Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 2, 2023
Abstract
Objective
Hepatocellular
carcinoma
(HCC)
is
an
extremely
deadly
cancer
with
few
effective
therapeutic
options
available.
Ceramide
synthases
(CERS),
a
family
of
enzymes
that
regulate
sphingolipid
metabolism,
have
been
suggested
to
play
role
in
initiation
and
progression.
Whereas
the
specific
functions
CERS
HCC
pathogenesis
not
yet
fully
elucidated.
Methods
The
TCGA
ICGC
databases
were
employed
analyze
expression
levels
clinical
relevance
genes
HCC.
Functional
enrichment
analyses
performed
identify
pathways
associated
CERS5.
correlation
between
CERS5
tumor
immune
microenvironment
was
investigated.
mutation
landscape
immunotherapy
efficacy
evaluated.
experiments
vitro
conducted
assess
CERS5’s
impact
on
cell
proliferation
invasion.
Results
Aberrant
detected
only
but
also
other
cancers,
has
linked
both
overall
survival
disease-free
survival.
Among
members,
identified
as
prognosis-related
gene,
up-regulated
validated
database
tissue
samples.
Higher
poorer
prognosis
well
advanced
pathologic
stage
grade,
confirmed
by
databases.
Besides,
prognostic
nomogram
combining
stage,
status,
established
further
validated,
which
favorable
value
for
prediction.
showed
overexpression
resulted
enriched
carcinogenesis,
drug
PI3K/AKT/mTOR
signaling
pathway,
immune-related
pathways.
In
addition,
correlated
positively
immunogenic
death
modulators
checkpoints,
infiltration,
response,
featured
immunologically
“hot”
environment
microenvironment.
Finally,
functional
knockdown
shown
inhibit
growth
invasion
hepatocellular
carcinoma,
potentially
through
targeting
pathway.
Conclusions
Based
our
findings,
appears
great
potential
precise
biomarker
novel
target
Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
16(3), P. 943 - 951
Published: Dec. 31, 2024
Background:
Rechallenge
with
immune
checkpoint
inhibitors
(ICI)
shows
promise
in
various
cancers,
but
data
esophageal
squamous
cell
carcinoma
(ESCC)
is
limited.This
study
aimed
to
evaluate
the
efficiency
and
safety
of
ICI
rechallenge
ESCC.Materials
Methods:
This
multicenter
analyzed
ESCC
patients
rechallenged
from
January
2020
March
2023
across
two
medical
institutions.Patients
were
divided
into
(R)
non-rechallenge
(NR)
groups.Key
outcomes
studied
progression-free
survival
(PFS),
overall
(OS),
safety.Results:
Among
329
included
patients,
211
R
group
118
NR
group,
a
median
follow-up
17.1
months.The
exhibited
significantly
prolonged
PFS
(4.7
vs.
3.2
months;
p
<.001)
OS
(9.3
6.2
compared
group.Notably,
for
who
initially
received
radiotherapy,
showed
longer
mPFS
(5.1
mOS
(10.4
5.9
<.001).Incidences
all-grade
(64.5%
66.1%;p
=
.764)and
grade
≥3
adverse
events
(17.5%
18.6%;
.802)did
not
differ
between
groups.Conclusion:
demonstrates
efficacy
manageable
ESCC,
particularly
post-radiotherapy.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(8), P. 1119 - 1119
Published: Aug. 9, 2023
Manipulating
the
immune
system
by
blocking
checkpoint
receptors
is
basis
of
immunotherapy,
a
relevant
tool
in
current
clinical
oncology.
The
strategy
checkpoints
(Immune
Checkpoint
Inhibitors,
ICI)
consists
using
monoclonal
antibodies
to
inhibit
interaction
between
ligand
and
inhibitory
from
triggering
complete
activation
helper
cytotoxic
T
cells
fight
against
tumour
cells.
Immunotherapy
has
benefited
patients
with
diverse
cancers
such
as
stomach,
lung,
melanoma,
head
neck
squamous
cell
carcinoma,
among
others.
