Cited by A sodium alginate-based injectable hydrogel system for locoregional treatment of colorectal cancer by eliciting pyroptosis and apoptosis

Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity DOI

Ziyu Guo,

Yihuang Liu,

Danyao Chen

et al.

Journal of Translational Internal Medicine, Journal Year: 2025, Volume and Issue: 13(1), P. 10 - 32

Published: Feb. 1, 2025

In the evolving landscape of cancer treatment, strategic manipulation regulated cell death (RCD) pathways has emerged as a crucial component effective anti-tumor immunity. Evidence suggests that tumor cells undergoing RCD can modify immunogenicity microenvironment (TME), potentially enhancing its ability to suppress progression and metastasis. this review, we first explore mechanisms apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, along with crosstalk between these modalities. We then discuss how processes activate antigen-presenting cells, facilitate cross-priming CD8+ T trigger immune responses, highlighting complex effects novel forms on TME biology. Furthermore, summarize potential drugs nanoparticles induce or inhibit emerging their therapeutic roles in treatment. Finally, put forward existing challenges future prospects for targeting anti-cancer Overall, review enhances our understanding molecular biological impacts RCD-based therapies, providing new perspectives strategies

Language: Английский

Citations

Harnessing Pyroptosis for Lung Cancer Therapy: The Impact of NLRP3 Inflammasome Activation DOI

Rajiv Dahiya, Vijaykumar Sutariya, Sheeba Varghese Gupta

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155444 - 155444

Published: Aug. 1, 2024

Language: Английский

Citations

IFN-γ Approaches in Tumor Suppression, Its Challenges, and Future Directions: A Review of Recent Advances DOI

Mohammad Reza Ataherian,

Nasim Hafezi, Elaheh Ferdosi-Shahandashti

et al.

Journal of Interferon & Cytokine Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

IFN-γ is recognized as an immunoregulatory cytokine due to its dual role in both accelerating and dampening immunological responses. Accordingly, the context of tumor immunotherapy, therapeutic outcome contingent upon factors such dosage expression status downstream signaling molecules. Furthermore, coadministration with various immunestimulatory agents, including anticheckpoint inhibitors, chemotherapeutic herbal-based medicines, may potentially overcome IFN-γ-related challenges enhance response rate. We decipher mechanisms cell eradication facilitated by IFN-γ, last achievements IFN-γ-mediated immunotherapy across cancers, strategies address failure IFN-γ-based immunotherapy. Unraveling molecular that lead antitumor actions could assist pinpointing agents target immune-modulatory features thereby increasing

Language: Английский

Citations

Cyclometalated iridium(III)-lonidamine conjugates: Mitochondrial targeting and pyroptosis induction DOI

Xing-Yun Lu,

Lin-Yuan Zhu,

Zhu Hou

et al.

Journal of Inorganic Biochemistry, Journal Year: 2025, Volume and Issue: 266, P. 112852 - 112852

Published: Feb. 9, 2025

Language: Английский

Citations

An epigenetic regulator synergizes with alphavirus-mediated gene therapy via biomimetic delivery for enhanced cancer therapy DOI

Yuqiong Xia,

Maozhi Su,

Zixuan Ye

et al.

Trends in biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

Communication Disruption in the Immune System DOI

Robert Barouki,

Xavier Coumoul, Étienne Blanc

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge? DOI

Jintao Fang,

Weihan Zhu,

Dian Yu

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 3349 - 3360

Published: March 1, 2025

Pyroptosis is a unique form of programmed cell death characterized by intense inflammation. It involves the activation Gasdermin proteins, which membrane pores, leading to rapid rupture and release inflammatory molecules. Unlike other types death, pyroptosis has distinct mechanisms plays complex role in chronic intestinal diseases, including bowel disease, fibrosis, infectious enteritis, colorectal cancer. This review comprehensively examines how influences disease development progression while exploring therapeutic potential targeting pyroptosis-related pathways. Moreover, interplay between gut microbiota summarized, highlighting its critical pathogenesis disorders. A deeper understanding these diseases may provide valuable insights for future research contribute innovative strategies gastroenterology.

