A Review of miRNA Regulation in Japanese Encephalitis (JEV) Virus Infection DOI
Maneesh Kumar, Ganesh Chandra Sahoo, Vidya Nand Rabi Das

et al.

Current Pharmaceutical Biotechnology, Journal Year: 2023, Volume and Issue: 25(5), P. 521 - 533

Published: Oct. 15, 2023

Japanese encephalitis (JE) is a mosquito-borne disease that causes neuronal damage and inflammation of microglia, in severe cases, it can be fatal. JE infection resist cellular immune responses survive host cells. virus (JEV) infects macrophages peripheral blood lymphocytes. In addition to regulating biological signaling pathways, microRNAs cells also influence virus-host interactions. Under certain circumstances, viruses change microRNA production. These changes affect the replication spread virus. Host miRNAs contain viral pathogenicity by downregulating antiviral response pathways. Simultaneous profiling miRNA messenger RNA (mRNA) could help us detect pathogenic factors, dual detection possible. This work highlights important involved human infection. this study, we have shown play significant roles JEV We found during infection, miRNA-155, miRNA-29b, miRNA-15b, miRNA-146a, miRNA-125b-5p, miRNA-30la, miRNA-19b-3p, miRNA-124, cause upregulation genes whereas miRNA-432, miRNA-370, miRNA- 33a-5p, miRNA-466d-3p are responsible for downregulation respectively. Further, these inflammatory effects. Although several other critical life cycle yet unknown, there currently no evidence role persistence.

Language: Английский

Systematic review of overlapping microRNA patterns in COVID-19 and idiopathic pulmonary fibrosis DOI Creative Commons
Julien Guiot, Monique Henket, Claire Remacle

et al.

Respiratory Research, Journal Year: 2023, Volume and Issue: 24(1)

Published: April 15, 2023

Abstract Background Pulmonary fibrosis is an emerging complication of SARS-CoV-2 infection. In this study, we speculate that patients with COVID-19 and idiopathic pulmonary (IPF) may share aberrant expressed microRNAs (miRNAs) associated to the progression lung fibrosis. Objective To identify miRNAs presenting similar alteration in IPF, describe their impact on fibrogenesis. Methods A systematic review literature published between 2010 January 2022 (PROSPERO, CRD42022341016) was conducted using key words (COVID-19 OR SARS-CoV-2) AND (microRNA miRNA) or (idiopathic IPF) Title/Abstract. Results Of 1988 references considered, 70 original articles were appropriate for data extraction: 27 studies focused COVID-19, 43 IPF. 34 overlapping 7 upregulation (miR-19a-3p, miR-200c-3p, miR-21-5p, miR-145-5p, miR-199a-5p, miR-23b miR-424) 9 a downregulation (miR-17-5p, miR-20a-5p, miR-92a-3p, miR-141-3p, miR-16-5p, miR-142-5p, miR-486-5p, miR-708-3p miR-150-5p). Conclusion Several reported elevated levels profibrotic context. addition, balance antifibrotic responsible modulation fibrotic processes impaired COVID-19. This evidence suggests deregulation fibrotic-related participates development lesions post-COVID-19 patients.

Language: Английский

Citations

26
miRNAs as a Potential Biomarker in the COVID-19 Infection and Complications Course, Severity, and Outcome DOI Creative Commons
Milena Janković, Dejan Nikolić, Ivana Novaković

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1091 - 1091

Published: March 14, 2023

During the last three years, since emergence of COVID-19 pandemic, a significant number scientific publications have focused on resolving susceptibility to infection, as well course disease and potential long-term complications. is widely considered multisystem variety socioeconomic, medical, genetic/epigenetic factors may contribute severity outcome. Furthermore, SARS-COV-2 infection trigger pathological processes accelerate underlying conditions clinical entities. The development specific sensitive biomarkers that are easy obtain will allow for patient stratification, prevention, prognosis, more individualized treatments COVID-19. miRNAs proposed promising different aspects (susceptibility, severity, complication course, outcome, therapeutic possibilities). This review summarizes most relevant findings concerning miRNA involvement in pathology. Additionally, role wide range complications due accompanied and/or health discussed. importance understanding functional relationships between conditions, such pregnancy, obesity, or neurological diseases, with also highlighted.

Language: Английский

Citations

14
Emerging anti-spike monoclonal antibodies against SARS-CoV-2 DOI
Eloy E. Ordaya, Raymund R. Razonable

Expert Opinion on Biological Therapy, Journal Year: 2024, Volume and Issue: 24(3), P. 191 - 201

Published: March 3, 2024

Introduction Anti-spike monoclonal antibodies (mAbs) were previously authorized for the prevention and treatment of COVID-19 in immunocompromised patients. However, they are no longer U.S. due to their lack neutralizing activity against current circulating SARS-CoV-2 Omicron variants.

