Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response DOI Creative Commons
Chunlei Zhang, Yong Wang, Lei Cheng

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 5, 2025

Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence tumor immune surveillance responses to immunotherapies chemotherapy in CRC. We highlight role specific microbial taxa promoting or inhibiting growth potential microbiota-based biomarkers for predicting treatment efficacy. The also discusses implications modulation strategies, including diet, probiotics, fecal transplantation, personalized management. By critically evaluating literature, we aim provide comprehensive understanding microbiota’s dual inform future research directions this field.

Language: Английский

Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response DOI Creative Commons
Chunlei Zhang, Yong Wang, Lei Cheng

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 5, 2025

Colorectal cancer (CRC) poses a significant global health burden, with gut microbiota emerging as crucial modulator of CRC pathogenesis and therapeutic outcomes. This review synthesizes current evidence on the influence tumor immune surveillance responses to immunotherapies chemotherapy in CRC. We highlight role specific microbial taxa promoting or inhibiting growth potential microbiota-based biomarkers for predicting treatment efficacy. The also discusses implications modulation strategies, including diet, probiotics, fecal transplantation, personalized management. By critically evaluating literature, we aim provide comprehensive understanding microbiota’s dual inform future research directions this field.

Language: Английский

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