Unraveling the advances of non-coding RNAs on the tumor microenvironment: innovative strategies for cancer therapies DOI Creative Commons
Di Mu, Bing Han, Yi Luo

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: June 2, 2025

Non-coding RNAs (ncRNAs) are crucial molecules that do not encode proteins but play roles in regulating various biological processes. Recent research highlights ncRNAs only control gene expression within cells also facilitate intercellular communication via exosomes and other carriers. This function is vital the tumor microenvironment (TME). Our review covers structure functions of different ncRNAs, such as microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs). We examine how these influence initiation progression. Additionally, we explore their role promoting growth or immune evasion by modulating TME. The potential using therapeutic targets biomarkers for clinical use discussed. As our understanding grows, development new therapies based on anticipated to offer improved treatment options cancer patients.

Language: Английский

Tumor-derived exosomes: unravelling the pathogenesis of pancreatic cancer with liver metastases and exploring the potential for clinical translation DOI
Dongqi Li, Xiangyu Chu, Yongsu Ma

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 611, P. 217403 - 217403

Published: Dec. 19, 2024

Language: Английский

Citations

3
The role of macrophages in liver metastasis: mechanisms and therapeutic prospects DOI Creative Commons
Qin Yuan,

Linlin Jia,

Jiahua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Metastasis is a hallmark of advanced cancer, and the liver common site for secondary metastasis many tumor cells, including colorectal, pancreatic, gastric, prostate cancers. Macrophages in microenvironment (TME) promote cell through various mechanisms, angiogenesis immunosuppression, play unique role development metastasis. are affected by variety factors. Under conditions hypoxia increased acidity TME, more factors now found to polarization macrophages M2 type, exosomes amino acids. M2-type secretion such as VEGF, IL-1β, TGF-β1. subjected multiple regulatory mechanisms. They also interact with cells within co-regulate certain conditions, creation an immunosuppressive microenvironment. This interaction promotes metastasis, drug resistance, immune escape. Based on advent single-cell sequencing technology, further insights into macrophage subpopulations may help exploring new therapeutic targets future. In this paper, we will focus how affect well other each other, investigate mechanisms involved their potential targets.

Language: Английский

Citations

0
Multiple roles of mitochondria in tumorigenesis and treatment: from mechanistic insights to emerging therapeutic strategies DOI Creative Commons
Min Zhang, Yuchen Yang, Jiacheng Wu

et al.

ONCOLOGIE, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

0
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-AKT signaling and glycolysis DOI

Xiaoyu Tu,

Wanfu Lin,

Xiaofeng Zhai

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156750 - 156750

Published: April 1, 2025

Language: Английский

Citations

0
microRNA-4488 is differentially regulated during dengue virus infection and clearance of the virus DOI Creative Commons
Roxana Filip, Parrish Evers,

Spencer M. Uguccioni

et al.

Frontiers in RNA Research, Journal Year: 2025, Volume and Issue: 3

Published: April 16, 2025

Dengue virus (DENV) is a zoonotic disease transmitted to humans via mosquito bites. Viral infection systemic in and can lead organ failure including the liver. Since there are many molecular changes that precede liver failure, identification of progress at level informative. As an RNA virus, DENV perturbs non-coding RNAs microRNAs. Here we examine microRNA profiles hepatoma cells using small molecule–mediated annotation miRNA targets. It was previously shown treatment with broadly antiviral oxysterol 25-hydroxycholesterol (25HC) induces expression microRNAs Herein, show 25HC potently against identify miR-4488 as which overexpressed during downregulated treatment. We also when viral levels lowered siRNA, suggesting this involved host-response infection. closely correlate liver, it serves biomarker for may contribute overall effects organ.

Language: Английский

Citations

0
A review of the role of tumor-derived exosomes in cancers treatment and progression DOI

Wajida Ataallah Khidr,

Karar H. Alfarttoosi,

Waam Mohammed Taher

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 157, P. 114782 - 114782

Published: May 6, 2025

Language: Английский

Citations

0
Progress of exosomes in regulating tumor metastasis by remodeling the pre-metastatic immune microenvironment DOI

Jiangning Xiang,

Yao Lin,

Shan Wang

et al.

Cellular Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 104960 - 104960

Published: May 1, 2025

Language: Английский

Citations

0
Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy DOI Creative Commons
Yan Yang, Sijia Li, Kenneth K.W. To

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)

Published: May 16, 2025

Despite the significant advances in development of immune checkpoint inhibitors (ICI), primary and acquired ICI resistance remains impediment to effective cancer immunotherapy. Residing tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a pivotal role progression by regulating diverse signaling pathways. Notably, accumulating evidence has confirmed that TAMs interplay with various cellular components within TME directly or indirectly maintain dynamic balance M1/M2 ratio shape an immunosuppressive TME, consequently conferring evasion immunotherapy tolerance. Detailed investigation communication network around could provide potential molecular targets optimize therapies. In this review, we systematically summarize latest understanding origin functional plasticity TAMs, focus on key pathways driving macrophage polarization stimuli regulate process. Moreover, elaborate intricate between other constituents is initiation, evasion, exploring novel for We further discuss current challenges future research directions, emphasizing need decode TAM-TME interactions translate preclinical findings into clinical breakthroughs. conclusion, while TAM-targeted therapies hold promise enhancing outcomes, addressing challenges-such as TAM heterogeneity, context-dependent plasticity, therapeutic resistance-remains critical achieving optimal efficacy.

Language: Английский

Citations

0
Immunosuppressive tumor microenvironment in pancreatic cancer: mechanisms and therapeutic targets DOI Creative Commons

Da Pan,

Xinyue Li,

Xiao Qiao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030. Conventional interventions including surgery, radiotherapy, and chemotherapy provide only modest survival benefits, underscoring an urgent need for more effective therapies. Although immunotherapy has revolutionized management several solid tumors, its clinical benefit in pancreatic so far been disappointing. Mounting evidence indicates that a highly immunosuppressive tumor microenvironment (TME), dominated tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), regulatory T (Tregs), drives immune evasion, progression, metastasis, chemoresistance through complex cytokine chemokine networks. This review summarizes current knowledge these mechanisms provides emerging strategies aimed at re-educating or depleting cellular constituents enhance efficacy cancer.

Language: Английский

Citations

0
Unraveling the advances of non-coding RNAs on the tumor microenvironment: innovative strategies for cancer therapies DOI Creative Commons
Di Mu, Bing Han, Yi Luo

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: June 2, 2025

Non-coding RNAs (ncRNAs) are crucial molecules that do not encode proteins but play roles in regulating various biological processes. Recent research highlights ncRNAs only control gene expression within cells also facilitate intercellular communication via exosomes and other carriers. This function is vital the tumor microenvironment (TME). Our review covers structure functions of different ncRNAs, such as microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs). We examine how these influence initiation progression. Additionally, we explore their role promoting growth or immune evasion by modulating TME. The potential using therapeutic targets biomarkers for clinical use discussed. As our understanding grows, development new therapies based on anticipated to offer improved treatment options cancer patients.

Language: Английский

Citations

0