Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol DOI Creative Commons
Yanbei Tu,

Dai Gui-yu,

Yanyan Chen

et al.

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses challenge in transitioning CEL from traditional remedy to modern pharmaceutical agent. Recently, emerging discovery approaches products have broadened extensive avenues for uncovering comprehensive and promoting its drug development. Herein, diverse strategies are overviewed pharmacological toxicological studies CEL, including chemical proteomics, protein microarray, degradation‐based profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based screening, multi‐omics analysis, hypothesis‐driven confirmation. Dozens targets been identified, which significantly suggests that functions as multi‐target Further interaction analysis frequency collected reveal PRDXs, HMGB1, HSP90, STAT3, PKM2 may serve key CEL. Additionally, this review highlights positive role facilitating CEL‐based combination therapy delivery, essential further advancing clinical applications Efforts identification not only aid unraveling scientific underpinnings multiple effects but also offer crucial insights development drugs.

Language: Английский

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol DOI Creative Commons
Yanbei Tu,

Dai Gui-yu,

Yanyan Chen

et al.

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses challenge in transitioning CEL from traditional remedy to modern pharmaceutical agent. Recently, emerging discovery approaches products have broadened extensive avenues for uncovering comprehensive and promoting its drug development. Herein, diverse strategies are overviewed pharmacological toxicological studies CEL, including chemical proteomics, protein microarray, degradation‐based profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based screening, multi‐omics analysis, hypothesis‐driven confirmation. Dozens targets been identified, which significantly suggests that functions as multi‐target Further interaction analysis frequency collected reveal PRDXs, HMGB1, HSP90, STAT3, PKM2 may serve key CEL. Additionally, this review highlights positive role facilitating CEL‐based combination therapy delivery, essential further advancing clinical applications Efforts identification not only aid unraveling scientific underpinnings multiple effects but also offer crucial insights development drugs.

Language: Английский

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