The Impact of Walking on BDNF as a Biomarker of Neuroplasticity: A Systematic Review

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 254 - 254

Published: Feb. 27, 2025

Background/Objectives: The brain-derived neurotrophic factor (BDNF) is a critical exercise-induced modulator of various neuroplasticity processes, including adult hippocampal neurogenesis. Environmental affordance for physical activity novel theory that aims to increase the BDNF through walking or climbing stairs, stimulated by urban and interior environment. In systematic review, this paper explores association between walking, as structured free-living form activity, changes in humans with healthy locomotion. Method: A review registered protocol, INPLASY2024110093, following PRISMA guidelines, includes English-language original research articles on older human subjects who are locomotor-healthy, studies exercise presented non-combined intervention, must report dependent variable. search was conducted using three databases: PubMed, Web Science, Scopus, resulting 21 eligible studies. Results: This finds impact evidenced, but subject moderate high intensities single bouts. At same time, long-term effects yet be fully understood, potentially due uptake functional brain improvements, muscle repair, instead an accumulation itself, still confirm important role neurosustainability. Age environmental factors such heat also found affect BDNF. narrative synthesis provides elaborate explanations understanding those complex dynamics before reaching future conclusions concentrations. Conclusions: highlights potential played moderate- high-intensity lifestyle intervention can utilised built environment promote adaptive changes, sustainable regulation

Language: Английский

Impact of structured exercise interventions on health outcomes in drug rehabilitation patients: a comparative study of open and closed exercises

Journal of Addictive Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Dec. 5, 2024

This study investigates the effects of open and closed exercise interventions on physical mental health individuals undergoing substance use disorder (SUD). We examined changes in tendency recurrence use, vital capacity (VC), resting heart rate (RHR), sleep quality, choice reaction time.

Language: Английский

Neuroplasticity in Depressive Disorders: The Role of BDNF in Linking Pharmacotherapy and Physical Activity

Quality in Sport, Journal Year: 2024, Volume and Issue: 36, P. 56457 - 56457

Published: Dec. 14, 2024

Introduction: Depressive disorders are among the most prevalent mental health conditions globally, affecting millions of people. Despite extensive research, exact pathophysiology depression remains unclear. Recent evidence suggests that neuroplasticity, particularly role brain-derived neurotrophic factor (BDNF), plays a crucial in both onset and treatment depressive disorders. Aim Study: This review explores relationship between neuroplasticity depression, focusing on BDNF as central biomarker potential therapeutic target. It also examines how antidepressant therapies physical activity influence levels, offering insights into novel approaches for treating Material Methods: A literature was conducted using PubMed Google Scholar databases, peer-reviewed articles with keywords: "neuroplasticity", "BDNF", "depression", "antidepressants" "physical activity". Conclusions: Neuroplasticity, through signaling, critical pathogenesis depression. Elevated levels promote synaptic plasticity, neurogenesis, recovery brain function. Antidepressant treatments enhance by increasing levels. Antidepressants neuroplastic processes, serving key mediator.

Language: Английский