Molecular Diversity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 24, 2024
Abstract
Pyroptosis,
as
a
lytic-inflammatory
type
of
programmed
cell
death,
has
garnered
considerable
attention
due
to
its
role
in
cancer
chemotherapy
and
many
inflammatory
diseases.
This
review
will
discuss
the
biochemical
classification
pyroptotic
inducers
according
their
chemical
structure,
mechanism,
these
targets.
A
structure-activity
relationship
study
on
is
revealed
based
surveyed
inducer
chemotherapeutics.
The
shared
features
structures
current
agents
were
displayed,
including
an
essential
cyclic
head,
vital
linker,
hydrophilic
tail
that
significant
for
π-π
interactions
hydrogen
bonding.
presented
structural
open
way
design
new
hybridized
classes
or
scaffolds
potent
future,
which
may
represent
solution
apoptotic-resistance
dilemma
along
with
synergistic
chemotherapeutic
advantage.
Graphical
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 247 - 247
Published: Feb. 8, 2025
N6-methyladenosine
(m6A)
is
the
most
prevalent
internal
chemical
modification
in
eukaryotic
messenger
RNA
(mRNA),
significantly
impacting
its
lifecycle
through
dynamic
and
reversible
processes
involving
methyltransferase,
demethylase,
binding
proteins.
These
regulate
mRNA
stability,
splicing,
nuclear
export,
translation,
degradation.
Programmed
cell
death
(PCD),
a
tightly
controlled
process
encompassing
apoptosis,
pyroptosis,
ferroptosis,
autophagy,
necroptosis,
plays
crucial
role
maintaining
cellular
homeostasis,
tissue
development,
function.
Recently,
m6A
has
emerged
as
significant
research
area
due
to
regulating
PCD
implications
cardiovascular
diseases
(CVDs).
In
this
review,
we
delve
into
intricate
relationship
between
various
types
modification,
emphasizing
their
pivotal
roles
initiation
progression
of
CVDs
such
myocardial
ischemia-reperfusion
(I/R),
atherosclerosis
(AS),
pulmonary
hypertension
(PH),
cardiomyopathy,
doxorubicin
(Dox)-induced
cardiotoxicity
(DIC),
heart
failure
(HF),
infarction
(MI).
Our
findings
underscore
potential
elucidating
CVD
pave
new
pathways
for
prevention
treatment
strategies.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(22), P. 16339 - 16339
Published: Nov. 15, 2023
Ferroptosis
is
a
newly
established
form
of
regulated
cell
death
characterized
by
intracellular
lipid
peroxidation
and
iron
accumulation
that
may
be
promising
cancer
treatment
strategy.
However,
the
function
therapeutic
value
ferroptosis
in
oral
squamous
carcinoma
(OSCC)
remain
inadequately
understood.
In
present
study,
we
investigated
biological
role
fat
mass
obesity-associated
gene
(FTO)
context
OSCC.
We
found
OSCC
had
greater
potential
for
ferroptosis,
FTO
associated
with
ferroptosis.
Furthermore,
higher
expression
sensitized
cells
to
vitro
vivo.
Mechanistically,
suppressed
anti-ferroptotic
factors,
acyl-CoA
synthetase
long-chain
family
member
3
(ACSL3)
glutathione
peroxidase
4
(GPX4),
demethylating
m6A
modification
on
mRNA
ACSL3
GPX4
decreasing
their
stability.
Taken
together,
our
findings
revealed
promotes
through
regulation.
Thus,
activation
high
levels
serve
as
target.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Oct. 19, 2023
Abstract
The
process
of
post-transcriptional
regulation
has
been
recognized
to
be
significantly
impacted
by
the
presence
N
6-methyladenosine
(m6A)
modification.
As
an
m6A
demethylase,
ALKBH5
shown
contribute
progression
different
cancers
increasing
expression
several
oncogenes.
Hence,
a
better
understanding
key
targets
in
cancer
cells
could
potentially
lead
development
new
therapeutic
targets.
However,
specific
role
pancreatic
neuroendocrine
neoplasms
(pNENs)
remains
largely
unknown.
Here,
we
demonstrated
that
was
up-regulated
pNENs
and
played
critical
tumor
growth
lipid
metabolism.
Mechanistically,
over-expression
found
increase
FABP5
m6A-
IGF2BP2
dependent
manner,
leading
disorders
Additionally,
activate
PI3K/Akt/mTOR
signaling
pathway,
resulting
enhanced
metabolism
proliferation
abilities.
