Curcumol inhibits the malignant progression of prostate cancer and regulates the PDK1/AKT/mTOR pathway by targeting miR‑9 DOI Creative Commons
Wen S. Sheng, Wenjing Xu, Jin Ding

et al.

Oncology Reports, Journal Year: 2021, Volume and Issue: 46(5)

Published: Sept. 28, 2021

Curcumol has been reported to exert anti‑tumor activity, but its intrinsic molecular mechanism in prostate cancer remains be elucidated. The present study aimed analyze the effect of curcumol on and identify possible internal regulatory pathway using in vitro cell culture vivo tumor model experiments. cytotoxicity was detected a Cell Counting Kit‑8 assay it found that had no obvious toxicity or side effects RWPE‑1 cells. Wound healing, Transwell flow cytometry assays demonstrated could affect activity PC3 luciferase reporter also indicated microRNA (miR)‑9 directly target pyruvate dehydrogenase kinase 1 (PDK1). After cells were transfected with miR‑9 inhibitor treated curcumol, expression levels PDK1/AKT/mTOR signaling pathway‑related proteins [PDK1, phosphorylated (p)‑AKT p‑mTOR] increased decreased, respectively. Next, xenograft established. Tumor size factors altered following treatment curcumol. experiments collectively inhibit by upregulating level miR‑9. regulates via affects development cancer. These findings provide scientific insight for research into treatments

Language: Английский

Curcumol Enhances the Antitumor Effect of Lenvatinib on Hepatocellular Carcinoma Cells DOI Open Access

ZhaoLi Wu,

Jia Wang

Discovery Medicine, Journal Year: 2024, Volume and Issue: 36(180), P. 199 - 199

Published: Jan. 1, 2024

Background: Lenvatinib is an important molecular target drug for the treatment of advanced hepatocellular carcinoma (HCC). However, application targeted therapies HCC also faces some challenges. Cumulative evidence has shown that curcumol a potential anti-HCC drug. Curcumol can be used as chemosensitizer to enhance antitumor effect chemotherapeutic drugs. The purpose our study explore combined with lenvatinib on HCC. Methods: effects or/and Huh 7 cells cell line were examined using counting kit-8 (CCK-8) assay, colony formation and transwell assay. For in vivo investigation, subcutaneous growth was determined in nude mice. Changes autophagy by transmission electron microscope (TEM). Protein levels apoptotic-related factors, epithelial mesenchymal transition (EMT)-related N-cadherin janus tyrosine kinase 2 (JAK2)/signal transducers activators transcription 3 (STAT3) Western blot. Results: In this study, we found or could promote apoptosis vitro inhibit tumors vivo (curcumol group compared control group, p < 0.05). While combination improve promoting inhibiting (combination 0.05). induce more autolysosome detected TEM. Mechanically, increase expression Bcl-2-associated X protein (Bax), E-cadherin, UNC-51-like 1 (ULK), microtubule-associated light chain (LC3B) II/I, whereas it reduced B-cell lymphoma-2 (Bcl-2), JAK2/STAT3 (curcumol Furthermore, Bax, ULK, LC3B Bcl-2, N-cadherin, These findings suggest enhances cells. Conclusion:

Language: Английский

Citations

8
Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective DOI Creative Commons
Yansong Fu, Zhipeng Wang, Hong Qin

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(4), P. 218 - 218

Published: April 12, 2024

Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent worldwide, affecting approximately two-fifths of global population. The pathogenesis MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play a pivotal role in progression MAFLD, including lipids, carbohydrates, amino acids, micronutrients. In recent years, medicinal properties natural products have attracted widespread attention, numerous studies reported their efficacy ameliorating subsequently alleviating MAFLD. This review aims summarize metabolic-associated pathological mechanisms as well regulate pathways alleviate

Language: Английский

Citations

8
Curcumol ameliorates neuroinflammation after cerebral ischemia–reperfusion injury via affecting microglial polarization and Treg/Th17 balance through Nrf2/HO-1 and NF-κB signaling DOI Creative Commons
Ying Liu, Wen Wang,

