Mitochondria for Cardiovascular Therapy: A Deep Dive into Drug Targets and Therapeutic Approaches

Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 4, 2025

Language: Английский

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Dipeptidyl Peptidase 3 Induces Myocardial Ischemia-Reperfusion Injury by Mediating Mitophagy and the Intrinsic Apoptotic Pathway

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177592 - 177592

Published: April 1, 2025

Language: Английский

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Hyperoside suppresses NSCLC progression by inducing ATG13-mediated autophagy and apoptosis

Cellular Immunology, Journal Year: 2025, Volume and Issue: 411-412, P. 104947 - 104947

Published: April 6, 2025

Language: Английский

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Leptin attenuates diabetic cardiomyopathy-induced cardiac remodeling via regulating cGAS/STING signaling and Opa1-mediated mitochondrial fusion

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111805 - 111805

Published: April 1, 2025

Language: Английский

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Effects of Dietary Fiber and Acetate on Alcoholic Heart Disease and Intestinal Microbes in Mice

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

ABSTRACT Alcoholic heart disease (AHD) is a severe cardiovascular condition linked to chronic alcohol consumption. This study investigates the effects of high‐fiber diet and acetate on gut microbiota cardiac function in AHD mouse models. Sixty male C57BL/6 mice were divided into six groups, receiving either control diet, or supplementation alongside treatment. Results revealed that fibrosis failure notably improved diets. Transcriptomic analyses indicated dietary interventions modulated expression genes involved lipid metabolism TGF‐β signaling pathway. Additionally, 16S rRNA sequencing showed altered composition, enhancing abundance beneficial bacteria such as Akkermansia muciniphila , Lactobacillus intestinalis Bacteroides acidifaciens . These microbes exhibited positive correlations with related fat signaling, suggesting potential mechanism for microbiota's role pathology. ROC analysis identified these promising biomarkers detection. Overall, our findings underscore therapeutic fiber modulating improving AHD, highlighting intricate relationship between health management.

Language: Английский

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Mechanisms and Therapeutic Potential of Multiple Forms of Cell Death in Myocardial Ischemia–Reperfusion Injury

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13492 - 13492

Published: Dec. 17, 2024

Programmed cell death, especially programmed necrosis such as necroptosis, ferroptosis, and pyroptosis, has attracted significant attention recently. Traditionally, was thought to occur accidentally without signaling pathways, but recent discoveries have revealed that molecular pathways regulate certain forms of necrosis, similar apoptosis. Accumulating evidence indicates is involved in the development various diseases, including myocardial ischemia-reperfusion injury (MIRI). MIRI occurs when blood flow oxygen return an ischemic area, causing excessive production reactive species. While this reperfusion critical for treating infarction, it inevitably causes cellular damage via oxidative stress. Furthermore, triggers multiple cardiomyocyte which primary cause inflammation, cardiac tissue remodeling, ensuing heart failure. Therefore, understanding mechanisms death crucial therapeutic target discovery. Developing strategies inhibit simultaneously could provide effective protection against MIRI. In paper, we review fundamental MIRI-specific apoptosis, pyroptosis. Additionally, suggest simultaneous suppression be therapy identify potential targets implementing strategy.

Language: Английский

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Exosomes derived from cardiac fibroblasts with Ang-II stimulation provoke myocardial hypertrophy via miR-15b-5p/PTEN-L axis

Experimental Cell Research, Journal Year: 2024, Volume and Issue: unknown, P. 114380 - 114380

Published: Dec. 1, 2024

Language: Английский

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