Unfortunately,
growing
number
reports
have
indicated
that
ICI
treatment
also
can
show
dark
side
under
specific
conditions;
some
adverse
effects
induced
are
immunosuppression,
opportunistic
infections,
organ-specific
alterations.
This
review
discusses
immunologic
aspects
related
these
unwanted
effects.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 14, 2023
Abstract
Objective
Hepatocellular
carcinoma
(HCC)
is
an
extremely
deadly
cancer
with
few
effective
therapeutic
options
available.
Ceramide
synthases
(CERS),
a
family
of
enzymes
that
regulate
sphingolipid
metabolism,
have
been
suggested
to
play
role
in
initiation
and
progression.
Whereas
the
specific
functions
CERS
HCC
pathogenesis
not
yet
fully
elucidated.
Methods
The
TCGA
ICGC
databases
were
employed
analyze
expression
levels
clinical
relevance
genes
HCC.
Functional
enrichment
analyses
performed
identify
pathways
associated
CERS5.
correlation
between
CERS5
tumor
immune
microenvironment
was
investigated.
mutation
landscape
immunotherapy
efficacy
evaluated.
experiments
vitro
conducted
assess
CERS5’s
impact
on
cell
proliferation
invasion.
Results
Aberrant
detected
only
but
also
other
cancers,
has
linked
both
overall
survival
disease-free
survival.
Among
members,
identified
as
prognosis-related
gene,
up-regulated
validated
database
tissue
samples.
Higher
poorer
prognosis
well
advanced
pathologic
stage
grade,
confirmed
by
databases.
Besides,
prognostic
nomogram
combining
stage,
status,
established
further
validated,
which
favorable
value
for
prediction.
showed
overexpression
resulted
enriched
carcinogenesis,
drug
PI3K/AKT/mTOR
signaling
pathway,
immune-related
pathways.
In
addition,
correlated
positively
immunogenic
death
modulators
checkpoints,
infiltration,
response,
featured
immunologically
“hot”
environment
microenvironment.
Finally,
functional
knockdown
shown
inhibit
growth
invasion
hepatocellular
carcinoma,
potentially
through
targeting
pathway.
Conclusions
Based
our
findings,
appears
great
potential
precise
biomarker
novel
target
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 2, 2023
Abstract
Objective
Hepatocellular
carcinoma
(HCC)
is
an
extremely
deadly
cancer
with
few
effective
therapeutic
options
available.
Ceramide
synthases
(CERS),
a
family
of
enzymes
that
regulate
sphingolipid
metabolism,
have
been
suggested
to
play
role
in
initiation
and
progression.
Whereas
the
specific
functions
CERS
HCC
pathogenesis
not
yet
fully
elucidated.
Methods
The
TCGA
ICGC
databases
were
employed
analyze
expression
levels
clinical
relevance
genes
HCC.
Functional
enrichment
analyses
performed
identify
pathways
associated
CERS5.
correlation
between
CERS5
tumor
immune
microenvironment
was
investigated.
mutation
landscape
immunotherapy
efficacy
evaluated.
experiments
vitro
conducted
assess
CERS5’s
impact
on
cell
proliferation
invasion.
Results
Aberrant
detected
only
but
also
other
cancers,
has
linked
both
overall
survival
disease-free
survival.
Among
members,
identified
as
prognosis-related
gene,
up-regulated
validated
database
tissue
samples.
Higher
poorer
prognosis
well
advanced
pathologic
stage
grade,
confirmed
by
databases.
Besides,
prognostic
nomogram
combining
stage,
status,
established
further
validated,
which
favorable
value
for
prediction.
showed
overexpression
resulted
enriched
carcinogenesis,
drug
PI3K/AKT/mTOR
signaling
pathway,
immune-related
pathways.
In
addition,
correlated
positively
immunogenic
death
modulators
checkpoints,
infiltration,
response,
featured
immunologically
“hot”
environment
microenvironment.
Finally,
functional
knockdown
shown
inhibit
growth
invasion
hepatocellular
carcinoma,
potentially
through
targeting
pathway.
Conclusions
Based
our
findings,
appears
great
potential
precise
biomarker
novel
target
