Advances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase DOI Creative Commons
Bin Xiao, Shunhong Wu, Yan Tian

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 41(1)

Published: Dec. 27, 2024

N-acetyltransferase 10 (NAT10) is a member of the Gcn5-related (GNAT) family and it plays crucial role in various cellular processes, such as regulation cell mitosis, post-DNA damage response, autophagy apoptosis regulation, ribosome biogenesis, RNA modification, other related pathways through its intrinsic protein acetyltransferase activities. Moreover, NAT10 closely associated with pathogenesis tumors, Hutchinson-Gilford progeria syndrome (HGPS), systemic lupus erythematosus, pulmonary fibrosis, depression host–pathogen interactions. In recent years, mRNA acetylation has emerged prominent focus research due to pivotal regulating stability translation. stands out sole identified modification enzyme responsible for acetylation. There remains some ambiguity regarding similarities differences NAT10's actions on substrates. While involves both cases, which molecular mechanism epigenetic there are significant disparities catalytic mechanisms, regulatory pathways, biological processes involved. Therefore, this review aims offer comprehensive overview acetyltransferase, covering basic features, functions, roles diseases.

Language: Английский

Exploring the role of NAT10 in regulating EMT and JAK2/STAT3 pathway activation in cervical cancer progression DOI Creative Commons
Ya‐Wen Chen,

Gaimei Xue,

Yong-hua Hu

et al.

Asian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0
Advances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase DOI Creative Commons
Bin Xiao, Shunhong Wu, Yan Tian

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 41(1)

Published: Dec. 27, 2024

N-acetyltransferase 10 (NAT10) is a member of the Gcn5-related (GNAT) family and it plays crucial role in various cellular processes, such as regulation cell mitosis, post-DNA damage response, autophagy apoptosis regulation, ribosome biogenesis, RNA modification, other related pathways through its intrinsic protein acetyltransferase activities. Moreover, NAT10 closely associated with pathogenesis tumors, Hutchinson-Gilford progeria syndrome (HGPS), systemic lupus erythematosus, pulmonary fibrosis, depression host–pathogen interactions. In recent years, mRNA acetylation has emerged prominent focus research due to pivotal regulating stability translation. stands out sole identified modification enzyme responsible for acetylation. There remains some ambiguity regarding similarities differences NAT10's actions on substrates. While involves both cases, which molecular mechanism epigenetic there are significant disparities catalytic mechanisms, regulatory pathways, biological processes involved. Therefore, this review aims offer comprehensive overview acetyltransferase, covering basic features, functions, roles diseases.

Language: Английский

Citations

0