Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future DOI Creative Commons
Zhaomu Zeng, Xiuchao Geng, Xichao Wen

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 14, 2023

Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant pneumonia in December 2019, cumulative number infected people worldwide has exceeded 670 million, with over 6.8 million deaths. Despite marketing multiple series vaccines implementation strict prevention control measures many countries, spread prevalence SARS-CoV-2 have not been completely effectively controlled. The latest research shows that addition to angiotensin converting enzyme II (ACE2), dozens protein molecules, including AXL, can act as host receptors for infecting human cells, virus mutation immune evasion never seem stop. To sum up, this review summarizes organizes relevant literature, comprehensively reviews genome characteristics well receptor-based pathogenesis (including ACE2 other new receptors), evasion, vaccine development aspects, proposes a treatment opinions. It is expected provide theoretical basis an in-depth understanding pathogenic mechanism along ideas diagnosis classification, COVID-19-related disease drug development.

Language: Английский

The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology, and Variants of Concern DOI
Paul C. Guest, Prashant Kesharwani, Alexandra E. Butler

et al.

Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 3 - 26

Published: Jan. 1, 2023

Language: Английский

Citations

6
The binding profile of SARS‐CoV‐2 with human leukocyte antigen polymorphisms reveals critical alleles involved in immune evasion DOI
Yan Zhan,

Ling Ye,

Qianying Ouyang

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(9)

Published: Sept. 1, 2023

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), astonished world and led to millions of deaths. Due viral new mutations immune evasion, SARS-CoV-2 ranked first in transmission influence. binding affinity human leukocyte antigen (HLA) polymorphisms might be related escape, but mechanisms remained unclear. In this study, we obtained strains with different HLA proteins identified 31 risk alleles. Subsequent structural predictions 10 active sites these that may promote evasion. Particularly, also found weak ability class I could contribute evasion Omicron. These findings suggest important implications for preventing providing insights vaccine design.

Language: Английский

Citations

6
SARS-CoV-2 Variants Monitoring Using Real-Time PCR DOI Creative Commons
A. S. Esman, Anna S. Cherkashina, К. О. Миронов

et al.

Diagnostics, Journal Year: 2022, Volume and Issue: 12(10), P. 2388 - 2388

Published: Oct. 1, 2022

According to the temporary recommendations of 2021 World Health Organization (WHO), in addition whole-genome sequencing, laboratories various countries can also screen for known mutations utilizing targeted RT-PCR-based mutation detection assays. The aim this work was generate a laboratory technique differentiate main circulating SARS-CoV-2 variants 2021-2022, when sharp increase morbidity observed with appearance Omicron variant. Real-time PCR methodology is available use majority scientific and diagnostic institutions Russia, which makes it possible coverage monitoring territories all 85 regions order accumulate information Central Services make epidemiological decisions. With developed by Research Institute Epidemiology Federal Service Surveillance on Consumer Rights Protection Human Wellbeing (FSSCRP Wellbeing) (CRIE), more than 6000 biological samples have been typed, 7% Delta variant 92% identified as 25 August 2022. Reagents 140,000 definitions supplied regional organizations.

Language: Английский

Citations

8
Tracking the evolution of the SARS-CoV-2 Delta variant of concern: analysis of genetic diversity and selection across the whole viral genome DOI Creative Commons
Katherine Li, Stephanie Melnychuk, Paul Sandstrom

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 8, 2023

Background Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has diversified extensively, producing five highly virulent lineages designated as variants of concern (VOCs). The Delta VOC emerged in India with increased transmission, immune evasion, and mortality, causing a massive global case surge 2021. This study aims to understand how the evolved by characterizing mutation patterns viral population before after its emergence. Furthermore, we aim identify influence positive negative selection on evolution prevalence different types genome. Methods Three groups whole genomes were retrieved from GISAID, sourced India, collection periods follows: Group A—during initial appearance SARS-CoV-2; B—just emergence variant; C—after establishment variant India. Mutations >1% each group identified BioEdit reveal differences quantity type. Sites under or FUBAR. results compared determine mutations correspond selective pressures profiles changed reflect genetic diversity Results number progressively Groups A–C, C reporting 2.2- 1.9-fold increase A B, respectively. Among all observed mutations, had highest percentage deletions (22.7%; vs. 4.2% 2.6% respectively), most altered final amino acid code, such non-synonymous substitutions deletions. Conversely, B synonymous that are effectively silent. sites experiencing but 2.4- 2.6 times more C, Conclusion Our findings demonstrated continuously during VOC. Despite this, reports heightened selection, which potentially preserves important gene regions evolution. contains an unprecedented positively selected sites, providing strong evidence active adaptation population.

Language: Английский

Citations

4
Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future DOI Creative Commons
Zhaomu Zeng, Xiuchao Geng, Xichao Wen

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 14, 2023

Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant pneumonia in December 2019, cumulative number infected people worldwide has exceeded 670 million, with over 6.8 million deaths. Despite marketing multiple series vaccines implementation strict prevention control measures many countries, spread prevalence SARS-CoV-2 have not been completely effectively controlled. The latest research shows that addition to angiotensin converting enzyme II (ACE2), dozens protein molecules, including AXL, can act as host receptors for infecting human cells, virus mutation immune evasion never seem stop. To sum up, this review summarizes organizes relevant literature, comprehensively reviews genome characteristics well receptor-based pathogenesis (including ACE2 other new receptors), evasion, vaccine development aspects, proposes a treatment opinions. It is expected provide theoretical basis an in-depth understanding pathogenic mechanism along ideas diagnosis classification, COVID-19-related disease drug development.

Language: Английский

Citations

4