ABSTRACT
Alcoholic
heart
disease
(AHD)
is
a
severe
cardiovascular
condition
linked
to
chronic
alcohol
consumption.
This
study
investigates
the
effects
of
high‐fiber
diet
and
acetate
on
gut
microbiota
cardiac
function
in
AHD
mouse
models.
Sixty
male
C57BL/6
mice
were
divided
into
six
groups,
receiving
either
control
diet,
or
supplementation
alongside
treatment.
Results
revealed
that
fibrosis
failure
notably
improved
diets.
Transcriptomic
analyses
indicated
dietary
interventions
modulated
expression
genes
involved
lipid
metabolism
TGF‐β
signaling
pathway.
Additionally,
16S
rRNA
sequencing
showed
altered
composition,
enhancing
abundance
beneficial
bacteria
such
as
Akkermansia
muciniphila
,
Lactobacillus
intestinalis
Bacteroides
acidifaciens
.
These
microbes
exhibited
positive
correlations
with
related
fat
signaling,
suggesting
potential
mechanism
for
microbiota's
role
pathology.
ROC
analysis
identified
these
promising
biomarkers
detection.
Overall,
our
findings
underscore
therapeutic
fiber
modulating
improving
AHD,
highlighting
intricate
relationship
between
health
management.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Feb. 26, 2025
Lung
cancer
remains
a
major
global
health
challenge
and
one
of
the
leading
causes
cancer-related
deaths
worldwide.
Despite
significant
advancements
in
treatment,
challenges
such
as
drug
resistance,
side
effects,
metastasis
recurrence
continue
to
impact
patient
outcomes
quality
life.
In
response,
there
is
growing
interest
complementary
integrative
approaches
care.
Traditional
Chinese
medicine
(TCM),
with
its
long
history,
abundant
clinical
experience,
holistic
perspective
individualized
approach,
has
garnered
increasing
attention
for
role
lung
prevention
management.
This
review
provides
comprehensive
overview
advances
TCM
covering
theoretical
foundation,
treatment
principles,
experiences
evidence
supporting
efficacy.
We
also
provide
systematic
summary
preclinical
mechanisms,
through
which
impacts
cancer,
including
induction
cell
death,
reversal
inhibition
modulation
immune
responses.
Additionally,
future
prospects
are
discussed,
offering
insights
into
expanded
application
integration
modern
address
this
challenging
disease.
International Journal of Medical Sciences,
Journal Year:
2025,
Volume and Issue:
22(7), P. 1640 - 1657
Published: Feb. 28, 2025
Doxorubicin-induced
myocardial
injury,
characterized
by
hypertrophy
and
heart
failure
(HF),
represents
a
primary
contributor
to
end-stage
cardiovascular
mortality
associated
with
anthracycline
drugs.
Prior
research
has
elucidated
that
SIRT6-mediated
oxidative
processes
mitochondrial
metabolic
reprogramming
are
pivotal
in
sustaining
energy
metabolism
during
damage
cardiomyocytes.
In
the
aftermath
of
doxorubicin-induced
fibrosis
exacerbate
impairment
cardiac
ejection
function,
resulting
elevated
oxygen
consumption.
This
condition
is
accompanied
disrupted
ATP
production,
diminished
biogenesis,
inadequate
synthesis
new
DNA,
collectively
triggering
necroptosis
apoptosis
pathways.
Our
preliminary
experimental
results
have
confirmed
SIRT6,
traditional
medicine,
exerts
cardioprotective
effects.
Nevertheless,
interaction
between
SIRT6
Nrf-2-mediated
biogenesis
context
HF
remains
inadequately
understood.
The
generation
mitochondria
key
mechanism
involved
DNA
repair
cell
cycle
management.
Abstract
Mitochondria-associated
membranes
(MAMs)
are
tethering
regions
amid
the
of
endoplasmic
reticulum
(ER)
and
mitochondria.
They
a
lipid
raft-like
structure
occupied
by
various
proteins
that
facilitates
signal
transduction
between
two
organelles.
The
MAM
proteome
participates
in
cellular
functions
such
as
calcium
(Ca
2+
)
homeostasis,
synthesis,
ER
stress,
inflammation,
autophagy,
mitophagy,
apoptosis.
human
kinome
is
superfamily
homologous
consisting
538
kinases.
MAM-associated
kinases
participate
aforementioned
act
cell
fate
executors.
Studies
have
proved
dysregulated
kinase
interactions
an
etiology
for
diseases
including
cancer,
diabetes
mellitus,
neurodegenerative
diseases,
cardiovascular
(CVDs),
obesity.
Several
small
inhibitory
molecules
been
well
explored
promising
drug
candidates
clinical
trials
with
accelerating
impact
field
precision
medicine.
This
review
narrates
physiological
actions,
pathophysiology,
therapeutic
potential
recent
updates
field.
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