Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression DOI Creative Commons
Bin Fan,

Gangxian Chen,

Shu‐Yi Huang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 9, 2025

The most common form of internal RNA modification in eukaryotes is called n6-methyladenosine (m6A) methylation. It has become more and well-known as a research issue recent years since it alters metabolism involved numerous biological processes. Currently, m6A alteration offers new opportunities clinical applications intimately linked to carcinogenesis. Ferroptosis-a iron-dependent, lipid peroxidation-induced regulated cell death-was discovered. In the development cancer, an important factor. According newly available data, ferroptosis regulates tumor growth, cancer exhibits aberrant levels crucial regulatory components. On other hand, multiple roles tumors, relationship between m6A-modified malignancies quite intricate. this review, we first give thorough review functional methylation, focusing on molecular processes through regulation human progression metastasis, which are strongly associated initiation, progression, drug resistance. Therefore, clarify m6A-mediated providing strategy for treatment with substantial implications.

Language: Английский

Summary of the mechanism of ferroptosis regulated by m6A modification in cancer progression DOI Creative Commons
Bin Fan,

Gangxian Chen,

Shu‐Yi Huang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 9, 2025

The most common form of internal RNA modification in eukaryotes is called n6-methyladenosine (m6A) methylation. It has become more and well-known as a research issue recent years since it alters metabolism involved numerous biological processes. Currently, m6A alteration offers new opportunities clinical applications intimately linked to carcinogenesis. Ferroptosis-a iron-dependent, lipid peroxidation-induced regulated cell death-was discovered. In the development cancer, an important factor. According newly available data, ferroptosis regulates tumor growth, cancer exhibits aberrant levels crucial regulatory components. On other hand, multiple roles tumors, relationship between m6A-modified malignancies quite intricate. this review, we first give thorough review functional methylation, focusing on molecular processes through regulation human progression metastasis, which are strongly associated initiation, progression, drug resistance. Therefore, clarify m6A-mediated providing strategy for treatment with substantial implications.

Language: Английский

Citations

0