A Review of miRNA Regulation in Japanese Encephalitis (JEV) Virus Infection DOI
Maneesh Kumar, Ganesh Chandra Sahoo, Vidya Nand Rabi Das

et al.

Current Pharmaceutical Biotechnology, Journal Year: 2023, Volume and Issue: 25(5), P. 521 - 533

Published: Oct. 15, 2023

Japanese encephalitis (JE) is a mosquito-borne disease that causes neuronal damage and inflammation of microglia, in severe cases, it can be fatal. JE infection resist cellular immune responses survive host cells. virus (JEV) infects macrophages peripheral blood lymphocytes. In addition to regulating biological signaling pathways, microRNAs cells also influence virus-host interactions. Under certain circumstances, viruses change microRNA production. These changes affect the replication spread virus. Host miRNAs contain viral pathogenicity by downregulating antiviral response pathways. Simultaneous profiling miRNA messenger RNA (mRNA) could help us detect pathogenic factors, dual detection possible. This work highlights important involved human infection. this study, we have shown play significant roles JEV We found during infection, miRNA-155, miRNA-29b, miRNA-15b, miRNA-146a, miRNA-125b-5p, miRNA-30la, miRNA-19b-3p, miRNA-124, cause upregulation genes whereas miRNA-432, miRNA-370, miRNA- 33a-5p, miRNA-466d-3p are responsible for downregulation respectively. Further, these inflammatory effects. Although several other critical life cycle yet unknown, there currently no evidence role persistence.

Language: Английский

Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19 DOI Creative Commons
Shukur Wasman Smail,

Sarah Mousa Hirmiz,

Akhter Ahmed Ahmed

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 7, 2024

The pandemic of coronavirus disease-19 (COVID-19), provoked by the appearance a novel named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), required worldwide healthcare emergency. This has elicited an immediate need for accelerated research into its mechanisms disease, criteria diagnosis, methods forecasting outcomes, and treatment approaches. microRNAs (miRNAs), are diminutive RNA molecules, that non-coding participate in gene expression regulation post-transcriptionally, having important participation regulating immune processes. miRNAs have granted substantial interest their impact on viral replication, cell proliferation, modulation how host’s system responds. narrative review delves host miRNAs’ multifaceted roles within COVID-19 context, highlighting involvement disease progression, diagnostics, prognostics aspects, given stability biological fluids varied profiles when responding to infection. Additionally, we discuss complicated interactions between SARS-CoV-2 cellular machinery facilitated revealing dysregulation miRNA advances evasion, inflammatory responses. Furthermore, it investigates potential as therapeutic agents, whether synthetic or naturally occurring, which could be harnessed either mitigate harmful inflammation enhance antiviral However, searching more deeply is needed clarify involved pathogenesis COVID-19, diagnosis processes, prognostic assessments, approaches patients.

Language: Английский

Citations

1
MicroRNA-195-5p mediates arsenic-induced cytotoxicity in human lung epithelial cells: Beneficial role of plant-derived tannic acid DOI

Sehal Mishra,

Neetu Kalra, Mahendran Botlagunta

et al.

Toxicology and Applied Pharmacology, Journal Year: 2023, Volume and Issue: 482, P. 116775 - 116775

Published: Nov. 30, 2023

Language: Английский

Citations

3
COVID-19 Vaccination in Pregnancy: Pilot Study for Maternal and Neonatal MicroRNA Profiles DOI Creative Commons
Wei‐Chun Chen,

Shu-Yu Hu,

Ching‐Fen Shen

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(12), P. 1814 - 1814

Published: Dec. 4, 2023

This pilot study explores alterations in miRNA profiles among pregnant women and their neonates upon receiving different doses of COVID-19 vaccines. Blood samples, including maternal blood (MB) neonatal cord (CB), collected from five were scrutinized using the PanelChip Analysis System, identifying nine distinct miRNAs, miR-451a miR-1972, which exhibited significant downregulation with two vaccine both MB CB. When compared vaccinated four doses, miR-486-5p, miR-451a, miR-1972 two-dose group also showed notable downregulation. Evaluating recipients three miR-423-5p expression significantly reduced Further comparative analysis highlighted a decline miR-223-3p increasing while miR15a-5p, miR-16-5p, an upward trend. Notably, levels varied across associated pathways such as "PI3K-Akt", "neurotrophin signaling", "cortisol synthesis", suggesting profound influence vaccination on diverse molecular mechanisms. Our research has uncovered that escalating dosages impact profiles, may be immunological response mechanisms mother fetus, thus indicating substantial various processes.

Language: Английский

Citations

2
Glycated hemoglobin level dynamics in COVID-19 survivors: 12 months follow-up study after discharge from hospital DOI Creative Commons
М. В. Шестакова, Ирина Владимировна Кононенко, З. А. Калмыкова

et al.

