Ion Channel Regulation in Caveolae and Its Pathological Implications DOI Creative Commons

Jianyi Huo,

Long Mo, Xiaojing Lv

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 631 - 631

Published: April 24, 2025

Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation. These composed of caveolin protein family enriched cholesterol sphingolipids, creating a unique lipid microdomain. contribute to functional regulation various channels through both physical interactions involvement complex signaling networks. Ion localized caveolae involved processes such as generation propagation action potentials, responses mechanical forces, metabolism. Dysregulation function has been linked development diseases, including cardiovascular disorders, neurodegenerative metabolic syndrome, cancer. This review summarizes channel caveolae, their pathological implications, offering new insights into potential therapeutic targets for channel-related diseases.

Language: Английский

Ion Channel Regulation in Caveolae and Its Pathological Implications DOI Creative Commons

Jianyi Huo,

Long Mo, Xiaojing Lv

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 631 - 631

Published: April 24, 2025

Caveolae are distinctive, flask-shaped structures within the cell membrane that play critical roles in cellular signal transduction, ion homeostasis, and mechanosensation. These composed of caveolin protein family enriched cholesterol sphingolipids, creating a unique lipid microdomain. contribute to functional regulation various channels through both physical interactions involvement complex signaling networks. Ion localized caveolae involved processes such as generation propagation action potentials, responses mechanical forces, metabolism. Dysregulation function has been linked development diseases, including cardiovascular disorders, neurodegenerative metabolic syndrome, cancer. This review summarizes channel caveolae, their pathological implications, offering new insights into potential therapeutic targets for channel-related diseases.

Language: Английский

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