Language: Английский

Citations

5
Bioaccessibility of phenolic compounds from Brazilian grape juices using a digestion model with intestinal barrier passage DOI
Maria da Conceição Prudêncio Dutra, Ana Beatriz Martins da Silva, Ederlan de Souza Ferreira

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 52, P. 102501 - 102501

Published: Feb. 25, 2023

Language: Английский

Citations

11
SARS-CoV-2 Transplacental Transmission: A Rare Occurrence? An Overview of the Protective Role of the Placenta DOI Open Access
Yin Ping Wong, Geok Chin Tan, T. Yee Khong

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4550 - 4550

Published: Feb. 25, 2023

The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel severe acute respiratory syndrome 2 (SARS-CoV-2), has resulted in a global public health crisis, causing substantial concern especially to pregnant population. Pregnant women infected with SARS-CoV-2 are at greater risk devastating pregnancy complications such as premature delivery and stillbirth. Irrespective emerging reported cases neonatal COVID-19, reassuringly, confirmatory evidence vertical transmission is still lacking. protective role placenta limiting utero spread virus developing fetus intriguing. short- long-term impact maternal COVID-19 infection newborn remains an unresolved question. In this review, we explore recent transmission, cell-entry pathways, placental responses towards infection, its potential effects on offspring. We further discuss how serves defensive front against exerting various cellular molecular defense pathways. A better understanding barrier, immune defense, modulation strategies involved restricting transplacental may provide valuable insights for future development antiviral immunomodulatory therapies improve outcomes.

Language: Английский

Citations

11
SARS-CoV-2 Invasion and Pathological Links to Prion Disease DOI Creative Commons
Walter J. Lukiw,

Vivian Jaber,

Aileen I. Pogue

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1253 - 1253

Published: Sept. 7, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 disease, is a highly infectious and transmissible viral pathogen that continues to impact human health globally. Nearly ~600 million people have been infected with SARS-CoV-2, about half exhibit some degree continuing complication, generically referred as long COVID. Lingering often serious neurological problems for patients in post-COVID-19 recovery period include brain fog, behavioral changes, confusion, delirium, deficits intellect, cognition memory issues, loss balance coordination, vision, visual processing hallucinations, encephalopathy, encephalitis, neurovascular or cerebrovascular insufficiency, and/or impaired consciousness. Depending upon patient’s age at onset other factors, up ~35% all elderly develop mild-to-severe encephalopathy due complications arising from SARS-CoV-2-induced cytokine storm surge cytokine-mediated pro-inflammatory immune signaling. In fact, this syndrome: (i) appears predispose aged development complications, especially those who experienced more grade infection; (ii) lies along interactive pathological pathways involving SARS-CoV-2 infection promotes parallel intensification progressive lethal conditions, (iii) strongly associated symptomology, onset, prion disease (PrD) insidious incurable syndromes. This commentary paper will evaluate recent peer-reviewed studies intriguing area SARS-CoV-2-associated neuropathology assess how chronic, viral-mediated changes CNS contribute cognitive decline PrD progressive, age-related neurodegenerative disorders.

Language: Английский

Citations

16
Differentially‐regulated miRNAs in COVID‐19: A systematic review DOI Creative Commons
Waqar Ahmad, Bushra Gull, Jasmin Baby

et al.

Reviews in Medical Virology, Journal Year: 2023, Volume and Issue: 33(4)

Published: May 5, 2023

Abstract Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is responsible for coronavirus disease of 2019 (COVID‐19) that infected more than 760 million people worldwide with over 6.8 deaths to date. COVID‐19 one the most challenging diseases our times due nature its spread, effect on multiple organs, and an inability predict prognosis, ranging from being completely asymptomatic death. Upon infection, SARS‐CoV‐2 alters host immune response by changing host‐transcriptional machinery. MicroRNAs (miRNAs) are regarded as post‐transcriptional regulators gene expression can be perturbed invading viruses. Several in vitro vivo studies have reported such dysregulation miRNA upon infection. Some this could occur anti‐viral viral Viruses themselves counteract mounting their own pro‐viral facilitates virus aspect which may cause pathogenesis. Thus, miRNAs serve possible biomarkers people. In current review, we summarised analysed existing data about patients determine concordance between studies, identified those potential during progression, death, even other co‐morbidities. Having vital not only predicting but also development novel miRNA‐based anti‐virals therapeutics become invaluable case emergence new variants pandemic future.

Language: Английский

Citations

9
The relationship between microRNAs and COVID-19 complications DOI Creative Commons

Abdollah Kebriaei,

Reza Besharati,

Hasan Namdar Ahmad Abad

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 10, P. 16 - 24

Published: Aug. 23, 2024

Language: Английский

Citations

2
Recent research on the bioactivity of polyphenols derived from edible fungi and their potential in chronic disease prevention DOI Creative Commons

Wenbin Yu,

Yufei Zhang, Yi Lu

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106627 - 106627

Published: Dec. 12, 2024

Language: Английский

Citations

2
In silico analysis of SARS-CoV-2 genomes: Insights from SARS encoded non-coding RNAs DOI Creative Commons

Neha Periwal,

Urvashi Bhardwaj,

Sankritya Sarma

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: Nov. 28, 2022

The recent pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 has resulted in enormous deaths around the world. Clues from genomic sequences of parent and their mutants can be obtained to understand evolving pathogenesis this virus. Apart viral proteins, virus-encoded microRNAs (miRNAs) have been shown play a vital role regulating pathogenesis. Thus we sought investigate miRNAs encoded SARS-CoV-2, its mutants, host. Here, present results using dual approach i.e (i) identifying host-encoded that might regulate (ii) viral-encoded host cell signaling pathways aid Analysis utilizing first identification ten could target SARS, mutants. Interestingly our analysis revealed there is significantly higher number SARS-CoV-2 genome as compared SARS reference genome. Results second set which pathways. Our further identified similar “GA” rich motif mutant genomes was lung during severe infections. In summary, human coronaviruses describe non-coding RNA were SARS-induced pathology mice.

Language: Английский

Citations

8