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(11), P. e0275381 - e0275381

Published: Nov. 9, 2022

Introduction One of the stages reproduction SARS-CoV-2 is S-protein glycosylation to facilitate penetration into target cells. It has been suggested that able enter erythrocytes, interact with heme and porphyrin, which could influence HbA1c levels. Assessment levels in individuals acute COVID-19 after recovery may show clinical relevance this hypothesis. Aim To assess patients phase early (6–8 weeks) late (52±2 periods recovery. Materials methods We conducted a multicenter prospective study, included hospitalized Endocrinology Research Centre City Clinical Hospital № 52" diagnosed COVID-19, virus identified/ not identified. Patients were divided three groups according baseline level presence or absence previous history diabetes mellitus (DM): ≤ 6.0%, > 6.0% DM. examined during Oral glucose tolerance test was performed group initial clarify diagnosis. Results 194 study. During follow-up, 52 6–8 week period: 7 34 11—with previously Carbohydrate metabolism assessment later 78 patients: 33 36 9 established diabetes. median 5.7% [5.3;5.8], HbA1c>6.0% -6.4% [6.2; 6.6], DM—7.7% [7.2; 8.9]. Statistically significant decrease over time weeks extracts obtained both without DM (Wilcoxon test, p<0.05). After 52±2 we observed all (Fridman p<0.05): 5.5[5.3;5.7], - 6.1[6.15;6.54], DM—7.8 [5.83; 8.08]. Development recorded 7.24% DM, 16.6% total number dynamics 6.0%. Conclusion elevation be false due effect on hemoglobin kinetics and/or detection surface virion highly glycosylated S-proteins by high performance liquid chromatography determinations. Upon active disease concomitant hyperglycemia re-determine recommended.

Language: Английский

Citations

4
In silico investigation of potential COVID-19-associated microRNA signatures DOI Open Access
Seyedehsadaf Asfa,

Didem Ökmen,

Athanasia Pavlopoulou

et al.

Çukurova medical journal (Online)/Çukurova medical journal, Journal Year: 2024, Volume and Issue: 49(1), P. 170 - 180

Published: March 29, 2024

Purpose: The global pandemic COVID-19, caused by the coronavirus SARS-CoV-2, is persistent despite increasing vaccination rates, with new cases being reported per week. MicroRNAs, that is, non-coding RNA species regulate gene expression at post-transcriptional level, play a pivotal role in SARS-CoV-2 life cycle, pathophysiology and host’s anticoronaviral responses. objective of this study was silico discovery functionally associated miRNAs likely co-regulate COVID-19-related genes Materials Methods: In present study, an integrative bioinformatics approach employed, including database searching, set enrichment analysis, network-based microRNA target prediction methods, towards epigenetic determinants COVID-19. Results: An intricate microRNA-target network constructed, 8 highly interacting microRNAs, potentially co-target key genes, detected. These their corresponding are involved response to infection. Conclusion: could constitute signature for COVID-19 diagnosis.

Language: Английский

Citations

0
Polyphenols in Control of COVID ‐19 DOI

Elyor Berdimurodov,

Khasan Berdimuradov,

Ashish Kumar

et al.

Published: April 2, 2024

Language: Английский

Citations

0
MicroRNA-374b regulates SARS-CoV-2 viral protein mediated endothelial to mesenchymal transition by targeting c-FLIP DOI Open Access

Grace R. Raji,

Aswini Poyyakkara, Vishnu Ramachandran

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Abstract The pathophysiological consequences of COVID-19 disease are still unclear, however, endothelial cell (EC) dysfunction has been observed to play a key role in progression and severity. Many reports suggests that SARS-CoV-2 mediated is the result intracellular signaling initiated by binding spike protein ACE2, which can modify phenotype. Recent mesenchymal transition (Endo MT) as process heavily involved lung fibrosis COVID 19 patients. EndoMT many chronic fibrotic diseases appears be regulated complex molecular mechanisms different pathways, particular microRNAs (miRNAs), constitute crucial mediator EndoMT. MicroRNAs small endogenous RNA molecules regulate several physiological processes including homeostasis, vascular diseases, perturbed infecting viruses. Based on these facts, this study was designed decipher miR-374b, found significantly downregulated upon profiling viral stimulated cells. Gene cells revealed c-FLIP (CFLAR) among most upregulated gene. In silico target prediction analysis using targetscan major miR-374b. Further it identified miR-374b reverse mRNA levels under conditions overexpression. Since involve, circumstances, loss tone due cells, we next checked if events downstream pathway. mechanistic studies involving identification expression pattern markers presence or absence provide evidence for important regulating SARS CoV-2 pathway may highlight possible new therapeutic approaches targeted at damaged endothelium.

Language: Английский

Citations

0
MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation DOI Creative Commons

Hajer A Al Saihati,

Arigue A. Dessouky,

Rabab F. Salim

et al.

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 20, 2024

Language: Английский

Citations

0
MicroRNAs in Viral Infection DOI
Shima Poorghobadi, Maryam Ghanbari Viki, Kazem Baesi

et al.

Epigenetics and human health, Journal Year: 2024, Volume and Issue: unknown, P. 319 - 335

Published: Jan. 1, 2024

Language: Английский

Citations

0
Changes in miRNA Pattern Expression Associated With COVID-19 Severity DOI Open Access
Paola Berenice Zárate-Segura, Macario Martínez–Castillo,

AARÓN PARIS GARDUÑO-GUTIÉRREZ

et al.

In Vivo, Journal Year: 2024, Volume and Issue: 39(1), P. 482 - 490

Published: Dec. 31, 2024

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection, manifests a wide range of clinical symptoms ranging from mild to moderate and severe. Host-related factors influence the course infection; for instance, expression host microRNAs (miRNAs) could progression complications COVID-19. This study aimed determine pattern endogenous miRNAs in 80 severe COVID-19 patients compared group healthy individuals.

Language: Английский

Citations

0