Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Osteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology related to local accumulation senescent cells (SnCs). However, existing SnCs-scavenging drugs "senolytics" may lead exhaustion stem and progenitor cells, impairing chondrocyte proliferation cartilage regeneration. Here, ADAM19, a kind endopeptidases from ADAM (a disintegrin metalloproteinase) family, identified as novel target for rejuvenation. ADAM19 elevated in chondrocytes both mice human osteoarthritic joints, well cellular senescence model vitro. knockdown not only significantly attenuated phenotype chondrocytes, but also promoted cell extracellular matrix synthesis. RNA sequencing revealed regulate mainly through PI3K/AKT signal axis. In addition, senescence-targeting small interfering (siRNA) delivery system developed vivo therapeutic siRNA. The complex selectively released siRNA SnCs performed high silencing effect on gene. Furthermore, intra-articular (IA) injection once every two weeks OA effectively reduced hyaline This study provides promising strategy development regenerative interference therapy.

Language: Английский

The emerging roles of LINC00511 in breast cancer development and therapy

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 14, 2024

Breast cancer (BC) is associated with malignant tumors in women worldwide persistently high incidence and mortality rates. The traditional therapies including surgery, chemotherapy, radiotherapy targeted therapy have certain therapeutic effects on BC patients, but acquired drug resistance can lead to tumor recurrence metastasis. This remains a clinical challenge that difficult solve during treatment. Therefore, continued research needed identify effective targets treatment methods, ultimately implement personalized strategies. Several studies implicated the long non-coding RNA LINC00511 closely linked occurrence, development of BC. Here we will review structure mechanisms action lnc various cancers, then explore its expression related regulatory In addition, discuss biological functions potential applications

Language: Английский

Expression profile of microRNAs in bovine lymphocytes infected with Theileria annulata and treated with buparvaquone

Parasitology Research, Journal Year: 2024, Volume and Issue: 123(9)

Published: Sept. 1, 2024

Language: Английский