Study on the Relationship between Cerebral Blood Perfusion, Neuronal Cytokines and Cognitive Function in Patients with Alzheimer's Disease DOI Open Access

Hongjiang Lu,

Yuan Fang, Xuebo Chen

et al.

Actas Españolas de Psiquiatría, Journal Year: 2024, Volume and Issue: 52(3), P. 238 - 247

Published: June 5, 2024

Background: Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the progressive emergence of multiple cognitive deficits. Early diagnosis great significance for intervention and treatment AD. The objective this study to explore relationship between cerebral blood perfusion, neuronal cytokines function in patients with Methods: AD admitted 903 Hospital People's Liberation Army Joint Logistics Support Force from June 2020 January 2023 were retrospectively selected as objects, 65 healthy people who underwent physical examination during same period included control group. Subjects both groups 3.0 T magnetic resonance imaging (MRI) observe their perfusion parameters. level was assessed using Montreal Cognitive Assessment (MoCA). Venous collected groups, serum levels brain-derived factor (BDNF) glial cell-derived neurotrophic (GDNF) measured enzyme-linked immunosorbent assay (ELISA). correlation BDNF GDNF parameters MoCA score group analyzed Spearman analysis. Results: flow signal intensity left frontal lobe, right temporal parietal occipital lobe observation significantly lower than that (p < 0.001). visuospatial, executive functions, naming, attention, language function, abstract generalization ability, memory orientation, total scale scores those results analysis showed positively correlated patients, statistically significant 0.05). Conclusion: In people. Cerebral patients.

Language: Английский

Study on the Relationship between Cerebral Blood Perfusion, Neuronal Cytokines and Cognitive Function in Patients with Alzheimer's Disease DOI Open Access

Hongjiang Lu,

Yuan Fang, Xuebo Chen

et al.

Actas Españolas de Psiquiatría, Journal Year: 2024, Volume and Issue: 52(3), P. 238 - 247

Published: June 5, 2024

Background: Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the progressive emergence of multiple cognitive deficits. Early diagnosis great significance for intervention and treatment AD. The objective this study to explore relationship between cerebral blood perfusion, neuronal cytokines function in patients with Methods: AD admitted 903 Hospital People's Liberation Army Joint Logistics Support Force from June 2020 January 2023 were retrospectively selected as objects, 65 healthy people who underwent physical examination during same period included control group. Subjects both groups 3.0 T magnetic resonance imaging (MRI) observe their perfusion parameters. level was assessed using Montreal Cognitive Assessment (MoCA). Venous collected groups, serum levels brain-derived factor (BDNF) glial cell-derived neurotrophic (GDNF) measured enzyme-linked immunosorbent assay (ELISA). correlation BDNF GDNF parameters MoCA score group analyzed Spearman analysis. Results: flow signal intensity left frontal lobe, right temporal parietal occipital lobe observation significantly lower than that (p < 0.001). visuospatial, executive functions, naming, attention, language function, abstract generalization ability, memory orientation, total scale scores those results analysis showed positively correlated patients, statistically significant 0.05). Conclusion: In people. Cerebral patients.

Language: Английский

Citations

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