiltration activation cells, shape cytokine profiles, regulate checkpoint molecules, thereby affecting tumor's immunogenicity response to immunotherapy. Furthermore, we highlight specific implicated evasion mechanisms their potential biomarkers targets. By elucidating intricate interplay between landscape HCC, this aims provide insights into novel strategies for enhancing immunotherapeutic efficacy improving patient outcomes.

Language: Английский

Long non-coding rnas as key modulators of the immune microenvironment in hepatocellular carcinoma: implications for Immunotherapy DOI Creative Commons
Siqi Zhao, Fei Chen, Lingyu Hu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Hepatocellular carcinoma (HCC) represents a major global health challenge, characterized by its complex immune microenvironment that plays pivotal role in tumor progression and therapeutic response. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of various biological processes, including gene expression cell function. This review explores the multifaceted roles lncRNAs modulating HCC. We discuss how influence infiltration activation cells, shape cytokine profiles, regulate checkpoint molecules, thereby affecting tumor's immunogenicity response to immunotherapy. Furthermore, we highlight specific implicated evasion mechanisms their potential biomarkers targets. By elucidating intricate interplay between landscape HCC, this aims provide insights into novel strategies for enhancing immunotherapeutic efficacy improving patient outcomes.

Language: Английский

Citations

0