Abstract
Mitochondria-associated
membranes
(MAMs)
are
tethering
regions
amid
the
of
endoplasmic
reticulum
(ER)
and
mitochondria.
They
a
lipid
raft-like
structure
occupied
by
various
proteins
that
facilitates
signal
transduction
between
two
organelles.
The
MAM
proteome
participates
in
cellular
functions
such
as
calcium
(Ca
2+
)
homeostasis,
synthesis,
ER
stress,
inflammation,
autophagy,
mitophagy,
apoptosis.
human
kinome
is
superfamily
homologous
consisting
538
kinases.
MAM-associated
kinases
participate
aforementioned
act
cell
fate
executors.
Studies
have
proved
dysregulated
kinase
interactions
an
etiology
for
diseases
including
cancer,
diabetes
mellitus,
neurodegenerative
diseases,
cardiovascular
(CVDs),
obesity.
Several
small
inhibitory
molecules
been
well
explored
promising
drug
candidates
clinical
trials
with
accelerating
impact
field
precision
medicine.
This
review
narrates
physiological
actions,
pathophysiology,
therapeutic
potential
recent
updates
field.
Graphical
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 31, 2025
Abstract
Spinal
cord
injury
(SCI)
is
one
of
the
most
devastating
and
catastrophic
types
injury,
with
high
rates
mortality
disability.
Ferroptosis
has
become
target
many
major
incurable
human
diseases.
By
inhibiting
ferroptosis,
melatonin
(MT)
can
reduce
damage
in
various
organs,
but
protective
effect
MT
on
SCI
not
been
reported
yet.
The
modified
Ellen's
method
was
used
to
establish
an
rat
model.
spinal
neurons
recovery
motor
function
were
observed.
In
vitro
experiments,
oxygen-glucose
deprivation/reoxygenation
(OGD/R)
model
established
by
using
mouse
hippocampal
neuron
(HT22)
cells
simulate
ischemia-reperfusion
injury.
A
ferroptosis
directly
induced
Erastin
also
used.
nuclear
factor
erythroid
2-related
2
(Nrf2)
inhibitor
ML
385
further
detect
mechanism
through
which
inhibits
protects
neuronal
cells.
Our
study
demonstrates
that
rats,
promote
behavior
injured
tissue
after
SCI.
Under
electron
microscope,
inhibited
rescued
damaged
mitochondria,
partially
restored
mitochondrial
structure.
ML385,
Nrf2
inhibitor,
reversed
effects
MT.
Overall,
may
alleviate
early
activating
Nrf2/heme
oxygenase-1(HO-1)/glutathione
peroxidase
4
(GPX
4)
pathway.
