Exosomes derived from cardiac fibroblasts with Ang-II stimulation provoke myocardial hypertrophy via miR-15b-5p/PTEN-L axis DOI
Zhiwen Hu, Dongjie Xiao, Liang Wang

et al.

Experimental Cell Research, Journal Year: 2024, Volume and Issue: unknown, P. 114380 - 114380

Published: Dec. 1, 2024

Language: Английский

Compound K promotes thermogenic signature and mitochondrial biogenesis via the UCP1-SIRT3-PGC1α signaling pathway DOI Open Access
Jung-Mi Oh,

G.-W. Kim,

Jae Kyo Jeong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117838 - 117838

Published: Jan. 11, 2025

Language: Английский

Citations

0
Mitochondria-dependent apoptosis was involved in the alleviation of Jujuboside A on diabetic kidney disease-associated renal tubular injury via YY1/PGC-1α signaling DOI
Tingting Yang, Yuting Peng, Yuting Shao

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156411 - 156411

Published: Jan. 21, 2025

Language: Английский

Citations

0
MITOCDNB DECREASES PLATELET ACTIVATION THROUGH ITS SELECTIVE ACTION ON MITOCHONDRIAL THIOREDOXIN REDUCTASE DOI Open Access
Diego Méndez, Francisca Tellería, Marcelo Alarcón

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117840 - 117840

Published: Jan. 21, 2025

Language: Английский

Citations

0
WIPI1-mediated mitophagy dysfunction in ventricular remodeling associated with long-term diabetes mellitus DOI

Daiqi Liu,

Lu Zhou,

Beizheng Xu

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 130, P. 111663 - 111663

Published: Feb. 15, 2025

Language: Английский

Citations

0
NOX4 mediates the renoprotection of remote ischemic preconditioning against acute kidney injury by inhibiting NF-κB signaling and tubular apoptosis DOI
Wei Wei,

Letian Yang,

Yuyi Zhu

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 129, P. 111662 - 111662

Published: Feb. 16, 2025

Language: Английский

Citations

0
Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies DOI Creative Commons
Chen Chen, Guo-Hua Dai, Maoxia Fan

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Myocardial ischemia has the highest disease burden among all cardiovascular diseases making it a significant challenge to global public health. It can result in myocardial cell damage and death due impaired mitochondrial endoplasmic reticulum (ER) functions. These two organelles are important regulators of death. In recent years, research shifted from isolated studies individual more integrative approach, with particular focus on their membrane contact sites-Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs). dynamic microdomains play crucial role regulating material exchange signal transduction between mitochondria. This review comprehensively describes intricate structure MAMs multifaceted roles cellular pathophysiological processes. Particular was directed at far-reaching effects key pathological events including calcium homeostasis, dysfunction, ER stress, oxidative autophagy ischemic heart (IHD). The potential treatment targets regulatory mechanisms were discussed summarized, providing novel directions approaches for improving ischemia-related diseases.

Language: Английский

Citations

0
Spermine alleviates myocardial cell aging by inhibiting mitochondrial oxidative stress damage DOI

Jing Yang,

Chunrui Zhang, Zixuan Li

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177477 - 177477

Published: March 1, 2025

Language: Английский

Citations

0
Rhein alleviates diabetic cardiomyopathy by inhibiting mitochondrial dynamics disorder, apoptosis and hypertrophy in cardiomyocytes DOI

Hejuan Li,

Genwang Wang,

Yi Tang

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111734 - 111734

Published: March 1, 2025

Language: Английский

Citations

0
Flavonoids in the regulation of microglial-mediated neuroinflammation; focus on fisetin, rutin, and quercetin DOI

Mohannad Hamid Jasim,

Rosull Saadoon Abbood,

Gaurav Sanghvi

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114537 - 114537

Published: March 1, 2025

Language: Английский

Citations

0
MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review DOI Creative Commons

Avinash Mohan,

Priti Talwar

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: March 28, 2025

Abstract Mitochondria-associated membranes (MAMs) are tethering regions amid the of endoplasmic reticulum (ER) and mitochondria. They a lipid raft-like structure occupied by various proteins that facilitates signal transduction between two organelles. The MAM proteome participates in cellular functions such as calcium (Ca 2+ ) homeostasis, synthesis, ER stress, inflammation, autophagy, mitophagy, apoptosis. human kinome is superfamily homologous consisting 538 kinases. MAM-associated kinases participate aforementioned act cell fate executors. Studies have proved dysregulated kinase interactions an etiology for diseases including cancer, diabetes mellitus, neurodegenerative diseases, cardiovascular (CVDs), obesity. Several small inhibitory molecules been well explored promising drug candidates clinical trials with accelerating impact field precision medicine. This review narrates physiological actions, pathophysiology, therapeutic potential recent updates field. Graphical

Language: Английский

Citations

0