LINC00534 promotes breast cancer progression by targeting the miR-139-5p/HMGB2 axis

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 2, 2025

Breast cancer is the most prevalent malignancy among women, it crucial to identify sensitive biomarkers for prognosis and treatment of breast patients. Emerging research has demonstrated involvement long noncoding RNAs (lncRNAs) in advancement cancer. LINC00534 recently emerged as a potential regulator multiple malignancies, yet its clinical significance molecular mechanisms remain poorly characterized. The purpose this study was explore function miR-139-5p progression, well that underpin actions. Tumor normal tissues were collected from 80 qRT-PCR performed detect expression tissues. Kaplan-Meier analysis used assess survival differences between groups correlation outcomes. CCK-8 assay evaluate cell proliferation LINC00534's effect on tumor growth. To impact metastasis, transwell migration invasion abilities cells. Moreover, dual-luciferase verify relationship within LINC00534/miR-139-5p/HMGB2 axis. significantly upregulated lines (p < 0.001). Higher correlated with poorer patients, including shorter higher recurrence risk (Log-rank p = 0.014). Furthermore, promoted proliferation, migration, (all 0.001) via interaction miR-139-5p/HMGB2 may serve prognostic marker axis could be therapeutic target

Language: Английский

The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Dec. 1, 2024

Abstract RNA modification has emerged as a crucial area of research in epigenetics, significantly influencing tumor biology by regulating metabolism. N‐acetyltransferase 10 (NAT10)‐mediated N4‐acetylcytidine (ac4C) modification, the sole known acetylation eukaryotic RNA, influences cancer pathogenesis and progression. NAT10 is only writer ac4C catalyzes acetyl transfer on targeted helps to improve stability translational efficiency ac4C‐modified RNA. highly expressed associated with poor prognosis pan‐cancers. Based its molecular mechanism biological functions, central factor tumorigenesis, progression, drug resistance, immune escape. Despite increasing focus ac4C, specific regulatory mechanisms remain elusive. The present review thoroughly analyzes current knowledge NAT10‐mediated cancer, highlighting broad influence gene expression biology. This also summarizes limitations perspectives identify new therapeutic targets advance treatment strategies.

Language: Английский

Exosomal noncoding RNA (ncRNA) in breast cancer pathogenesis and therapy; two sides of the same coin

Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(1), P. 114359 - 114359

Published: Nov. 26, 2024

Language: Английский