Bohan Di

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 24, 2024

Abstract Neuroinflammation caused by microglia and other immune cells plays pivotal role in cerebral ischemia/reperfusion injury recovery. Modulating microglial polarization or Treg/Th17 balance from pro-inflammatory phenotype to anti-inflammatory are promising strategies for the treatment of ischemia. Curcumol has potential fight against oxidative stress inflammation, but whether it protective effect ischemia is uncertain. In present study, was induced C57BL/6 mice via middle artery occlusion (MCAO). MCAO were treated with curcumol 7 days, then post-stroke ischemic injury, neurological deficits, brain leukocyte infiltration evaluated TTC staining, behavioural tests, flow cytometry, western blot immunofluorescence. We found that poststroke administration reduced infarct volume, attenuated neuronal damage improved motor function recovery mice. skewed toward vivo after oxygen-glucose deprivation reoxygenation (OGD/R) vitro. addition, local T cell impaired balance. inhibited ROS production regulated Nrf2/HO-1 NF-κB signaling microglia. Finally, inhibiting activating abrogated influence on polarization. conclusion, neuroinflammation modulating through signaling. might be a strategy stroke patients.

Language: Английский

Citations

8
Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects DOI Creative Commons
Ting Cui, Boyu Li, Fei Liu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 387 - 387

Published: March 23, 2024

Curcumae Rhizoma, a traditional Chinese medicine with wide range of pharmacological activities, is obtained from the dried rhizomes Curcuma phaeocaulis VaL., kwangsiensis S. G. Lee et C. F. Liang, and wenyujin Y. H. Chen Ling. Sesquiterpenoids curcuminoids are found to be main constituents Rhizoma. composed three isoprene units susceptible complex transformations, such as cyclization, rearrangement, oxidation. They most structurally diverse class plant-based natural products biological activities widely in nature. In recent years, scholars have conducted abundant studies on structures properties components This article elucidates chemical structures, medicinal properties, sesquiterpenoids (a total 274 compounds) isolated We summarized extraction isolation methods for sesquiterpenoids, established component library analyzed structural variances among sourced Rhizoma botanical origins. Furthermore, our investigation reveals array sesquiterpenoid types, encompassing guaiane-type, germacrane-type, eudesmane-type, elemane-type, cadinane-type, carane-type, bisabolane-type, humulane-type, other emphasizing relationship between diversity activity. hope provide valuable reference further research exploitation pave way development new drugs derived plants.

Language: Английский

Citations

7
Role of Curcuma longae Rhizoma in medical applications: research challenges and opportunities DOI Creative Commons
Peng Zhang,

Hong Liu,

Yu Yuan

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 6, 2024

Curcuma longae Rhizoma, commonly known as turmeric, is extensively utilized not only in Traditional Chinese Medicine (TCM) but also across various traditional medicine systems worldwide. It renowned for its effectiveness removing blood stasis, promoting circulation, and relieving pain. The primary bioactive metabolites of Rhizoma-curcumin, β-elemene, curcumol, curdione-have been studied their pharmacological benefits. These include anti-tumor properties, cardiovascular cerebrovascular protection, immune regulation, liver roles analgesics, anti-inflammatories, antivirals, antibacterials, hypoglycemics, antioxidants. This review critically examines the extensive body research regarding mechanisms action which engages multiple molecular targets signaling pathways such NF-κB, MAPKs, PI3K/AKT. core objective this to assess how main active turmeric interact with these achieve therapeutic outcomes clinical settings. Furthermore, we discuss challenges related bioavailability explore potential methods enhance effects. By doing so, aims provide fresh insights into optimization Rhizoma broader applications.

Language: Английский

Citations

7
Comprehensive Metabolome Analysis of Fermented Aqueous Extracts of Viscum album L. by Liquid Chromatography−High Resolution Tandem Mass Spectrometry DOI Creative Commons
Evelyn Maribel Condori Peñaloza, Carla Holandino,

Claudia Scherr

et al.

Molecules, Journal Year: 2020, Volume and Issue: 25(17), P. 4006 - 4006

Published: Sept. 2, 2020

Fermented aqueous extracts of

Language: Английский

Citations

41
Effects of icariin and curcumol on autophagy, ferroptosis, and lipid metabolism based on miR‐7/m‐TOR/SREBP1 pathway on prostate cancer DOI
Wenjing Xu, Jin Ding, Bonan Li

et al.

