Cancer-Associated Fibroblasts as the “Architect” of the Lung Cancer Immune Microenvironment: Multidimensional Roles and Synergistic Regulation with Radiotherapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3234 - 3234

Published: March 31, 2025

Cancer-associated fibroblasts (CAFs), as the “architect” of immune microenvironment in lung cancer, play a multidimensional role tumor progression and regulation. In this review, we summarize heterogeneity origin molecular phenotype CAFs explore complex interactions between multiple components microenvironment, including regulatory relationships with innate cells (e.g., tumor-associated macrophages, neutrophils), adaptive T cells), extracellular matrix (ECM). significantly influence immunomodulation through secretion cytokines, remodeling ECM, regulation cell function affects escape treatment resistance tumors. addition, review also deeply explored synergistic relationship CAF radiotherapy, revealing key radiotherapy-induced which provides new perspective for optimizing comprehensive strategy cancer. By comprehensively analyzing roles its interaction aims to provide theoretical basis precise clinical

Language: Английский

Biomarkers of success of anti-PD-(L)1 immunotherapy for non-small cell lung cancer derived from RNA- and whole-exome sequencing: results of a prospective observational study on a cohort of 85 patients

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 11, 2024

Immune checkpoint inhibitors (ICIs) treatment have shown high efficacy for about 15 cancer types. However, this therapy is only effective in 20-30% of patients. Thus, the precise biomarkers ICI response are an urgent need.

Language: Английский