The Interrelationship between HIV Infection and COVID-19: A Review of the Literature DOI
Yiyu Wang, Yu Lai

Current HIV Research, Journal Year: 2023, Volume and Issue: 22(1), P. 6 - 15

Published: Dec. 28, 2023

Abstract: The Corona Virus Disease 2019 (COVID-19) pandemic resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to significant morbidity and mortality in patients put a strain on healthcare systems worldwide. clinical characteristics results of COVID-19 immunosuppressed patients, such as people living with human immunodeficiency virus (PLWH), considered at higher risk disease, are not well-characterized. Accumulated evidence indicates that (HIV) can interact various ways. This review explored similarities differences virology between SARS-CoV-2 HIV, effect vaccine PLWH, impact PLWH care prevention, influence HIV-related factors COVID-19. Discovering potential link HIV may provide novel way avoid coinfection advance future research.

Language: Английский

Effects of telehealth-assisted interventions among people living with HIV/AIDS: A systematic review and meta-analysis of randomized controlled studies DOI
Ita Daryanti Saragih, Santo Imanuel Tonapa, Charles Peter Osingada

et al.

Journal of Telemedicine and Telecare, Journal Year: 2021, Volume and Issue: 30(3), P. 438 - 450

Published: Dec. 30, 2021

Taking antiretroviral therapy (ART) is a daily necessity for people living with HIV but these individuals experience multiple barriers and challenges to medication adherence. Interventions support adherence have yielded effects in the expected direction, extent which telehealth or virtually delivered interventions promote are effective among HIV/AIDS remains unknown. We aimed address this knowledge gap inform future research practice that promotes well-being of HIV/AIDs through addressing use.

Language: Английский

Citations

18
IgA nephropathy and spinal epidural abscess after COVID-19 infection: a case report DOI
Burak Göre, Ezgi Çoşkun Yenigün, Şimal Köksal Cevher

et al.

Future Virology, Journal Year: 2022, Volume and Issue: 17(9), P. 611 - 615

Published: June 28, 2022

A 56-year-old male admitted to the hospital for generalized weakness and fever. He was treated in 10 days due COVID-19. did not receive any immunosuppressive therapy during admission. One day after his discharge he experienced back pain received analgesic days. About one month later severe gross hematuria. with acute kidney injury new-onset lower extremity muscle weakness. His renal biopsy revealed IgA nephropathy thoracic/cervical/lumbar-spine imaging showed an epidural abscess. This is a unique case report of patient developing abscess together as serious complication COVID-19 infection.

Language: Английский

Citations

11
Development of Acute Transverse Myelitis following COVID-19 Infection: A Review on the Potential Pathways DOI Open Access
Majid Reza Farrokhi, Farideh Iravanpour,

Negar Nejabat

et al.

European Neurology, Journal Year: 2023, Volume and Issue: 86(3), P. 209 - 216

Published: Jan. 1, 2023

Background: Acute transverse myelitis (ATM) is a rare neurological disorder in adults characterized by localized inflammation of gray and white matter one or more contiguous spinal cord segments the absence compressive injury. Several reports have connected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to pathophysiology ATM. Summary: Direct invasion cord, cytokine storm, an autoimmune response are possible pathways which SARS-CoV-2 virus can affect lead facilitated presence angiotensin-converting enzyme (ACE2) receptors on membranes neurons. Cytokine storm could be derived from elevated levels several immunological factors following involvement with disease 2019 (COVID-19). Finally, responses cause post-infectious ATM through hypothesized processes, including molecular mimicry, epitope spreading, bystander activation, polyclonal B-cell activation. Key Messages: COVID-19-induced mostly longitudinally-extensive (LEATM), damaged, results worse sequel compared short-segment Therefore, it suggested that COVID-19 patients, particularly cases, followed up for probable incidence ATM, even long after recovery elimination host, because early diagnosis effective therapy may stop spread adjacent segments.

Language: Английский

Citations

6
Investigation of the effects of N-Acetylglucosamine on the stability of the spike protein in SARS-CoV-2 by molecular dynamics simulations DOI Open Access
E. Deniz Tekin

Computational and Theoretical Chemistry, Journal Year: 2023, Volume and Issue: 1222, P. 114049 - 114049

Published: Feb. 1, 2023

Language: Английский

Citations

4
African and Asian Medicinal Plants as a Repository for Prospective Antiviral Metabolites Against HIV-1 and SARS CoV-2: A Mini Review DOI Creative Commons
Godwin Anywar, Muhammad Akram,

Muhammad Amjad Chishti

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 25, 2021

The worldwide burden of viral infections has triggered a resurgence in the search for new and more efficient antiviral drugs. Scientists are also repurposing existing natural compounds such as antimalarial drug artemisinin from

Language: Английский

Citations

10
SARS-CoV-2 and HIV-1: So Different yet so Alike. Immune Response at the Cellular and Molecular Level DOI Creative Commons

Catherine Demoliou,

Christos Papaneophytou, Vicky Nicolaidou

et al.