In
conclusion,
our
study
uncovers
ALKBH5/IGF2BP2/FABP5/mTOR
axis
as
mechanism
for
aberrant
modification
highlights
molecular
basis
strategies
treatment.
Graphical
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(5), P. 514 - 514
Published: April 24, 2024
Musculoskeletal
diseases
(MSDs),
including
osteoarthritis
(OA),
osteosarcoma
(OS),
multiple
myeloma
(MM),
intervertebral
disc
degeneration
(IDD),
osteoporosis
(OP),
and
rheumatoid
arthritis
(RA),
present
noteworthy
obstacles
associated
with
pain,
disability,
impaired
quality
of
life
on
a
global
scale.
In
recent
years,
it
has
become
increasingly
apparent
that
N6-methyladenosine
(m6A)
is
key
regulator
in
the
expression
genes
multitude
biological
processes.
m6A
composed
0.1–0.4%
adenylate
residues,
especially
at
beginning
3′-UTR
near
translation
stop
codon.
The
can
be
classified
into
three
types,
namely
“writer”,
“reader”,
“eraser”.
Studies
have
shown
epigenetic
modulation
influences
mRNA
processing,
nuclear
export,
translation,
splicing.
Regulated
cell
death
(RCD)
autonomous
orderly
cells
under
genetic
control
to
maintain
stability
internal
environment.
Moreover,
distorted
RCDs
are
widely
used
influence
course
various
receiving
increasing
attention
from
researchers.
past
few
evidence
indicated
regulate
gene
thus
different
RCD
processes,
which
central
role
etiology
evolution
MSDs.
currently
confirmed
autophagy-dependent
death,
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
immunogenic
NETotic
oxeiptosis.
m6A–RCD
axis
inflammatory
response
chondrocytes
invasive
migratory
MM
bone
remodeling
capacity,
thereby
influencing
development
This
review
gives
complete
overview
regulatory
functions
across
muscle,
bone,
cartilage.
addition,
we
also
discuss
advances
by
m6A-targeted
factors
explore
clinical
application
prospects
therapies
targeting
MSD
prevention
treatment.
These
may
provide
new
ideas
directions
for
understanding
pathophysiological
mechanism
MSDs
treatment
these
diseases.
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(5), P. 1729 - 1743
Published: Jan. 1, 2024
Background:
N6-methyladenosine
(m
6
A)
is
the
most
common
and
abundant
mRNA
modification,
playing
an
essential
role
in
biological
processes
tumor
development.However,
of
m
A
methylation
skin
cutaneous
melanoma
(SKCM)
not
yet
clear.This
study
analyzed
expression
A-related
functional
genes
SKCM
aimed
to
explore
key
demethylase
ALKBH5
mediated
modification
its
potential
mechanism
human
SKCM.Methods:
Based
on
public
databases,
gene
landscape
was
portrayed.MeRIP-Seq
RNA-Seq
were
used
recognize
downstream
target
ALKBH5.In
vivo
vitro
phenotype
rescue
experiments
performed
ALKBH5-m
A-ABCA1
axis
SKCM.Results:
We
found
upregulated
SKCM,
associated
with
poor
prognosis.ALKBH5
can
promote
cell
proliferation,
colony
formation,
migration,
invasion
inhibit
autophagy
vitro,
facilitating
growth
metastasis
vivo.We
identified
ABCA1,
a
membrane
protein
that
assists
cholesterol
efflux,
as
ALKBH5-mediated
demethylation.Finally,
our
data
demonstrated
promoted
via
mediating
ABCA1
downregulation
by
reducing
stability
A-dependent
manner.Conclusion:
Our
findings
exhibited
value
progression
suggesting
therapeutic
SKCM.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Aug. 3, 2024
Abstract
The
resistance
of
cancer
cells
to
treatment
significantly
impedes
the
success
therapy,
leading
recurrence
various
types
cancers.
Understanding
specific
mechanisms
therapy
may
offer
novel
approaches
for
alleviating
drug
in
cancer.
Recent
research
has
shown
a
reciprocal
relationship
between
circular
RNAs
(circRNAs)
and
N6-methyladenosine
(m6A)
modification,
their
interaction
can
affect
sensitivity
therapy.
This
review
aims
summarize
latest
developments
m6A
modification
circRNAs
importance
regulating
Furthermore,
we
explore
mutual
exact
provide
insights
into
potential
future
reversing
resistance.