BioFactors, Journal Year: 2022, Volume and Issue: 49(2), P. 438 - 456

Published: Dec. 30, 2022

This study aimed to investigate the effects and underlying molecular mechanisms of icariin (ICA) curcumol on autophagy, ferroptosis, lipid metabolism in prostate cancer (PCa), vitro vivo. Normal epithelial cells RWPE-1 PCa cell lines DU145 PC-3 were treated with ICA curcumol. Ferrostatin-1 (Fer-1) or 3-MA was added treat cells. In addition, we knocked down miR-7. The mechanism after knockdown miR-7 verified by nude mice tumorigenesis experiments. had no significant effect viability cells, but there a difference between After treatment curcumol, proliferation inhibited, apoptosis, reactive oxygen species (ROS) levels, expression increased. combined more effect. induced autophagy ferroptosis si-miR-7 reversed ferroptosis. MiR-7 targeted mTOR regulated mTOR/SREBP1 pathway may affect affecting SREBP1. synergistically miR-7/mTOR/SREBP1 induce affected metabolism.

Language: Английский

Citations

23
Blockade of KLF5/LDH—A feedback loop contributes to Curcumol inhibition of sinusoidal endothelial cell glycolysis and mitigation of liver fibrosis DOI
Yang Li, Yuanyuan Zhou,

Siwei Xia

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 114, P. 154759 - 154759

Published: March 22, 2023

Language: Английский

Citations

16
Characterization and Evaluation of Silk Sericin-Based Hydrogel: A Promising Biomaterial for Efficient Healing of Acute Wounds DOI Creative Commons

Fariha Munir,

Hafiz Muhammad Tahir, Shaukat Ali

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(35), P. 32090 - 32098

Published: Aug. 23, 2023

The present study was aimed to prepare the potent silk sericin-based hydrogels in combination with plant extracts (curcumin and banana peel powder) silver nanoparticles (AgNPs) accelerate acute wound healing process. Experimental excision wounds were created mice by biopsy puncture, potential of sericin (2%)-based hydrogel its combinations curcumin (2%), powder AgNPs (2%) estimated calculating percent contraction, time, histology skin tissues, different biochemical tests. results showed that treated significantly (P < 0.001) high contraction as compared negative control, healed 11 days. histological evaluation also covered more than uncovered wounds. Furthermore, tests revealed treatment groups a significant decrease serum level pro-inflammatory cytokines (IL-6). A increase anti-inflammatory (IL-10) anti-oxidant enzymes observed groups. highest containing powder, leaving behind commercially available ointment polyfax (positive control). It can be concluded extract used natural biomaterials dressing for rapid

Language: Английский

Citations

15
Network Pharmacology and Comparative Transcriptome Reveals Biotargets and Mechanisms of Curcumol Treating Lung Adenocarcinoma Patients With COVID-19 DOI Creative Commons
Lu Yang, Hao Xiong, Xin Li

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: April 19, 2022

The coronavirus disease 2019 (COVID-19) pandemic has led to 4,255,892 deaths worldwide. Although COVID-19 vaccines are available, mutant forms of severe acute respiratory syndrome 2 (SARS-CoV-2) have reduced the effectiveness vaccines. Patients with cancer more vulnerable than patients without cancer. Identification new drugs treat could reduce mortality rate, and traditional Chinese Medicine(TCM) shown potential in treatment. In this study, we focused on lung adenocarcinoma (LUAD) COVID-19. We aimed investigate use curcumol, a TCM, LUAD COVID-19, using network pharmacology systematic bioinformatics analysis. results showed that share cluster common deregulated targets. analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, TTK) curcumol LUAD. Clinicopathological these demonstrated expression is associated poor patient survival rates. further highlighted involvement target DNA damage response, chromosome stability, pathogenesis More importantly, influence cell-signaling Warburg effect, which supports SARS-CoV-2 replication inflammatory response. Comparative transcriptomic vitro cell validated effect for treating through control cycle This study earlier findings treatment

Language: Английский

Citations

20