International Journal of Medical Sciences, Journal Year: 2022, Volume and Issue: 19(12), P. 1787 - 1795

Published: Jan. 1, 2022

In the past half century, humanity has experienced two devastating pandemics; HIV-1 pandemic and recent caused by SARS-CoV-2.Both emerged as zoonotic pathogens.Interestingly, SARS-CoV-2 rapidly migrated all over world in less than years, much did almost 40 years ago.Despite these RNA viruses being different their mode of transmission well symptoms they generate, evidence suggests that cause similar immune responses.In this mini review, we compare molecular basis for CD4 + T cell lymphopenia other effects on system induced infections.We considered features host response are shared with could account observed COVID-19.The information provided herein, may cast virus-induced cytokine storm associated acute infection pathogenesis a light further research responses.It can also provide opportunities identification novel therapeutic targets COVID-19.Furthermore, some basic to enable comparative framework considering overlapping sets responses SARS-CoV-2.

Language: Английский

Citations

7
The Impact of COVID-19 on People Living with HIV-1 and HIV-1-Associated Neurological Complications DOI Creative Commons
Debashis Dutta,

Jianuo Liu,

Huangui Xiong

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(5), P. 1117 - 1117

Published: May 5, 2023

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of coronavirus disease 2019 (COVID-19) pandemic, a fatal illness. associated risk factors for COVID-19 are old age and medical comorbidities. In current combined antiretroviral therapy (cART) era, significant portion people living with HIV-1 (PLWH) controlled viremia older comorbidities, making these vulnerable to SARS-CoV-2 infection COVID-19-associated outcomes. Additionally, neurotropic causes neurological complications, resulting in health burden an adverse impact on PLWH exacerbating HIV-1-associated neurocognitive disorder (HAND). severity neuroinflammation, development HAND preexisting poorly explored. present review, we compiled knowledge differences similarities between HIV-1, conditions SARS-CoV-2/COVID-19 HIV-1/AIDS syndemic their central nervous system (CNS). Risk manifestations, inflammatory mechanisms leading syndrome, HAND, its influence also discussed. Finally, have reviewed challenges world population, particular emphasis PLWH.

Language: Английский

Citations

4
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication DOI
S. Das, Sreyashi Nath,

Shahjahan

et al.

DARU Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 32(2), P. 801 - 823

Published: July 19, 2024

Language: Английский

Citations

1
“HIV has taught us that you can survive anything”: findings from auto-ethnographic video diaries exploring resilience among people living with HIV during the Covid pandemic in five countries DOI Creative Commons
Marija Pantelic,

Zara Coombes,

Pax Barnard

et al.

AIDS Care, Journal Year: 2023, Volume and Issue: 36(3), P. 351 - 357

Published: May 1, 2023

This study aimed to elucidate the intrinsic and extrinsic resilience resources among people living with HIV (PLWH) during Covid pandemic. Autoethnographic video diaries from 29 PLWH Argentina, UK, Philippines, Zimbabwe, Trinidad Tobago were included. Data thematically analysed validated community partners a was co-produced. displayed readiness adopt healthy behaviours engage in optimistic constructive thinking about future. Hobbies daily activities, supportive relationships peers HIV, family friends, opportunities mobilise contribute their communities meaningful ways, healthcare providers reliable access antiretroviral treatment helped foster psychological PLWH. The also supported positive physical health outcomes through improved medication adherence.

Language: Английский

Citations

3
Whole genome CRISPR screening strategy to identify genes contributing to SARS‐CoV‐2 spike and VSV‐G mediated entry DOI
Md. Saddam Hossain,

Jason G. Kerkvliet,

Adam D. Hoppe

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(9)

Published: Sept. 1, 2023

Abstract Understanding the cellular host factors that promote and inhibit viral entry is important for identifying countermeasures. CRISPR whole‐genome screens can be used to rapidly discover contribute or impair entry. However, when using live viruses lethality selection, these identify an overwhelming number of genes without specificity stage infection cycle. New screening methods are needed machinery contributing specific steps infection. Here, we developed a screen counter‐screen strategy based on pseudoviral platform allowed identification severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike vesicular stomatitis virus glycoprotein (VSV‐G) mediated Screening SARS‐CoV‐2 VSV‐G same lentiviral pseudovirus entry‐specific relative associated with retro‐transcription, integration, reporter expression from pseudovirus. Second, Cre‐Gag fusion protein packaged into was bypass retro‐transcription integration by directly activating floxed fluorescent upon reduced gene hits increase Our approach correctly identified receptors ACE2 low‐density lipoprotein receptors, respectively, distinguished retroviral envelope‐mediated Moreover, CRE‐Gag fusion/flox increased entry‐associated genes. Validation few demonstrates this distinguishes envelope‐specific affecting expression. Overall, provides new influencing confounding complexity live‐viral which produce long lists all aspects pathogenesis replication.

Language: Английский

Citations

3