Language: Английский

Citations

PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation DOI

Xiao Fu, Guoqing Zhang, Zhichao Hou

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: March 11, 2025

Abstract Background Myeloid-derived suppressor cells (MDSCs) in tumor microenvironment reduce the efficacy of immunotherapy. PKN2 plays a role colon cancer, but its function esophageal cancer (EC) remains unclear. This study investigated expression MDSCs derived from EC tissues and determined whether regulates immunosuppressive activity by mediating fatty acid oxidation (FAO). Materials methods was GEO database, patients, 4-NQO-induced mice, as well different types immune cells. The effect on polymorphonuclear myeloid-derived (PMN-MDSCs) co-culture PMN-MDSCs CD4 + /CD8 T patient-derived organoids autologous performed to observe PMN-MDSCs. Results is highly expressed compared normal tissues, especially tumor-infiltrated Overexpressing contributes vitro. PKN2-overexpressing inhibited killing ability cytotoxic lymphocytes promoted organoid growth. promotes FAO via CPT1B (a key enzyme FAO). Mechanistically, transcription upregulating STAT3 phosphorylation. Conclusions increased human mouse tissues. enhancing facilitating phosphorylation transcription, which turn leads CPT1B-mediated Targeted inhibition expected improve immunotherapeutic patients.

Language: Английский

Citations

Ferroptosis, necroptosis, and pyroptosis in calcium oxalate crystal-induced kidney injury DOI

Kun Tang, Tao Ye,

Yu He

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167791 - 167791

Published: March 1, 2025

Kidney stones represent a highly prevalent urological disorder worldwide, with high incidence and recurrence rates. Calcium oxalate (CaOx) crystal-induced kidney injury serves as the foundational mechanism for formation progression of CaOx stones. Regulated cell death (RCD) such ferroptosis, necroptosis, pyroptosis are essential in pathophysiological process injury. Ferroptosis, newly discovered RCD, is characterized by its reliance on iron-mediated lipid peroxidation. Necroptosis, widely studied programmed necrosis, initiates necrotic phenotype that resembles apoptosis appearance. Pyroptosis, type RCD involves gasdermin protein, accompanied inflammation immune response. In recent years, increasing amounts evidence has demonstrated significant processes involved Herein, we summed up roles Furthermore, delved into curative potential targeting

Language: Английский

Citations

5-FU@HFn combined with decitabine induces pyroptosis and enhances antitumor immunotherapy for chronic myeloid leukemia DOI

Zuowei Yuan,

Guoyun Jiang,

Ying Yuan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 28, 2025

Tyrosine kinase inhibitors (TKIs) constitute the primary treatment for chronic myeloid leukemia (CML). However, resistance to TKIs often leads failure. Pyroptosis, a form of programmed cell death, has emerged as promising strategy in cancer therapy due its ability eliminate tumor cells while stimulating antitumor immunity. Low-dose decitabine (DAC) been shown reverse methylation-induced silencing pyroptosis-related gene gasdermin E (GSDME) some cells, offering potential new therapeutic option CML. Herein, we propose combination using 5-fluorouracil (5-FU), broad-spectrum chemotherapeutic agent, and low-dose DAC induce pyroptosis CML via caspase-3/GSDME pathway. nonspecific targeting 5-FU diminishes efficacy causes off-target toxicity, highlighting need targeted drug delivery system. In this study, developed 5-FU@HFn nanoparticles (NPs) by loading into recombinant human heavy chain ferritin (HFn) nanocage through high-temperature channels on protein cage. The efficiency was approximately 50.62 ± 1.17 µg per mg HFn. NPs selectively CD71-mediated uptake, significantly enhancing effects 5-FU. When combined with DAC, effectively activated pathway both TKI-sensitive TKI-resistant cells. mouse model, suppressed tumorigenesis triggered robust immune response, facilitating clearance leukemic Furthermore, exhibited excellent vivo safety. innovative strategy, combining induces caspase-3/GSDME-mediated activates immunity This approach offers alternative patients resistant or intolerant TKIs.

Language: Английский

Citations