A Review of miRNA Regulation in Japanese Encephalitis (JEV) Virus Infection DOI
Maneesh Kumar, Ganesh Chandra Sahoo, Vidya Nand Rabi Das

et al.

Current Pharmaceutical Biotechnology, Journal Year: 2023, Volume and Issue: 25(5), P. 521 - 533

Published: Oct. 15, 2023

Japanese encephalitis (JE) is a mosquito-borne disease that causes neuronal damage and inflammation of microglia, in severe cases, it can be fatal. JE infection resist cellular immune responses survive host cells. virus (JEV) infects macrophages peripheral blood lymphocytes. In addition to regulating biological signaling pathways, microRNAs cells also influence virus-host interactions. Under certain circumstances, viruses change microRNA production. These changes affect the replication spread virus. Host miRNAs contain viral pathogenicity by downregulating antiviral response pathways. Simultaneous profiling miRNA messenger RNA (mRNA) could help us detect pathogenic factors, dual detection possible. This work highlights important involved human infection. this study, we have shown play significant roles JEV We found during infection, miRNA-155, miRNA-29b, miRNA-15b, miRNA-146a, miRNA-125b-5p, miRNA-30la, miRNA-19b-3p, miRNA-124, cause upregulation genes whereas miRNA-432, miRNA-370, miRNA- 33a-5p, miRNA-466d-3p are responsible for downregulation respectively. Further, these inflammatory effects. Although several other critical life cycle yet unknown, there currently no evidence role persistence.

Language: Английский

Assessing the Expression Levels of miR-1307-3p and miR-3613-5p in COVID-19 Patients DOI Open Access
Rahil Ghanbarnasab Behbahani, Mojtaba Rasti, Nasrin Rastegarvand

et al.

Archives of Clinical Infectious Diseases, Journal Year: 2024, Volume and Issue: 20(2)

Published: Dec. 28, 2024

Background: MicroRNAs (miRNAs) regulate the immune response to infectious diseases. They exhibit alterations during early stages of disease development, even before pathogen is detectable. Objectives: The objective this study was analyze expression levels miR-1307-3p and miR-3613-5p at onset COVID-19, aiming identify miRNAs that could function as predictive biomarkers. Methods: This case-control analyzed COVID-19 Plasma from 26 patients hospitalized in ICU ward were sequenced compared a healthy control group individuals. Additionally, plasma biomarkers associated with system evaluated. Total RNA extracted using an RNX solution subjected cDNA synthesis specific loop sequence for each miRNA. samples subsequently relative real-time PCR. Results: RT-qPCR analysis revealed significant reduction detection rate (P < 0.0001) patient group. Conversely, no differences observed between groups. Conclusions: shows potential biomarker diagnosis COVID-19.

Language: Английский

Citations

0
A Review of miRNA Regulation in Japanese Encephalitis (JEV) Virus Infection DOI
Maneesh Kumar, Ganesh Chandra Sahoo, Vidya Nand Rabi Das

et al.

Current Pharmaceutical Biotechnology, Journal Year: 2023, Volume and Issue: 25(5), P. 521 - 533

Published: Oct. 15, 2023

Japanese encephalitis (JE) is a mosquito-borne disease that causes neuronal damage and inflammation of microglia, in severe cases, it can be fatal. JE infection resist cellular immune responses survive host cells. virus (JEV) infects macrophages peripheral blood lymphocytes. In addition to regulating biological signaling pathways, microRNAs cells also influence virus-host interactions. Under certain circumstances, viruses change microRNA production. These changes affect the replication spread virus. Host miRNAs contain viral pathogenicity by downregulating antiviral response pathways. Simultaneous profiling miRNA messenger RNA (mRNA) could help us detect pathogenic factors, dual detection possible. This work highlights important involved human infection. this study, we have shown play significant roles JEV We found during infection, miRNA-155, miRNA-29b, miRNA-15b, miRNA-146a, miRNA-125b-5p, miRNA-30la, miRNA-19b-3p, miRNA-124, cause upregulation genes whereas miRNA-432, miRNA-370, miRNA- 33a-5p, miRNA-466d-3p are responsible for downregulation respectively. Further, these inflammatory effects. Although several other critical life cycle yet unknown, there currently no evidence role persistence.

Language: Английский

Citations

1